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Stroke in HIV-infected African Americans: a retrospective cohort study
Abstract The risk of having a first stroke is nearly twice as high among African Americans compared to Caucasians. HIV/AIDS is an independent risk factor for stroke. Our study aimed to report the risk factors and short-term clinical outcomes of African Americans with HIV infection and new-onset stroke admitted at the Johns Hopkins Hospitals (2000–2012). Multivariate linear regression was used to examine the association between potential predictors and odds of an unfavorable outcome, defined as a higher modified Rankin Scale (mRS) score on hospital discharge. African Americans comprised 105/125 (84 %) of HIV-inf...
Source: Journal of NeuroVirology - July 9, 2015 Category: Neurology Source Type: research

What's hot that the other lot got
Fibrinolysis for patients with intermediate-risk PE The use of fibrinolysis for normotensive patients with an intermediate risk of death after acute pulmonary embolism (PE) remains a controversial topic. The PIETHO trial (N Engl J Med 2014;370:1402–11) was a multicentre, double-blind trial, in which 1006 patients with acute PE and evidence of right ventricular dysfunction on echocardiography or CT, as well as positive cardiac troponin test, were randomly assigned to initial treatment with tenecteplase plus heparin, or placebo plus heparin. The primary outcome of death or haemodynamic compromise within 7 days of rando...
Source: Thorax - May 14, 2014 Category: Respiratory Medicine Authors: Rolin, S. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: infectious diseases, HIV/AIDS, Inflammation, Venous thromboembolism, Pulmonary embolism, Radiology (diagnostics) Chest clinic Source Type: research

Rehabilitation Improves Behavioral Recovery and Lessens Cell Death Without Affecting Iron, Ferritin, Transferrin, or Inflammation After Intracerebral Hemorrhage in Rats
Conclusions. Rehabilitation is an effective behavioral and neuroprotective strategy for ICH. Neither effect appears to stem from influencing iron toxicity or inflammation. Thus, additional work must identify underlying mechanisms to help further therapeutic gains.
Source: Neurorehabilitation and Neural Repair - April 14, 2014 Category: Neurology Authors: Caliaperumal, J., Colbourne, F. Tags: Basic Research Article Source Type: research

Stroke in Children with Human Immunodeficiency Virus in Botswana: A Report of Six Cases (P4.303)
CONCLUSIONS: The risk of stroke appears to be increased in children with HIV, though further controlled studies are necessary to further investigate this. Etiologies for stroke in children with HIV includes HIV vasculopathy, HIV cardiomyopathy, and opportunistic infections. Evaluation should include head imaging with vascular imaging, MRI with MRA if possible, and CT. The utility of lumbar puncture and hypercoaguability workup in this population needs to be investigated further. Given the difficulties of monitoring anticoagulation in this setting, low dose aspirin is a reasonable first line treatment.Disclosure: Dr. Khuran...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Khurana, E., Bearden, D. Tags: NeuroAIDS Source Type: research

Intraoperative Neurophysiologic Monitoring of Surgical and Endovascular Treatment of Pediatric Arteriovenous Malformations (S55.002)
CONCLUSIONS:Persistent IONM changes had a strong correlation with new post-operative deficits. Transient IONM changes, including those resolving after alterations in surgical management or pre-embolization methohexital testing, had a much lower risk of new deficits. Therefore, IONM can be a useful tool in pediatric AVM cases, not only in predicting neurological compromise, but also in identifying when to alter management.Study Supported by:N/ADisclosure: Dr. Nguyen has nothing to disclose. Dr. Avila has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Cho has nothing to disclose. Dr. Le has nothing to disclose. Dr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Nguyen, V., Avila, S., Lee, L., Cho, S., Le, S., Lopez, J. Tags: Pediatric Stroke and Stroke in the Young Source Type: research

Risk of Spontaneous Intracranial Hemorrhage in HIV-infected Individuals: A Population-based Cohort Study
Background: We studied the association between HIV infection, antiretroviral medications, and the risk of spontaneous intracranial hemorrhage.Methods: We performed a cohort and nested case control study in an administrative database. We selected all HIV-positive individuals presenting between 1985 and 2007. Each HIV-positive subject was matched with 4 HIV-negative individuals. We used a Poisson regression model to calculate rates of intracranial hemorrhage according to HIV status. We conducted a case -control study nested within the cohort of HIV-positive individuals to look at the effect of antiretroviral medications. Odd...
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2012 Category: Neurology Authors: Madeleine Durand, Odile Sheehy, Jean-Guy Baril, Jacques LeLorier, Cécile L. Tremblay Tags: Original Articles Source Type: research

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