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The Influence Of Obesity On Outcomes After Intravenous Thrombolysis For Acute Ischemic Stroke (P5.007)
Conclusion: Obese patients receiving IV t-PA treatment for acute ischemic stroke had similar rates of in-hospital mortality, discharge to home and sICH, but they had longer LOS and rates of UTI. Future studies should be undertaken to determine if the clinical efficacy of tPA is affected by under-dosing focusing on both radiographic recanalization rates and functional clinical outcomes.Disclosure: Dr. Nickles has nothing to disclose. Dr. Chaudry has nothing to disclose. Dr. Hussain has nothing to disclose. Dr. Reeves has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Nickles, A., Chaudry, S., Hussain, S., Reeves, M. J. Tags: Cerebrovascular Disease and Interventional Neurology II Source Type: research

Revascularization in Acute Ischemic Stroke Based on Clinical-Diffusion Mismatch (REVASC): A Planned Phase I Trial (P1.134)
CONCLUSIONS:Acute stroke intervention performed beyond 8 hours may be safe among patients fulfilling CDM criteria. This study will further help establish safety.Disclosure: Dr. Janjua has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Janjua, N. Tags: Cerebrovascular Disease and Interventional Neurology: Atrial Fibrillation and Miscellaneous Source Type: research

Functional Outcome After Perinatal Cerebral Sinovenous Thrombosis: A Prospective Cohort Study (S42.006)
CONCLUSIONS: We found a high rate of neurological morbidity and seizure burden after perinatal CSVT which significantly impacted achievement of age-appropriate developmental milestones and function. Measures and predictors of functional outcome following perinatal CSVT need further exploration.Disclosure: Dr. Billinghurst has nothing to disclose. Dr. Uohara has nothing to disclose. Dr. Licht has nothing to disclose. Dr. Ichord has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Billinghurst, L., Uohara, M., Licht, D., Ichord, R. Tags: Child Neurology I Source Type: research

Left Ventricular Hypertrophy as a Predictor of White Matter Hyperintensities in Young Stroke Patients (P2.111)
CONCLUSIONS: A large proportion of WMH in our cohort is hypertensive. Our preliminary data suggest that LVH may aid in determining the pathophysiology underlying WMH in young adults with stroke, independent from HTN. Further analyses are needed to confirm our findings.Study Supported by: NoneDisclosure: Dr. Catanese has nothing to disclose. Dr. Shoamanesh has nothing to disclose. Dr. Lau has nothing to disclose. Dr. Romero has nothing to disclose. Dr. Babikian has nothing to disclose. Dr. Kase has nothing to disclose. Dr. Pikula has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Catanese, L., Shoamanesh, A., Lau, H., Romero, J., Babikian, V., Kase, C., Pikula, A. Tags: Cerebrovascular Disease and Interventional Neurology: Childhood and Young Adult Source Type: research

Thrombectomy with the Penumbra 5 MAX ACE Achieves More Efficient Recanalization (P6.273)
CONCLUSIONS:The 5 MAX ACE yields more efficient revascularization (greater reperfusion achieved in significantly shorter procedural times), with minimal vessel trauma and resultant hemorrhage and greater decline in neurological dysfunction at discharge.Disclosure: Dr. Janjua has nothing to disclose. Dr. Farkas has nothing to disclose. Dr. Arcot has nothing to disclose. Dr. Kumar has nothing to disclose. Dr. Jean has nothing to disclose. Dr. Papamitsakis has nothing to disclose. Dr. Margulis has nothing to disclose. Dr. Dash has nothing to disclose. Dr. Levin has nothing to disclose. Dr. Azhar has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Janjua, N., Farkas, J., Arcot, K., Kumar, R., Jean, D., Papamitsakis, N., Margulis, Y., Dash, S., Levin, K., Azhar, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Hemothorax after the intravenous administration of tissue plasminogen activator in a patient with acute ischemic stroke and rib fractures.
Abstract A 79-year-old man experienced sudden-onset left hemiparesis and disturbance of consciousness. Diffusion-weighted magnetic resonance imaging showed an acute ischemic stroke in the territory of the right middle cerebral artery. He underwent systemic thrombolysis via the intravenous administration of tissue plasminogen activator (t-PA). Chest radiography and computed tomography performed the following day showed severe hemothorax with atelectasis of the left lung and multiple rib fractures; the initial chest radiogram had revealed rib fractures but we did not recognize them at the time. Conservative treatmen...
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Shirokane K, Umeoka K, Mishina M, Mizunari T, Kobayashi S, Teramoto A Tags: J Nippon Med Sch Source Type: research

Impaired Cerebral Autoregulation Is Associated With Vasospasm and Delayed Cerebral Ischemia in Subarachnoid Hemorrhage Clinical Sciences
Conclusions— Dynamic cerebral autoregulation is impaired in the early days after SAH. Including autoregulation as part of the initial clinical and radiographic assessment may enhance our ability to identify patients at a high risk for developing secondary complications after SAH.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Otite, F., Mink, S., Tan, C. O., Puri, A., Zamani, A. A., Mehregan, A., Chou, S., Orzell, S., Purkayastha, S., Du, R., Sorond, F. A. Tags: Other diagnostic testing, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Doppler ultrasound, Transcranial Doppler etc., Other Research Clinical Sciences Source Type: research

Treatment of moyamoya disease in the adult population with pial synangiosis.
Conclusions Pial synangiosis is a safe and durable method of cerebral revascularization in adult patients with moyamoya and can be considered as a potential treatment option for moyamoya disease in adults. PMID: 24405066 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 3, 2014 Category: Neurosurgery Authors: Lin N, Aronson JP, Manjila S, Smith ER, Scott RM Tags: J Neurosurg Source Type: research

The relationship between ruptured aneurysm location, subarachnoid hemorrhage clot thickness, and incidence of radiographic or symptomatic vasospasm in patients enrolled in a prospective randomized controlled trial.
Conclusions The location of a ruptured aneurysm minimally affects the maximum thickness of the SAH clot but is predictive of symptomatic vasospasm or clinical deterioration from delayed cerebral ischemia in pericallosal aneurysms. The worst 1-year mRS outcomes in this cohort of patients were noted in those with posterior circulation aneurysms or pericallosal artery aneurysms. Patients experiencing stroke had higher mean clot burden. PMID: 24313610 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - December 6, 2013 Category: Neurosurgery Authors: Abla AA, Wilson DA, Williamson RW, Nakaji P, McDougall CG, Zabramski JM, Albuquerque FC, Spetzler RF Tags: J Neurosurg Source Type: research

Endovascular Therapy for Asymptomatic Unruptured Intracranial Aneurysms: JR-NET and JR-NET2 Findings Clinical Sciences
Conclusions— The radiographic results of EVT for asymptomatic UIAs in Japan were acceptable, with low mortality and morbidity rates.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Shigematsu, T., Fujinaka, T., Yoshimine, T., Imamura, H., Ishii, A., Sakai, C., Sakai, N., for the JR-NET Investigators Tags: Aneurysm, AVM, hematoma Clinical Sciences Source Type: research

Prospective, Randomized, Open-Label Phase II Trial on Concomitant Intraventricular Fibrinolysis and Low-Frequency Rotation After Severe Subarachnoid Hemorrhage Clinical Sciences
Conclusions— Despite the ineffectiveness on reduction of delayed cerebral ischemia or poor functional outcome, intraventricular fibrinolysis and kinetic therapy seems to be a safe and effective concept for therapeutic reduction of subarachnoid clot in a patient collective experiencing predominately severe subarachnoid hemorrhage. Therefore, future studies should investigate this treatment in a larger patient collective with a lower degree of primary brain injury and until full clot clearance on serial imaging. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ICRCTN13230264.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Etminan, N., Beseoglu, K., Eicker, S. O., Turowski, B., Steiger, H.-J., Hanggi, D. Tags: Emergency treatment of Stroke, Antiplatelets, Thrombolysis Clinical Sciences Source Type: research

Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies
Conclusions Data from the current study indicate that an H2-enriched intravenous solution is safe for patients with acute cerebral infarction, including patients treated with t-PA.
Source: Medical Gas Research - June 25, 2013 Category: Biomedical Science Source Type: research

Pooled Assessment of Computed Tomography Interpretation by Vascular Neurologists in the STRokE DOC Telestroke Network
Conclusions: Both vascular neurologists and reports from spoke radiologists had excellent reliability in identifying radiologic rt-PA contraindications. These pooled findings demonstrate that telestroke evaluation of head CT scans for acute rt-PA assessments is reliable.
Source: Journal of Stroke and Cerebrovascular Diseases - May 21, 2013 Category: Neurology Authors: Ilana Spokoyny, Rema Raman, Karin Ernstrom, Bart M. Demaerschalk, Patrick D. Lyden, Thomas M. Hemmen, Amy K. Guzik, James Y. Chen, Brett C. Meyer Tags: Original Articles Source Type: research

Clinical risk predictors for cerebral hyperperfusion syndrome after carotid endarterectomy
Conclusions Independent, prospective monitoring of a large cohort of CEA cases identified a brief time interval between ischaemic symptoms and endarterectomy as the clearest risk factor for CHS.
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 8, 2013 Category: Neurosurgery Authors: Maas, M. B., Kwolek, C. J., Hirsch, J. A., Jaff, M. R., Rordorf, G. A. Tags: Epilepsy and seizures, Headache (including migraine), Pain (neurology), Stroke, Hypertension, Ophthalmology, Ischaemic heart disease, Disability Neurosurgery Source Type: research

Is There an Increased Risk of Intracranial Hemorrhage When Treating Patients Who Are Currently on Dual Anti-Platelets with IV tPA? (P01.233)
CONCLUSIONS: In our cohort, there was no additional risk of hemorrhagic complications in patients on dual antiplatelet therapy who received IVtPA, prospective studies are needed to confirm this finding.Disclosure: Dr. Kung has nothing to disclose. Dr. Korsnack has nothing to disclose. Dr. Zaidi has nothing to disclose. Dr. Jumaa has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Kung, V., Korsnack, A., Zaidi, S., Jumaa, M. Tags: P01 Cerebrovascular Disease I Source Type: research

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