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Ultrasound- Guided Sono- Photomechanic Combination Therapy Of Abdominal Aorta Atherothrombosis Accompanied By Simultaneously Plga- Based Encapsulated Tpa Nanoparticles And Pesda Microbubbles Administration
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a hamster model of abdominal aorta atherothrombotic stenosis and the subsequent investigating the feasibility of sono- photomechanic combination thrombolytic therapy accompanied by simultaneously PLGA- based encapsulated tPA nanoparticles and microbubbles administration in this model.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. mehrad Tags: Posters 26 - 29 May, 2019 Source Type: research

B- Mode Ultrasound- Guided Catheter- Based Q-Switched Nd: Yag Laser- Mediated Inertial Cavitation Therapy Of Embolic Artery Accompanied By Simultaneously Streptokinase And Pesda Microbubbles Administration
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. Catheter-based lasers have been extensively studied as an effective method to treat thrombosis. The aim of this study was to generate a rabbit model of femoral artery thromboembolism occlusion and the subsequent investigating the feasibility of Q-switched Nd: YAG laser thrombolytic therapy accompanied by simultaneously intravenous streptokinase and PESDA microbubbles administration in this model.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. mehrad Tags: Posters 26 - 29 May, 2019 Source Type: research

Early Stage Atherosclerosis Regression In The Rabbit Carotid Artery Using 5- Aminolevulinic Acid – Loaded Pesda Microbubbles- Mediated Shock Wave- Photodynamic Combination Therapy
In this study, we developed an experimental shock wave- photodynamic combination therapy protocol, and investigated its effectiveness on macrophage foam cells density reduction.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. Mehrad, A. Najafzadeh, S. Pourhaji aga golestani Tags: Posters 26 - 29 May, 2019 Source Type: research

The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events
Atherosclerosis is an underlying cause of a broad array of cardiovascular diseases characterized by plaques, arterial wall thickening initiated by hyperlipidemia, pro-inflammatory signals, endothelial dysfunction and the influx of inflammatory cells. By still incompletely characterized mechanisms, these plaques can destabilize or erode, leading to thrombosis and blood vessel occlusion and becomes clinically manifest as angina pectoris, myocardial infarction (MI) or stroke.Among the several blood cell types that are involved in the development of atherosclerosis, the role of platelets during the thrombotic occlusion of rupt...
Source: Atherosclerosis - December 22, 2020 Category: Cardiology Authors: Dani ëlle M. Coenen, Alexandra C.A. Heinzmann, Mieke F.A. Karel, Judith M.E.M. Cosemans, Rory R. Koenen Tags: Review article Source Type: research

Active factor XI is associated with the risk of cardiovascular events in stable coronary artery disease patients
Tissue factor (TF) and activated factor XI (FXIa) have been associated with acute coronary syndrome, ischemic stroke and venous thromboembolism. Their predictive value in stable coronary artery disease (CAD) is unclear. We investigated whether active TF and FXIa were associated with clinical outcomes in CAD patients in long-term observation.
Source: Atherosclerosis - February 10, 2022 Category: Cardiology Authors: El żbieta Paszek, Elżbieta Pociask, Michał Ząbczyk, Adam Piórkowski, Saulius Butenas, Jacek Legutko, Anetta Undas Source Type: research

Inertial cavitation-mediated catheter- based Q-switched Nd: YAG laser therapy in combination with extracorporeal electrohydraulic low- level focused shock wave therapy for thrombolysis of embolic artery
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a rabbit model of carotid artery thromboembolic occlusion and the subsequent investigating the feasibility of catheter- based Q-switched Nd: YAG laser therapy accompanied by simultaneously extracorporeal shock wave therapy in this model.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: H. Mehrad Source Type: research

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