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Low Estimated Glomerular Filtration Rate is Associated with High Recurrence Rate and Poor Prognosis of Hemorrhage Stroke.
This study investigated whether a low estimated glomerular filtration rate (eGFR) leads to a higher risk of stroke recurrence and a poor prognosis in hemorrhagic stroke patients. A total of 2000 stroke patients were recruited during 2000-2001 and prospectively followed up for a median of 4.5 years. The independent association of a low eGFR with stroke recurrence and poor prognosis was evaluated using Kaplan-Meier analysis and Cox regression models. Among the hemorrhagic stroke patients, the incidence rate of a low eGFR for the compound endpoints (stroke recurrence, myocardial infarction, and all-cause mortality) was greate...
Source: Current Neurovascular Research - March 4, 2015 Category: Neurology Authors: Kai S, Jiaoyan QU, Weihua S, Yinhui Z, Channa Z, Li S, Yan S, Rutai H, Jingzhou C Tags: Curr Neurovasc Res Source Type: research

Gastrointestinal Hemorrhage Is Associated with Mortality after Acute Ischemic Stroke.
CONCLUSION: AF, oral anticoagulant use, brain herniation and male sex increase GI hemorrhage risk, while hyperlipidemia reduces risk. GI hemorrhage itself increases risk for mortality of acute ischemic stroke. The interaction between GI hemorrhage and brain herniation increased the risk for the mortality after acute ischemic stroke. PMID: 30977448 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - April 11, 2019 Category: Neurology Authors: Zhou Y, Xu W, Wang W, Yao S, Xiao B, Wang Y, Chen B Tags: Curr Neurovasc Res Source Type: research

Reduction in estimated glomerular filtration rate (eGFR) results in an increased risk of spontaneous hemorrhagic transformation in patients with large-artery atherosclerosis stroke.
In conclusion, reduced eGFR was significantly associated with increased risk of spontaneous HT in all ischemic stroke patients, and in large artery atherosclerosis, not in cardio-embolism stroke. Reduced eGFR did not increase the risk of symptomatic HT. PMID: 26503023 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - October 27, 2015 Category: Neurology Authors: Liu B, Wang D, Hao Z, Li D, Zhang J, Liu J, Liu M Tags: Curr Neurovasc Res Source Type: research

Young stroke patients treated with intravenous thrombolysis have a more favorable outcome and mortality compared with older patients.
CONCLUSIONS: Our analysis indicated that young stroke patients treated with IVT had a more favorable outcome without an increased risk of sICH and mortality compared with older patients. We conclude that IVT is safe and at least as beneficial for Chinese young adults with acute ischemic stroke compared with older patients. PMID: 28356003 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - March 27, 2017 Category: Neurology Authors: Shi J, Cao Y, You S, Huang Z, Zhang X, Liu H, Liu CF Tags: Curr Neurovasc Res Source Type: research

Increased Neutrophil-to-lymphocyte Ratios are Associated with Greater Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke.
CONCLUSIONS: Higher level of NLR is associated with greater risk of hemorrhagic transformation in patients with acute ischemic stroke, especially in cardio-embolic stroke. Moreover, the results suggest that therapeutic interventions that may increase the risk of bleeding should be undertaken carefully in the management of AIS patients with higher NLR. PMID: 30514190 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - December 4, 2018 Category: Neurology Authors: Song Q, Li Y, Wang Y, Wei C, Liu J, Liu M Tags: Curr Neurovasc Res Source Type: research

Low Baseline Urine Creatinine Excretion Rate Predicts Poor Outcomes among Critically Ill Acute Stroke Patients.
In conclusion, low baseline CER, a marker of muscle mass, was independently associated with poor 6-month outcome among critically ill acute stroke patients. We speculate that preservation of muscle mass through exercise or protein-energy supplement might be helpful for improving prognosis in severe stroke patients. PMID: 25557376 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - January 2, 2015 Category: Neurology Authors: Hsu C, Wu Y, Cheng C, Lee J, Huang Y, Lee M, Wu C, Hsu H, Lin Y, Huang Y, Yang H, Yang J, Lee M, Ovbiagele B Tags: Curr Neurovasc Res Source Type: research

What is the current role for vitamin D and the risk of stroke ?
Abstract Increasing evidence support the relationship between vitamin D and stroke. Vitamin D have now been proposed as a prognostic biomarker for also functional outcome in stroke patients. A revision of the data suggests that low vitamin D is associated more with ischemic than with haemorrhagic stroke, even if the role of optimal vitamin D levels for vascular wall is still unclear. Vitamin D deficiency induces with different mechanisms an alteration of vascular wall. However, to date, the research supporting the effectiveness of vitamin D supplementation in stroke and in post-stroke recovery is still inadequate ...
Source: Current Neurovascular Research - April 11, 2019 Category: Neurology Authors: Siniscalchi A, Lochner P, Anticoli S, Chirchiglia D, De Sarro G, Gallelli L Tags: Curr Neurovasc Res Source Type: research

Cerebral Microbleeds Do Not Predict Hemorrhagic Transformation in Acute Ischemic Stroke Patients with Atrial Fibrillation and/or Rheumatic Heart Disease.
Conclusion The present study suggests that CMBs do not predict the presence of hemorrhagic transformation in acute ischemic stroke patients with AF and/or RHD. The results were not affected by anticoagulant or antiplatelet agents used in acute stage of ischemic stroke. PMID: 28294063 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - March 12, 2017 Category: Neurology Authors: Liu J, Wang D, Li J, Lin J, Xiong Y, Liu B, Wei C, Wu B, Ma Z, Zhang S, Liu M Tags: Curr Neurovasc Res Source Type: research

Association of Non-Traditional Lipid Parameters with Hemorrhagic Transformation and Clinical Outcome After Thrombolysis in Ischemic Stroke Patients.
CONCLUSION: Low TC/HDL-C, TG/HDL-C, and LDL/HDL-C, but not non-HDL-C, were associated with an increased risk of HT after thrombolysis. In addition, low non-HDL-C, TC/HDL-C, TG/HDL-C, and LDL/HDL-C were associated with an increased risk of poor outcome in ischemic stroke patients with intravenous thrombolysis. PMID: 33397260 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - January 1, 2021 Category: Neurology Authors: Luo Y, Chen J, Yan XL, Jin H, Sun X, Guo ZN, Yang Y Tags: Curr Neurovasc Res Source Type: research

Cocaine Dependence and Stroke: Pathogenesis and Management.
Abstract Cocaine abuse remains a devastating medical problem for our society. Current concepts suggest that both hemorrhagic and ischemic stroke, particularly in young people, can result as a consequence of cocaine exposure. We provide an analysis of mechanisms of injury and a discussion of the pharmacological management of stroke following cocaine use. Preclinical research suggests that the cause of cocaine-mediated stroke is multifactorial and involves vasospasm, changes in cerebral vasculature, and platelet aggregation. We suggest that drugs able to induce vasospastic, thrombogenic, or neurotoxic effects of coc...
Source: Current Neurovascular Research - March 4, 2015 Category: Neurology Authors: Siniscalchi A, Bonci A, Mercuri NB, Siena A, Sarro G, Malferrari G, Diana M, Gallelli L Tags: Curr Neurovasc Res Source Type: research

Dabigatran etexilate reduces thrombin-induced inflammation and thrombus formation in experimental ischemic stroke.
Abstract Dabigatran etexilate (DE), a direct-acting, oral inhibitor of thrombin, significantly reduces the risk of stroke compared with traditional anticoagulants, without increasing the risk of major bleeding. However, studies on the fate of cerebral tissue after ischemic stroke in patients receiving DE are sparse and the role of dabigatran-mediated reduction of thrombin in this context has not yet been investigated. Here, we investigated whether pretreatment with DE reduces thrombin-mediated pro-inflammatory mechanisms and leakage of the blood-brain barrier (BBB) following ischemic stroke in rats. Male Wistar ra...
Source: Current Neurovascular Research - May 16, 2016 Category: Neurology Authors: Dittmeiera M, Wassmutha K, Schuhmanna MK, Krafta P, Kleinschnitz C, Fluri F Tags: Curr Neurovasc Res Source Type: research

Safety and Efficiency of Low Dose Intra-arterial Tirofiban in Mechanical Thrombectomy During Acute Ischemic Stroke.
CONCLUSION: Intra-arterial tirofiban may be safe in mechanical thrombectomy of acute ischemic stroke to facilitate the reperfusion of distal vessel, but has no beneficial effect on prognosis. PMID: 29875001 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - June 4, 2018 Category: Neurology Authors: Yu T, Lin Y, Jin A, Zhang P, Zhou X, Fang M, Liu X Tags: Curr Neurovasc Res Source Type: research

Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke Patients receiving Thrombectomy: Standard or Low Dose Therapy?
Conclusions - Compared to standard dose treatment, low dose rtPA may have similar clinical efficacy and safety outcomes in AIS patients receiving bridging therapy. PMID: 30014803 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - July 16, 2018 Category: Neurology Authors: Lin CH, Liu CH, Wang AY, Wu YM, Chen CC, Tsai YH, Chang TY, Huang KL, Wu HC, Lee TH, Chang YJ, Lin CM, Cheng CK, Chang CH Tags: Curr Neurovasc Res Source Type: research

Vulnerable Carotid Plaque is Associated with An Increased Risk of Intracerebral Hemorrhage in Individuals at High Risk of Stroke: A Chinese Population-based Cohort Study
CONCLUSION: In Chinese individuals at high risk of stroke, vulnerable carotid artery plaques are associated with an increased risk of intracerebral hemorrhage independent of classical vascular risk factors, especially in female individuals.PMID:37438901 | DOI:10.2174/1567202620666230712114927
Source: Current Neurovascular Research - July 13, 2023 Category: Neurology Authors: Jie Li Ping Zhang Hong Chen Ting Qing Yanfen Wang Ju Zhou Xingyang Yi Chun Wang Source Type: research

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