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Source: Atherosclerosis
Condition: Thrombosis
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Total 21 results found since Jan 2013.
Inertial cavitation-mediated catheter- based Q-switched Nd: YAG laser therapy in combination with extracorporeal electrohydraulic low- level focused shock wave therapy for thrombolysis of embolic artery
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a rabbit model of carotid artery thromboembolic occlusion and the subsequent investigating the feasibility of catheter- based Q-switched Nd: YAG laser therapy accompanied by simultaneously extracorporeal shock wave therapy in this model.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: H. Mehrad Source Type: research
Active factor XI is associated with the risk of cardiovascular events in stable coronary artery disease patients
Tissue factor (TF) and activated factor XI (FXIa) have been associated with acute coronary syndrome, ischemic stroke and venous thromboembolism. Their predictive value in stable coronary artery disease (CAD) is unclear. We investigated whether active TF and FXIa were associated with clinical outcomes in CAD patients in long-term observation.
Source: Atherosclerosis - February 10, 2022 Category: Cardiology Authors: El żbieta Paszek, Elżbieta Pociask, Michał Ząbczyk, Adam Piórkowski, Saulius Butenas, Jacek Legutko, Anetta Undas Source Type: research
The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events
Atherosclerosis is an underlying cause of a broad array of cardiovascular diseases characterized by plaques, arterial wall thickening initiated by hyperlipidemia, pro-inflammatory signals, endothelial dysfunction and the influx of inflammatory cells. By still incompletely characterized mechanisms, these plaques can destabilize or erode, leading to thrombosis and blood vessel occlusion and becomes clinically manifest as angina pectoris, myocardial infarction (MI) or stroke.Among the several blood cell types that are involved in the development of atherosclerosis, the role of platelets during the thrombotic occlusion of rupt...
Source: Atherosclerosis - December 22, 2020 Category: Cardiology Authors: Dani ëlle M. Coenen, Alexandra C.A. Heinzmann, Mieke F.A. Karel, Judith M.E.M. Cosemans, Rory R. Koenen Tags: Review article Source Type: research
Developing Of A New Animal Artery Model Of Atherothrombotic Stenosis Using Radiofrequency Thermal Balloon Angioplasty- Mediated Endothelial Injury: Monitored By Color Doppler Ultrasonography And Histopathology
Background and Aims: A plaque may rupture with high risk of subsequent thrombus- mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a reproducible experimental hamster abdominal aorta model of atherothrombotic stenosis with morphological similarities to the human disease.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. mehrad Tags: Posters 26 - 29 May, 2019 Source Type: research
Ultrasound- Guided Sono- Photomechanic Combination Therapy Of Abdominal Aorta Atherothrombosis Accompanied By Simultaneously Plga- Based Encapsulated Tpa Nanoparticles And Pesda Microbubbles Administration
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a hamster model of abdominal aorta atherothrombotic stenosis and the subsequent investigating the feasibility of sono- photomechanic combination thrombolytic therapy accompanied by simultaneously PLGA- based encapsulated tPA nanoparticles and microbubbles administration in this model.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. mehrad Tags: Posters 26 - 29 May, 2019 Source Type: research
B- Mode Ultrasound- Guided Catheter- Based Q-Switched Nd: Yag Laser- Mediated Inertial Cavitation Therapy Of Embolic Artery Accompanied By Simultaneously Streptokinase And Pesda Microbubbles Administration
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. Catheter-based lasers have been extensively studied as an effective method to treat thrombosis. The aim of this study was to generate a rabbit model of femoral artery thromboembolism occlusion and the subsequent investigating the feasibility of Q-switched Nd: YAG laser thrombolytic therapy accompanied by simultaneously intravenous streptokinase and PESDA microbubbles administration in this model.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. mehrad Tags: Posters 26 - 29 May, 2019 Source Type: research
Early Stage Atherosclerosis Regression In The Rabbit Carotid Artery Using 5- Aminolevulinic Acid – Loaded Pesda Microbubbles- Mediated Shock Wave- Photodynamic Combination Therapy
In this study, we developed an experimental shock wave- photodynamic combination therapy protocol, and investigated its effectiveness on macrophage foam cells density reduction.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. Mehrad, A. Najafzadeh, S. Pourhaji aga golestani Tags: Posters 26 - 29 May, 2019 Source Type: research
The association of adjusted Global AntiphosPholipid Syndrome Score (aGAPSS) with cardiovascular disease in subjects with antiphospholipid antibodies
Cardiovascular disease (CVD), including coronary artery disease and stroke/peripheral artery disease, is less commonly reported than venous thromboembolism in subjects with antiphospholipid antibodies (aPLs) and little is known about the association of CVD with adjusted Global AntiphosPholipid Syndrome Score (aGAPSS).
Source: Atherosclerosis - September 14, 2018 Category: Cardiology Authors: Matteo Nicola Dario Di Minno, Antonella Scalera, Antonella Tufano, Pasquale Ambrosino, Alessandra Bettiol, Elena Silvestri, Giacomo Emmi, Domenico Prisco Source Type: research
Photomechanical effect of Q-switched ND:YAG laser enhance thrombolysis using of PLGA- based encapsulated tissue plasminogen activator (TPA) nanoparticles
Aim: Thrombus formation on a disrupted atherosclerotic plaque is a key event that leads to atherothrombosis. Atherothrombosis mediated acute clinical events such as myocardial infarction and stroke. The purpose of this study is to prepare encapsulated tissue plasminogen activator (tPA) and evaluate its effectiveness on thrombolysis using laser therapy in the rabbit model of atherothrombotic.
Source: Atherosclerosis - August 1, 2018 Category: Cardiology Authors: H. Mehrad, J. Mahmoudi, A. Keshavarz, A. Rahimkhani Source Type: research
Atherosclerotic intracranial internal carotid artery calcification and intravenous thrombolytic therapy for acute ischemic stroke
Intracranial internal carotid artery calcification (IICAC) is a frequent and readily available finding in acute stroke patients treated with intravenous (IV) tissue plasminogen activator (tPA). We aimed to investigate the effects of IICAC subtype (medial and intimal) on the response to IV tPA.
Source: Atherosclerosis - January 31, 2018 Category: Cardiology Authors: Rahsan Gocmen, Ethem Murat Arsava, Kader Karli Oguz, Mehmet Akif Topcuoglu Source Type: research
Relationship between thrombus age in aspirated coronary material and mid-term major adverse cardiac and cerebrovascular events in patients with acute myocardial infarction
Recent studies have shown that coronary thrombus histopathology is associated with impaired myocardial reperfusion and poor clinical outcome in patients with acute myocardial infarction (AMI). We sought to investigate the age of thrombi aspirated during percutaneous coronary intervention (PCI) in patients with AMI and evaluate the relationship between histopathologic findings and major adverse cardiac and cerebrovascular events (MACCEs) defined as all-cause death, stroke, or myocardial infarction within 6 months of PCI.
Source: Atherosclerosis - December 2, 2017 Category: Cardiology Authors: Kensaku Nishihira, Yoshisato Shibata, Atsushi Yamashita, Nehiro Kuriyama, Yujiro Asada Source Type: research
Inertial cavitation effect of catheter- based Q-switched ND:YAG laser enhance extracorporeal pulsed- focused ultrasound thrombolysis
Aim: A plaque may rupture with high risk of subsequent thrombus- mediated acute clinical events such as myocardial infarction and stroke. Catheter-based lasers have been extensively studied as an effective method to treat thrombosis. Focused ultrasound is one of the non- invasive methods to treat abnormal tissues. In pulsed- focused ultrasound with low duty cycle, which is used for thrombolysis, energy deposition rates are low enough that temperature rises are well below the threshold for thermal damage.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Hossein Mehrad, Mehdi Farhoudi, Alireza Paknezhad Source Type: research
Secretory phospholipase A2 modified high-density lipoprotein potently suppresses platelet activation
Aim: Levels of secretory phospholipases A2 (sPLA2) highly increase under acute and chronic inflammatory conditions. sPLA2 is mainly associated with high-density lipoproteins (HDL) and generates bioactive lysophospholipids implicated in acute and chronic inflammatory processes. Unexpectedly, pharmacological inhibition of sPLA2 in patients with acute coronary syndrome was associated with an increased risk of myocardial infarction and stroke. Given that platelets are key players in thrombosis and inflammation, we hypothesized that sPLA2-induced hydrolysis of HDL-associated phospholipids (sPLA2-HDL) generates modified HDL part...
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Gunther Marsche, Michael Holzer, Sanja Curcic Source Type: research
Promoter hypomethylation of microRNA223 gene is associated with atherosclerotic cerebral infarction
microRNA223 (miR-223) plays an important role in the development of atherosclerosis and ischemic stroke. It is involved in regulation of multiple physiological and pathophysiological processes such as cholesterol metabolism, endothelial cell (EC) function, and thrombosis. Here we investigated the role of methylation regulation of MIR-223 promoter region in atherosclerotic cerebral infarction (ACI) patients.
Source: Atherosclerosis - June 27, 2017 Category: Cardiology Authors: Zhibin Li, Fang Yu, Xiaoqing Zhou, Sian Zeng, Qiong Zhan, Mei Yuan, Qidong Yang, Yunhai Liu, Jian Xia Source Type: research
Ischaemic stroke and liver fibrosis
Stroke is the sudden onset of acute neurological injury arising as a result of cerebral haemorrhage or ischaemia. It is common and serious, with 16.9 million incident strokes deduced to have occurred in 2010 causing 5.9 million deaths worldwide. It is also a major cause of disability, incurring a significant healthcare burden. Ischaemic stroke is responsible for about 80% of cases in the developed world. Focal ischaemia results from blockage of a blood vessel by a thrombus or embolus, preventing blood supply to a region of the brain [1].
Source: Atherosclerosis - March 22, 2017 Category: Cardiology Authors: Ann P. Walker Tags: Editorial Source Type: research
