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Bioactive versus bare platinum coils for the endovascular treatment of intracranial aneurysms: systematic review and meta-analysis of randomized clinical trials
Conclusions Bioactive coils ensure a higher rate of medium-term complete aneurysm occlusion while reducing the rate of residual neck aneurysms compared with bare coiling in the mid-term. Hydrogel coils reduce residual aneurysms compared with bare coils. While there is level 1a evidence to show more complete aneurysm occlusion, longer term follow-up is needed to determine if this translates into clinical significance.
Source: Journal of NeuroInterventional Surgery - August 11, 2016 Category: Neurosurgery Authors: Broeders, J. A., Ahmed Ali, U., Molyneux, A. J., Poncyljusz, W., Raymond, J., White, P. M., Steinfort, B. Tags: Hemorrhagic stroke Source Type: research

Predictors of Outcome in Aneurysmal Subarachnoid Hemorrhage Patients Clinical Sciences
Background and Purpose—The mortality and morbidity after aneurysmal subarachnoid hemorrhage has improved because of better diagnosis, early treatment to secure the aneurysm, and better management of disease-specific complications. With these improvements in care, it is not clear if the previously identified independent predictors of a negative outcome have changed. The aim of this study was to identify the independent predictors of an unfavorable outcome (Glasgow Outcome Score 1, 2, and 3) in aneurysmal subarachnoid hemorrhage patients.Methods—Univariate and multivariate analysis of prospectively collected data on pati...
Source: Stroke - October 23, 2017 Category: Neurology Authors: James P. Galea, Louise Dulhanty, Hiren C. Patel Tags: Cerebral Aneurysm, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Endovascular flow diversion for treatment of anterior communicating artery region cerebral aneurysms: a single-center cohort of 50 cases
Conclusions The PED can be used safely and effectively in the treatment of aneurysms of the ACoA region. This represents a good alternative treatment option to microsurgical clipping and endovascular coiling.
Source: Journal of NeuroInterventional Surgery - June 16, 2017 Category: Neurosurgery Authors: Colby, G. P., Bender, M. T., Lin, L.-M., Beaty, N., Huang, J., Tamargo, R. J., Coon, A. L. Tags: Clinical neurology Hemorrhagic stroke Source Type: research

Place of interventional neuroradiology in the prevention of hemorrhagic stroke.
Abstract The risk of bleeding of unruptured aneurysms is increasing with aneurysm size. Small unruptured aneurysms can be treated conservatively with a regular MRI/MRA follow-up to detect a potential increase in size. If coiling is still the main endovascular technique for the treatment of unruptured aneurysms, several other techniques are now available including stent-assisted coiling, flow diversion, and flow disruption. After ARUBA study, there is no recommendation to treat unruptured brain AVMs. According to their hemorrhagic risk, dural arteriovenous fistulas with cortical venous drainage have to be treated, ...
Source: Presse Medicale - May 28, 2019 Category: General Medicine Authors: Pierot L Tags: Presse Med Source Type: research

A Nationwide Analysis of Aneurysmal Subarachnoid Hemorrhage Mortality, Complications, and Health Economics in the USA
In conclusion, patients with aSAH have high post-operative complication ra tes and costs. Development of novel interventions to reduce complications and improve outcomes is crucial.
Source: Translational Stroke Research - July 26, 2022 Category: Neurology Source Type: research

National trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study
Conclusions The 6-year trends indicated lower in-hospital mortality for patients with SAH (attributable to better outcomes), increased use of coiling and multidisciplinary care for untreated patients. Further increasing CSC capabilities may improve overall outcomes, mainly by increasing the use of coiling. Additional studies are necessary to determine the effect of confounders such as aneurysm complexity on outcomes of clipped patients in the modern endovascular era.
Source: BMJ Open - April 10, 2023 Category: General Medicine Authors: Kurogi, R., Kada, A., Ogasawara, K., Nishimura, K., Kitazono, T., Iwama, T., Matsumaru, Y., Sakai, N., Shiokawa, Y., Miyachi, S., Kuroda, S., Shimizu, H., Yoshimura, S., Osato, T., Horie, N., Nagata, I., Nozaki, K., Date, I., Hashimoto, Y., Hoshino, H., N Tags: Open access, Neurology Source Type: research

J & J ’ s Cerenovus launches Galaxy G3 mini embolic coil, touts Arise II Embotrap study data
Johnson & Johnson‘s (NYSE:JNJ) Cerenovus division this week announced the launch of its Galaxy G3 Mini embolic coil and released data from a study of its Embotrap device designed to remove clots from the brain following ischemic stroke. The Galaxy G3 Mini coils are designed to be approximately 25% softer than the Galaxy G3 xsft coils, with an ultra-low coil profile and a primary wind diameter of 0.009 inches, which Cerenovus said is the lowest profile available in its Spectra line. The newly launched coil is designed to have a random complex shape to make it comformable and enable the device to seek and fill open...
Source: Mass Device - January 26, 2018 Category: Medical Devices Authors: Fink Densford Tags: Blood Management Business/Financial News Catheters Clinical Trials Neurological Vascular cerenovus johnsonandjohnson Source Type: news

E-136 Morphology of mycotic aneurysms and outcomes
ConclusionPatients with secured mycotic aneurysms are less likely to have in-hospital mortality from postoperative hemorrhage and more likely to have better outcomes upon discharge. This snapshot study warrants further investigation to determine the optimal safe timing between securing IIAs to valvular surgery.Disclosures N. Krothapalli: None. M. Tsikvadze: None. N. Akram: None. A. Elmashad: None. N. Desai: None. A. Tunguturi: None. T. Mehta: None. S. Patel: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Krothapalli, N., Tsikvadze, M., Akram, N., Elmashad, A., Desai, N., Tunguturi, A., Mehta, T., Patel, S. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Timing and nature of in-house postoperative events following uncomplicated elective endovascular aneurysm treatment.
Conclusions The large majority of significant postprocedural events after uncomplicated endovascular aneurysm intervention occur within the first 4 hours; these events become less frequent with increasing time. Transfer to a floor bed after 4-12 hours for further observation is reasonable to consider in some patients. PMID: 25170666 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - August 29, 2014 Category: Neurosurgery Authors: Arias EJ, Patel B, Cross DT, Moran CJ, Dacey RG, Zipfel GJ, Derdeyn CP Tags: J Neurosurg Source Type: research

E-006 Familial Incidence of the Congenital Torcular Dural Arteriovenous Shunt
Purpose There are several hereditary disorders that are well known to be associated with arteriovenous malformations (AVMs) involving the central nervous system including Sturge-Weber, Klippel-Trenaunay-Weber, and Parkes-Weber syndromes as well as hereditary haemorrhagic telangiectasia and hereditary neurocutaneous angiomatosis. Furthermore, familial incidence of AVMs in the absence of congenital hereditary disorders also has been reported. Herein, we describe the occurrence of the giant torcular herophili (TH) dural arteriovenous fistula (AVF) in two pediatric cousins treated with endovascular embolization. Case report C...
Source: Journal of NeuroInterventional Surgery - July 26, 2014 Category: Neurosurgery Authors: Honarmand, A., Hurley, M., Daruwalla, V., Ansari, S., Shaibani, A. Tags: Electronic poster abstracts Source Type: research

E-056 Pipeline Endovascular Device for the Treatment of Intracranial Aneurysm at the Level of the Circle of Willis and Beyond: Multicenter Experience
Conclusion The PED provides a safe and effective solution for aneurysms at and beyond the circle of Willis. Preliminary results are promising but larger series with longer-term follow-up examinations are required to show the long-term safety and durability of this treatment alternative. Disclosures M. Martínez-Galdámez: 2; C; Covidien. I. Linfante: 2; C; Covidien, Stryker, Codman. E. Lin: None. G. Dabus: 2; C; Covidien, Microvention, Reverse Medical.
Source: Journal of NeuroInterventional Surgery - July 26, 2014 Category: Neurosurgery Authors: Martinez-Galdamez, M., Linfante, I., Lin, E., Dabus, G. Tags: Electronic poster abstracts Source Type: research

Surpass Flow Diverter in the Treatment of Intracranial Aneurysms: A Prospective Multicenter Study EVIDENCE-BASED MEDICINE LEVEL 2
CONCLUSIONS: Clinical outcomes of the Surpass flow diverter in the treatment of intracranial aneurysms show a safety profile that is comparable with that of stent-assisted coil embolization. Angiographic results showed a high rate of intracranial aneurysm occlusion.
Source: American Journal of Neuroradiology - January 13, 2015 Category: Radiology Authors: Wakhloo, A. K., Lylyk, P., de Vries, J., Taschner, C., Lundquist, J., Biondi, A., Hartmann, M., Szikora, I., Pierot, L., Sakai, N., Imamura, H., Sourour, N., Rennie, I., Skalej, M., Beuing, O., Bonafe, A., Mery, F., Turjman, F., Brouwer, P., Boccardi, E., Tags: EVIDENCE-BASED MEDICINE LEVEL 2 Source Type: research

Cerebrovascular neurosurgery 2014
Publication date: Available online 14 February 2015 Source:Journal of Clinical Neuroscience Author(s): Mohamed Salem , Bradley A. Gross , Rose Du , Ajith J. Thomas Continued advances in our understanding of the management of cerebrovascular disease were made in 2014. A randomized trial for management of unruptured brain arteriovenous malformation (ARUBA) (Mohr et al. Lancet 2014;383:614–21.) and the Scottish intracranial vascular malformation study (Al-Shahi Salman et al. JAMA 2014;311:1661–9) were published and contrasted with reports based on extensive surgical experience. We highlight the results from the simvasta...
Source: Journal of Clinical Neuroscience - February 16, 2015 Category: Neuroscience Source Type: research

Apolipoprotein E polymorphism in aneurysmal subarachnoid haemorrhage in West Sweden
ConclusionsThe APOEε4 polymorphism has no major influence on risk of aSAH, the occurrence of CVS or long‐term neurological outcome after aSAH.
Source: Acta Neurologica Scandinavica - September 16, 2015 Category: Neurology Authors: L. Z. Csajbok, K. Nylén, M. Öst, K. Blennow, H. Zetterberg, P. Nellgård, B. Nellgård Tags: Original Article Source Type: research

Medtech approvals: FDA releases August 2015 PMAs
The FDA today released its list of the pre-market approvals it granted for medical devices in August 2015: Summary of PMA Originals & Supplements Approved Originals: 2 Supplements: 70 Summary of PMA Originals Under Review Total Under Review: 57 Total Active: 28 Total On Hold: 29 Summary of PMA Supplements Under Review Total Under Review: 569 Total Active: 422 Total On Hold: 147 Summary of All PMA Submissions Originals: 5 Supplements: 90 Summary of PMA Supplement PMA Approval/Denial Decision Times Number of Approvals: 70 Number of Denials: 0 Average Days Fr Receipt to Decision (Total Time): 229.0 FDA Time: 130...
Source: Mass Device - October 23, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Food & Drug Administration (FDA) Pre-Market Approval (PMA) Regulatory/Compliance Source Type: news

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