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Safety and efficacy of intensive systolic blood pressure lowering after successful endovascular therapy: a post hoc analysis of the BP TARGET trial
Conclusion The effect of SBP lowering treatment was not modified by age, location of occlusion history of hypertension, intravenous thrombolysis, and admission SBP. Diabetes modified the effect of intensive SBP lowering treatment, and there was a trend towards benefit from intensive SBP treatment in diabetic patients. This finding is hypothesis generating and requires further validation.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Anadani, M., Maier, B., Escalard, S., Labreuche, J., de Havenon, A., Sabben, C., Lapergue, B., Mistry, E. A., Gory, B., Spiotta, A. M., Richard, S., Sibon, I., Desilles, J.-P., Blanc, R., Piotin, M., Mazighi, M., of behalf the BP TARGET study group, Mazig Tags: Ischemic stroke Source Type: research

O15/151 Impact of post-thrombectomy isolated subarachnoid hemorrhage and other types of intracranial hemorrhage on neurological outcomes in patients with anterior circulation ischemic stroke - reperfusion grade determines
ConclusionPost-thrombectomy i-SAH is an important complication as it might aggravate patient’s neurological impairment, particularly in case of incomplete reperfusion.Disclosure of InterestNothing to disclose.
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Landeghem, N. v., Ziegenfuss, C., Demircioglu, A., Dammann, P., Jabbarli, R., Haubold, J., Forsting, M., Wanke, I., Köhrmann, M., Frank, B., Deuschl, C., Li, Y. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

P164/236 Antithrombotic regimen in emergent carotid stenting for acute ischemic stroke due to tandem lesion: a meta-analysis of aggregate data
ConclusionsIn AIS due to tandem occlusion, the periprocedural antithrombotic regimen of eCAS seems to have a marginal effect on good functional outcome. Overall, high intensity antithrombotic therapy may provide a marginal benefit on good functional outcome and carotid stent patency without a significant increase in risk of sICH.Disclosure of InterestNothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Diana, F., Abdalkader, M., Behme, D., Li, W., Maurer, C. J., Pop, R., Hwang, Y.-H., Bartolini, B., Ros, V. D., Bracco, S., Cirillo, L., Marnat, G., Katsanos, A., Kaesmacher, J., Fischer, U., Sousa, D. A. d., Peschillo, S., Zini, A., Tomasello, A., Ribo, M Tags: 2.3 ISCHEMIC - Treatment Source Type: research

P170/281 Endovascular thrombectomy with or without thrombolysis bridging in patients with acute ischemic stroke: a systematic review and meta-analysis of randomized trials
ConclusionLow-certainty evidence shows a small possible decrease in functional independence, low-certainty evidence shows a small possible decrease in mortality, and moderate-certainty evidence that there is probably a decrease in sICH for patients with EVT alone compared to EVT plus IVT.Disclosure of InterestThe authors have nothing to disclose.
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Morsi, R. Z., Zhang, Y., Penagos, J. C., Desai, H., Tannous, E., Kothari, S., Khamis, A., Darzi, A. J., Tarabichi, A., Bastin, R., Hneiny, L., Thind, S., Coleman, E., Brorson, J. R., Mendelson, S., Mansour, A., Prabhakaran, S., Kass-Hout, T. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

E-028 mechanical thrombectomy for acute ischemic strokes in the pediatric population: review of the literature and proposed treatment algorithm
ConclusionAlthough mechanical thrombectomy for acute ischemic stroke in the pediatric population appears to have a low complication rate and a good clinical outcome, the sample size is too small to make any definitive conclusion.The initial evidence suggests benefits (average most current mRS 0.95), however, this warrants further study in a randomized controlled trial or at minimum within a registry in the context of a formalized IRB.LimitationsGiven the retrospective nature of this meta-analysis, the major limitations are sample size, which is inherent to the field of pediatric stroke, and reporting bias.DisclosuresS. Sat...
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Satti, S., Sivapatham, T., Chen, J. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

E-230 NIHSS surrogates as a predictor of 90-day functional outcome after mechanical thrombectomy for M2 middle cerebral artery occlusions
ConclusionCompared to proximal anterior circulation LVO stroke, M2 MCA occlusion strokes presented lower baseline NIHSS while yielding similar NIHSS improvement ranges with MT. NIHSS 24h after MT for M2 MCA occlusion stroke appears to be a similarly strong predictor of a functional outcome as it has been described for proximal anterior circulation LVO strokes.Disclosures M. Collins: None. G. Weiner: None. O. Goren: None. S. Dalal: None. I. Melamed: None. C. Schirmer: None. P. Hendrix: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Collins, M., Weiner, G., Goren, O., Dalal, S., Melamed, I., Schirmer, C., Hendrix, P. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

E-197 Use of balloon-mounted stents and drug eluting stents in intracranial atherosclerotic disease: single center experience
ConclusionDES appears effective and relatively safe with good long-term outcomes in treating intracranial atherosclerosis and secondary stroke prevention and is associated with lower delayed in-stent stenosis on follow up imaging compared to BMS and Wingspan stents. Use of DES for symptomatic ICAD in acute and non-emergent settings warrants further investigation.Balloon mounted stent, drug eluting stent, Wingspan, intracranial atherosclerotic disease, outcomes.Disclosures N. Turan: None. A. Malek: 2; C; CereVasc Inc.. 4; C; CereVasc Inc.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Turan, N., Malek, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-219 Direct vs indirect revascularization for moyamoya: a large multicenter study
ConclusionSince both modalities showed comparable rates of overall total strokes, both modalities of revascularization can be performed depending on the patient’s risk assessment.Abstract E-219 Table 1Direct Indirect Effect variable Value (95% confidence interval) P-value Primary Outcome Symptomatic stroke, n (%) 23/198 (11.6) 19/198 (9.6) Odds ratio 1.238 (0.651 - 2.354) 0.514 Secondary Outcomes Symptomatic ischemic stroke, n (%) 23/198 (11.6) 16/198 (8.1) Odds ratio 1.495 (0.764 - 2.924) 0.240 Symptomatic hemorrhagic stroke, n (%) 0/198 (0) 3/198 (1.5) –– –– 0.248 Peri-operative stroke,...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: El Naamani, K., Chen, C., Jabre, R., Saad, H., Grissberg, J., Dmytriw, A., Patel, A., Khorasanizadeh, M., Ogilvy, C., Thomas, A., Monteiro, A., Siddiqui, A., Cortez, G., Hanel, R., Porto, G., Spiotta, A., Piscopo, A., Hasan, D., Ghorbani, M., Weinberg, J. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-073 safety and efficacy of flow reversal in carotid angioplasty and stenting using mo. ma device
ConclusionFlow reversal using MO. MA device is a safe and effective tool in preventing distal embolization during carotid stenting.DisclosuresR. Bo: None. A. Tiwari: None. K. Arcot: None. H. Dababneh: None. J. Farkas: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Bo, R., Tiwari, A., Arcot, K., Dababneh, H., Farkas, J. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

E-140 Single center case studies comprising of early carotid stenting in patients who present with ischemic strokes
ConclusionEarly carotid stenting should be considered, when waiting 4-6 weeks might not be a feasible option due to high risk of recurrent stroke. The rate of complications is lower than what has been published in case reports and metanalyses in the literature, likely due to improved periprocedural management of platelet activity and blood pressure. Our data suggests that early carotid stenting is feasible and should be considered an option in selected cases. Larger data sets will need to be analyzed to get a clear idea of the overall complication rate.ReferencesDen Hartog, A. G., et al. Delay to carotid endarterectomy in ...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Bhatt, S., Colasurdo, M., Raghuram, K. Tags: Electronic poster abstracts Source Type: research

P152/178 Safety and efficiency of bridging i.v. thrombolysis in M2 occlusions: a propensity-score-matched registry cohort study
ConclusionIn M2-occlusions, MT+IVT was not associated with increased risk of sICH. Patients receiving MT+IVT had lower 90d-mRS and a lower increase in mRS pre-stroke to 90d. However, probability of functional independence and rates of successful recanalization were similar compared to matched controls.Disclosure of InterestHK has financial interest in Eppdata GmbH.GT received fees as consultant and lecturer from Acandis, Alexion, Amarin, Boehringer Ingelheim, Bayer, BMS/Pfizer, Daiichii Sankyo and Portola. He serves in the board of the TEA Stroke Study and of ESO.JF is consultant for Cerenovus, Medtronic, Microvention, Pen...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Kniep, H., Meyer, L., Broocks, G., Bechstein, M., Faizy, T., Winkelmeier, L., Brekenfeld, C., Flottmann, F., Paula Hanning, U. M., Thomalla, G., Fiehler, J., Gellissen, S. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

P-006 The use of iv tpa beyond 6 hours from last known normal: data from the real world
Conclusions The Trevo Retriever Registry represents the first look at real world data with stent retriever use in the era of clinical trials showing the overwhelming benefit of stent retrievers to treat large vessel occlusive acute stroke. This data represents real world use of the Trevo Retriever including those who received IV tPA beyond 4.5 hours from initial stroke symptoms and adds to the data from recent trials with restricted eligibility criteria. Disclosures H. Hedayat: None. M. Binning: None. E. Veznedaroglu: None. R. Budzik: None. J. English: None. B. Baxter: None. B. Bartolini: None. D. Liebeskind: None. A. Kr...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Hedayat, H., Binning, M., Veznedaroglu, E., Budzik, R., English, J., Baxter, B., Bartolini, B., Liebeskind, D., Krajina, A., Gupta, R., Nogueira, R. Tags: Oral Poster Abstracts Source Type: research

E-019 tcar
ConclusionsOur analysis of a single-center cohort demonstrates that TCAR is a safe and effective treatment for symptomatic carotid stenosis, with a low perioperative stroke risk. The present study’s findings concur with the combined adverse outcome rate of 3.5% reported in the ROADSTER trial.Disclosures A. Bajaj: None. S. Monje: None. C. Ayala: None. J. Poggi: None. E. Shaaya: None. J. Feler: None. K. Moldovan: None. C. Doberstein: None. R. McTaggart: None. R. Torabi: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Bajaj, A., Monje, S., Ayala, C., Poggi, J., Shaaya, E., Feler, J., Moldovan, K., Doberstein, C., McTaggart, R., Torabi, R. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

E-124 Timing surgery and hemorrhagic complications in endocarditis with concomitant cerebral complications
ConclusionsPatients with radiographic evidence of ischemic stroke from septic emboli can safely undergo valvular surgery for IE without increased risk of symptomatic hemorrhage. We advocate for baseline CTA screening to evaluate for IIA in patients who present with a primary diagnosis of IE and propose a management algorithm.Disclosures B. Lucke-Wold: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lucke-Wold, B. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

E-138 Intracerebral hemorrhage in patients transferred for mechanical thrombectomy
ConclusionsIn a large series of stroke patients being specifically transferred for mechanical thrombectomy, the rate of ICH on arrival to the thrombectomy hospital was 1.2%. In less than 50% of those cases the decision to forgo intervention was related to the ICH finding. The results of our study adds to the concerns that repeat imaging delays treatment by demonstrating that the incidence of ICH is low, which may warrant reconsideration of current stroke workflows for large vessel occlusion transfers.Disclosures Y. Radaideh: None. K. Joshi: None. M. Chen: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Radaideh, Y., Joshi, K., Chen, M. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

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