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Condition: Cardiac Arrhythmia
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Total 852 results found since Jan 2013.
PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
CONCLUSIONS: Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.PMID:37737016 | DOI:10.1161/CIRCRESAHA.123.322516
Source: Circulation Research - September 22, 2023 Category: Cardiology Authors: Srikanth Perike Francisco J Gonzalez-Gonzalez Issam Abu-Taha Frederick W Damen Laurin M Hanft Ken S Lizama Anahita Aboonabi Andrielle E Capote Yuriana Aguilar-Sanchez Benjamin Levin Zhenbo Han Arvind Sridhar Jacob Grand Jody Martin Joseph G Akar Chad M Wa Source Type: research
Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study
CONCLUSION: These results suggest that atypical antipsychotics and haloperidol have similar rates of in-hospital adverse clinical events in older patients with postoperative delirium who receive an oral low-to-moderate dose antipsychotic drug.PRIMARY FUNDING SOURCE: National Institute on Aging.PMID:37665998 | DOI:10.7326/M22-3021
Source: Annals of Internal Medicine - September 4, 2023 Category: Internal Medicine Authors: Dae Hyun Kim Su Been Lee Chan Mi Park Raisa Levin Eran Metzger Brian T Bateman E Wesley Ely Pratik P Pandharipande Margaret A Pisani Richard N Jones Edward R Marcantonio Sharon K Inouye Source Type: research
Insomnia and Cardiovascular Health: Exploring the Link Between Sleep Disorders and Cardiac Arrhythmias
AbstractCardiovascular diseases (CVDs), driven by modern lifestyles, have increased, with atrial fibrillation (AF) being a major concern linked to heart failure and stroke. Insomnia affects a large population, especially younger individuals, males, and menopausal women, decreasing the quality of life and potentially causing autonomic disturbances and cardiac arrhythmias.Purpose of ReviewThis review explores the link between insomnia and cardiac arrhythmias, particularly AF, and its impact on cardiovascular health and emphasizes the need to address insomnia in individuals with cardiac arrhythmias by tailored strategies for ...
Source: Current Cardiology Reports - September 1, 2023 Category: Cardiology Source Type: research
The Price of Keeping the Rhythm: Increased Bleeding Risk in Patients with Atrial Fibrillation Concurrently Prescribed Amiodarone and Factor Xa Inhibitors
Atrial fibrillation is the most common sustained cardiac arrhythmia affecting nearly 2% of the population of the United States.1 Patients with atrial fibrillation are twice as likely to have a myocardial infarction and five-times as likely to have a stroke.1 Current guidelines recommend antiarrhythmic pharmacotherapy in patients with symptomatic atrial fibrillation as first-line management.2-4 Amiodarone is a very effective, and therefore, a commonly prescribed agent for this purpose.5 Anticoagulation is a key tenet in the management of atrial fibrillation due to the increased tendency of left atrial appendage clot formati...
Source: Journal of Cardiothoracic and Vascular Anesthesia - August 10, 2023 Category: Anesthesiology Authors: Nicolas Kumar, Manoj H. Iyer, Adam Dalia, Amit Bardia Tags: Editorial Source Type: research
Sex Differences in Atrial Fibrillation
AbstractPurpose of ReviewAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The estimated lifetime risk of developing AF is higher in men; however, due to differences in life expectancy, the overall prevalence is higher among women, particularly in the older age group. Sex differences play an important role in the pathophysiology, presentation, and clinical outcomes of AF. Awareness of these differences minimizes the potential for disparities in AF management. Our review summarizes the current literature on sex differences in AF, including the epidemiology, pathophysiology, risk factors, clinical sym...
Source: Current Cardiology Reports - July 28, 2023 Category: Cardiology Source Type: research
Major adverse cardiovascular events associated with testosterone treatment: a pharmacovigilance study of the FAERS database
Conclusion: For myocardial infarction and cardiomyopathy, TRT statistically tended to increase the risk of MACEs, while for cardiac arrhythmia, cardiac failure, and stroke, TRT demonstrated beneficial effects among the population with morbidities, such as testosterone deficiency (TD), diabetes mellitus (DM), and hypertension. MACEs were rare but led to serious outcomes including significant increase in death and disability. Since 2018, and before 2014, reports referring to TRT associated with MACEs were relatively scarce, which indicated that there might be a considerable number of cases that went unrecorded, due to neglec...
Source: Frontiers in Pharmacology - July 12, 2023 Category: Drugs & Pharmacology Source Type: research
Association between polymorphisms in Connexin40 Gene (Cx40) and risk of atrial fibrillation: a meta-analysis based on 3, 452 subjects
CONCLUSION: The Cx40 polymorphisms were positively associated with AF in both populations, especially on -44 polymorphism.PMID:37382580 | DOI:10.1080/1354750X.2023.2227361
Source: Biomarkers - June 29, 2023 Category: Research Authors: Zheng Lian Zheng Ma Zhi-Li Zhang Pei-Lin Liu Guo-Yong Zhang Cai-Xia Guo Source Type: research
