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Condition: Stroke
Drug: Verapamil

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Total 38 results found since Jan 2013.

O-031 Combinational therapy following elvo in a mouse model of stroke demonstrates new frontiers in neuroprotection: the mavaric trial
Stroke remains a leading cause of morbidity and mortality in the United States. Potential therapies have encountered significant barriers in attempts to translate bench to bedside research. Because of this, we have evaluated novel roles for FDA approved drugs, repurposed for treating stroke. Two such drugs, verapamil and magnesium, represent drug classes with a long history in neuroprotection trials with mixed results. Using an intra-arterial (IA) model developed in our lab, we selectively delivered our agents of interest to the stroke affected region following experimental stroke and successful recanalization. In addition...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Maniskas, M., Trout, A., Goodman, J., Bix, G., Fraser, J. Tags: Oral Abstracts Source Type: research

E-062 transradial access for acute interventional stroke therapy
ConclusionTransradial artery access for neuro-interventional procedures is rarely considered today. Our small case study suggests that transradial access is safe and efficacious in advance stroke therapy. Further studies with larger sample size are needed.DisclosuresJ. Farkas: None. K. Sivakumar: None. T. Sabharwal: None. H. Dababneh: None. A. Tiwari: None. K. Arcot: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Farkas, J., Sivakumar, K., Sabharwal, T., Dababneh, H., Tiwari, A., Arcot, K. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

Intra-arterial verapamil improves functional outcomes of thrombectomy in a preclinical model of extended hyperglycemic stroke
The abrupt hyperglycemic reperfusion following thrombectomy has been shown to harm the efficacy of the intervention in stroke patients with large vessel occlusion. Studies of ours and others have shown thioredoxin-interacting protein (TXNIP) is critically involved in hyperglycemic stroke injury. We recently found verapamil ameliorates cerebrovascular toxicity of tissue plasminogen activators in hyperglycemic stroke. The present study aims to answer if verapamil exerts direct neuroprotective effects and alleviates glucose toxicity following thrombectomy in a preclinical model of hyperglycemic stroke. Primary cortical neural...
Source: Frontiers in Pharmacology - April 13, 2023 Category: Drugs & Pharmacology Source Type: research

S-oxiracetam protect against ischemic stroke via alleviating blood brain barrier dysfunction in rats.
In conclusion, the present study demonstrates that post-treatment of S-ORC alleviates BBB dysfunction by regulating tight junction proteins (TJPs), upregulating P-glycoprotein function, and protects against ischemic stroke as results. PMID: 28760594 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - July 28, 2017 Category: Drugs & Pharmacology Authors: Huang L, Shang E, Fan W, Li X, Li B, He S, Fu Y, Zhang Y, Li Y, Fang W Tags: Eur J Pharm Sci Source Type: research

O-042 Incidence of periprocedural stroke with radial access for diagnostic cerebral angiograms
ConclusionIn our experience, transradial access for diagnostic cerebral angiograms was associated with a low but not neglectable incidence of periprocedural strokes when compared to the traditional femoral approach. Patient vascular anatomy should be evaluated prior to selection of vascular access and patients should be made aware of the possibility of a slightly higher possibility of periprocedural stroke with transradial access.Abstract O-042 Table 1 Patient Age Access Vessels catheterized Catheter used Radial Medication Contrast Fluoro Time Platelet Count INR GFR COVID Status Stroke Symptoms NIHSS Imaging performed 1 5...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Kuhn, A., Singh, J., de Macedo Rodrigues, K., Massari, F., Puri, A. Tags: SNIS 19th annual meeting oral abstracts Source Type: research

Intra-arterial neuroprotective therapy as an adjunct to endovascular intervention in acute ischemic stroke: A review of the literature and future directions.
Authors: Link TW, Santillan A, Patsalides A Abstract Mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion has been shown to significantly improve outcomes. However, despite efficient rates of recanalization (60-90%), the rates of functional independence remain suboptimal (14-58%), most likely due to pathways of cell death in the brain that have already committed despite successful reperfusion. Pharmacologic neuroprotection provides a potential means of preventing this inevitable damage through targeting excitotoxicity, reactive oxygen species, cellular apoptosis, and inflammation. Numerou...
Source: Interventional Neuroradiology - May 21, 2020 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Multimodal Imaging in Rats Reveals Impaired Neurovascular Coupling in Sustained Hypertension Basic Sciences
Conclusions— Impaired neurovascular coupling in the SHR evolves upon sustained hypertension. Antihypertensive monotherapy using verapamil or losartan is not sufficient to abolish this functional impairment. These deficits in neurovascular coupling in response to sustained hypertension might contribute to accelerate progression of neurodegenerative diseases in chronic hypertension.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Calcinaghi, N., Wyss, M. T., Jolivet, R., Singh, A., Keller, A. L., Winnik, S., Fritschy, J.-M., Buck, A., Matter, C. M., Weber, B. Tags: Animal models of human disease, Brain Circulation and Metabolism, Other imaging Basic Sciences Source Type: research

Target Blood Pressure in Patients with Diabetes: Asian Perspective.
In conclusion, hypertension, in association with diabetes, has been found to be significantly correlated with an elevated risk for cardiovascular events. As the association between stroke and BP is stronger in Asians, compared to other ethnicities, consideration should be given for a target BP of 130/80 mm Hg in Asians. PMID: 27593856 [PubMed - in process]
Source: Yonsei Medical Journal - September 7, 2016 Category: Universities & Medical Training Authors: Park S, Kario K, Park CG, Huang QF, Cheng HM, Hoshide S, Wang JG, Chen CH, Characteristics On the ManagEment of Hypertension in Asia-Morning Hypertension Discussion Group (COME Asia MHDG) Tags: Yonsei Med J Source Type: research

E-228 Single center experience using 3mm trevo stent retrievers in medium vessel occlusion thrombectomy
ConclusionUse of 3mm Trevo NXT stent retriever in medium vessel occlusion for first line and rescue thrombectomy in our single center experience demonstrated an adequate safety and efficacy profile, thus endorsing its use in mechanical thrombectomy applications beyond large vessel occlusion cases. Future multicenter studies will build upon this initial experience to further characterize the utility of novel stent retrievers in medium vessel occlusions.Disclosures C. Zhao: None. M. Koneru: None. J. Siegler: None. N. Vigilante: None. J. Khalife: None. D. Tonetti: None. H. Shaikh: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Zhao, C., Koneru, M., Siegler, J., Vigilante, N., Khalife, J., Tonetti, D., Shaikh, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

Association between Use of Pharmacokinetic-Interacting Drugs and Effectiveness and Safety of Direct Acting Oral Anticoagulants: Nested Case-Control Study
Clin Pharmacol Ther. 2021 Jul 19. doi: 10.1002/cpt.2369. Online ahead of print.ABSTRACTConcomitant use of direct oral anticoagulants (DOACs) and medications with inhibition/induction effect on P-gp/CYP3A might increase risk of bleeding/treatment failure, respectively. We designed a nested case-control study within a Clalit cohort of atrial fibrillation (AF) patients and a cohort of venous thromboembolic patients, new users of a DOAC (1.1.2010-24.8.2020). Propensity scores were constructed from demographic, clinical and medications at cohort entry. Each case of: 1) serious bleeding event; 2) stroke/systemic emboli (SE) in A...
Source: Clinical Pharmacology and Therapeutics - July 21, 2021 Category: Drugs & Pharmacology Authors: Naomi Gronich Nilli Stein Mordehcai Muszkat Source Type: research

Acute Intravenous Calcium Antagonist for Suspected Hemiplegic Migraine – A Case Story
We present a 28-year-old woman with a suspected hemiplegic migraine attack with left-sided hemiparalysis. Brain CT with perfusion imaging 1 h 54 min after symptom onset revealed hypoperfusion in the right hemisphere. The patient was treated with intravenous recombinant tissue plasminogen activator (rtPA) with no effect. After a subsequent intravenous verapamil infusion, the patient gained full motor function within 10 min. Brain magnetic resonance imaging (MRI) performed 5 h 46 min after symptom onset revealed diffusion restriction in the same area as the hypoperfusion on CT. There were no notable changes on T2 images. The...
Source: Case Reports in Neurology - May 5, 2017 Category: Neurology Source Type: research

Simple Integer Risk Score to Determine Prognosis of Patients With Hypertension and Chronic Stable Coronary Artery Disease Coronary Heart Disease
Conclusion Readily available clinical variables can rapidly stratify patients with hypertension and chronic stable CAD into useful risk categories.
Source: JAHA:Journal of the American Heart Association - August 15, 2013 Category: Cardiology Authors: Bavry, A. A., Kumbhani, D. J., Gong, Y., Handberg, E. M., Cooper-DeHoff, R. M., Pepine, C. J. Tags: Coronary Heart Disease Source Type: research