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Condition: Hemorrhagic Stroke
Therapy: Thrombolytic Therapy

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Total 340 results found since Jan 2013.

Acute ischemic stroke: The role of emergency carotid endarterectomy in isolated extracranial internal carotid artery occlusion
CONCLUSIONS: Emergency CEA in isolated eICA occlusion has proved to be a safe and effective treatment option in selected patients. CT perfusion, imaging the ischemic penumbra and quantifying the tissue suitable for reperfusion, offers a valid support in the diagnostic-therapeutic workup. Indeed, we can infer that the area of the ischemic penumbra is directly proportional to the margin of clinical improvement after revascularization, supposing that the appropriate intervention timing is respect.PMID:37594376 | DOI:10.1177/17085381231192712
Source: Vascular - August 18, 2023 Category: Surgery Authors: Pierfilippo Acciarri Alice Camagni Maddalena Bressan Gladiol Zenunaj Ilaria Casetta Andrea Bernardoni Vincenzo Gasbarro Luca Traina Source Type: research

Factors influencing nonadministration of thrombolytic therapy in early arrival strokes in a university hospital in Hyderabad, India
Conclusion: One-fourth of early ischemic stroke patients in our study were not thrombolyzed even though they arrived within the window period. The majority of the reasons for nonadministration of thrombolysis were potentially preventable, such as nonaffordability, intrahospital delay, and nonavailability of newer endovascular interventions.
Source: Annals of Indian Academy of Neurology - July 24, 2016 Category: Neurology Authors: Lalitha Pidaparthi Anitha Kotha Venkat Reddy Aleti Abhijeet Kumar Kohat Mridula R Kandadai Suryaprabha Turaga Jabeen A Shaik Suvarna Alladi Meena A Kanikannan Borgohain Rupam Subhash Kaul Source Type: research

A Systematic Review and Meta-analysis of Peri-Procedural Outcomes in Patients Undergoing Carotid Interventions Following Thrombolysis
CONCLUSION: Peri-procedural ICH and local haematoma were significantly more frequent in patients undergoing CEA after TT (vs. no TT), although there were no randomised comparisons. Peri-procedural hazards were also significantly higher for CAS after TT. The inverse relationship between timing to CEA and peri-procedural stroke/death mandates careful patient selection and suggests that it may be safer to defer CEA for six-seven days after TT.PMID:34266765 | DOI:10.1016/j.ejvs.2021.06.003
Source: PubMed: Eur J Vasc Endovasc ... - July 16, 2021 Category: Surgery Authors: Stavros K Kakkos Melina Vega de Ceniga Ross Naylor Source Type: research

Comparison of 8 Scores for predicting Symptomatic Intracerebral Hemorrhage after IV Thrombolysis
Conclusions Three scores showed good agreement with sICH: DRAGON, Stroke-TPI, and HAT with odds ratios substantially greater than 1. Stroke-TPI and HAT additionally benefited from low computational complexity and therefore performed best overall. Our results demonstrate the utility of clinical scores as predictors of sICH in acute ischemic stroke patients undergoing IV thrombolytic therapy.
Source: Neurocritical Care - March 18, 2015 Category: Neurology Source Type: research

The establishment of a telestroke service using multimodal CT imaging decision assistance: “Turning on the fog lights”
Publication date: March 2017 Source:Journal of Clinical Neuroscience, Volume 37 Author(s): Jelle Demeestere, Claire Sewell, Jennifer Rudd, Timothy Ang, Louise Jordan, James Wills, Carlos Garcia-Esperon, Ferdinand Miteff, Venkatesh Krishnamurthy, Neil Spratt, Longting Lin, Andrew Bivard, Mark Parsons, Christopher Levi Telestroke services have been shown to increase stroke therapy access in rural areas. The implementation of advanced CT imaging for patient assessment may improve patient selection and detection of stroke mimics in conjunction with telestroke. We implemented a telestroke service supported by multimodal CT ima...
Source: Journal of Clinical Neuroscience - January 31, 2017 Category: Neuroscience Source Type: research

Predicting a post‐thrombolysis intracerebral hemorrhage: a systematic review
ConclusionsThe development and clinical application of ICH risk scores remains a developing field. Extensive external validation and impact studies are needed to strengthen evidence regarding their utility for improving the selection of ischemic stroke victims for thrombolysis while mitigating risks of complications through post‐thrombolysis ICH.
Source: Journal of Thrombosis and Haemostasis - May 15, 2013 Category: Hematology Authors: J. B. Echouffo‐Tcheugui, M. Woodward, A. P. Kengne Tags: Original Article Source Type: research

Early Ischemic Blood Brain Barrier Damage: A Potential Indicator for Hemorrhagic Transformation Following Tissue Plasminogen Activator (tPA) Thrombolysis?
Abstract Tissue plasminogen activator (tPA) thrombolysis, remains the only United States Food and Drug Administration(FDA) approvedtreatmentfor acute ischemia stroke. However, the use of tPA has been profoundly constraineddue to its narrow therapeutic time window and the increased risk of potentially deadly hemorrhagic complications. TPA-associated hemorrhagic transformation (HT) often occurs as a result of catastrophic failure of theblood brain barrier (BBB), wherein the affected cerebral capillaries can no longer hold blood constituents.Due to its direct contribution to edema and HT, reperfusion-associated BBB d...
Source: Current Neurovascular Research - May 30, 2014 Category: Neurology Authors: Jin X, Liu J, Liu W Tags: Curr Neurovasc Res Source Type: research

International benchmarking for acute thrombolytic therapy implementation in Australia and Japan
Publication date: July 2016 Source:Journal of Clinical Neuroscience, Volume 29 Author(s): Hiroyuki Kawano, Christopher Levi, Yuichiro Inatomi, Heather Pagram, Erin Kerr, Andrew Bivard, Neil Spratt, Ferdinand Miteff, Toshiro Yonehara, Yukio Ando, Mark Parsons Although a wide range of strategies have been established to improve intravenous tissue plasminogen activator (IV-tPA) treatment rates, international benchmarking has not been regularly used as a systems improvement tool. We compared acute stroke codes (ASC) between two hospitals in Australia and Japan to study the activation process and potentially improv...
Source: Journal of Clinical Neuroscience - May 29, 2016 Category: Neuroscience Source Type: research

Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma
In conclusion, we identified single nucleotide variants in theZBTB46 gene associated with a higher risk of parenchymal haematoma following recombinant tissue-plasminogen activator treatment.
Source: Brain - March 16, 2021 Category: Neurology Source Type: research

The SON2A2 score: A novel grading scale for predicting hemorrhage and outcomes after thrombolysis
ConclusionThe SON2A2 score is a simple, efficient, quick, and easy-to-perform scale for predicting the risk of sICH and outcome after intravenous r-tPA thrombolysis within 4.5 h in patients with ischemic stroke, and risk assessment using this test has the potential for early and personalized management of this disease in high-risk patients.
Source: Frontiers in Neurology - October 31, 2022 Category: Neurology Source Type: research

Predicting post‐thrombolysis intracerebral hemorrhage: A systematic review
Abstract ObjectivesFear of intracerebral hemorrhage (ICH) is a deterrent to the uptake of thrombolytic therapy, an evidence‐based treatment for acute ischemic stroke. Several characteristics associated with post‐thrombolysis ICH have been identified, but their combined utility for risk stratification has yet to be clarified. We critically examined risk models to predict post‐thrombolysis ICH, and evaluated their potential clinical utility. MethodsMEDLINE (Inception to October 2012) was searched and bibliographies of retrieved articles examined. Inclusion and exclusion criteria of each study were reviewed. Eligible st...
Source: Journal of Thrombosis and Haemostasis - March 7, 2013 Category: Hematology Authors: J B. Echouffo‐Tcheugui, M Woodward, A P Kengne Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

HAT Score External Validity: A Predictor Of Hemorrhagic Transformation After Intravenous Thrombolysis (P3.107)
CONCLUSIONSThe consistency of the predictive capability of the scale in two great independent cohorts of t-PA-treated patients ( NINDS and HAT score ), and the presence of similar results in our cohort, indicate that this score is likely to have good external validity.Disclosure: Dr. Neto has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Neto, E. Tags: Cerebrovascular Disease and Interventional Neurology: t-PA Source Type: research

The Case Files: Traumatic Carotid Dissection
By Hsiao, Jonie MD   A 30-year-old man who was right-hand dominant presented 10 days after sustaining left-sided face and head trauma from a fall from a skateboard at an unknown speed. He lost consciousness for several seconds, and initially developed a headache with nausea and vomiting. A non-contrast head CT performed at another hospital done two days after the incident was reportedly negative.   He now presents primarily with concerns about the appearance of his left eye. He has notable anisocoria and a droopy eyelid. His left pupil is notably smaller, 2 mm, compared with the right eye, 5 mm. Both are reactive. The re...
Source: The Case Files - June 4, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: research