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Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

The Study of Risk Factors and The Predict Model of Cerebral Microbleeds
CONCLUSIONS: Hypertension, alcohol use, hemorrhagic stroke history and WMH were added into the model- HPSAD3, and there was a higher possibility of patients with CMBs ≥10 when the score of HPSAD3 ≥4.PMID:37431898 | DOI:10.2174/1567202620666230710160809
Source: Current Neurovascular Research - July 11, 2023 Category: Neurology Authors: Tao Lv Changqing Li Source Type: research

Efficacy and safety of alteplase on treatment of acute single small subcortical infarction
CONCLUSION: Patients with SSSI in the anterior circulation are more likely to achieve 3 months favorable outcomes than those who were treated with standard medical care, however treatment with alteplase may not prevent occurrence of END.PMID:36043775 | DOI:10.2174/1567202619666220829111211
Source: Current Neurovascular Research - August 31, 2022 Category: Neurology Authors: Kilanga Marcelinus Hongbing Liu Ke Zhang Ce Zong Hongxun Yang Yuan Gao Bo Song Yuming Xu Source Type: research

Increased serum total bile acids can be associated with a small hematoma volume and decreased clinical severity during acute intracerebral hemorrhage.
CONCLUSIONS: Higher admission TBA was associated with smaller hematoma volume and decreased clinical severity, but not three month outcomes in patients with acute ICH. PMID: 29766806 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - May 15, 2018 Category: Neurology Authors: Wang K, Zhang Y, Zhong C, Xu J, Zhang Y, Shi J, Xiao G, Zhang X, Liu H, Huang Z, Liu CF, You S, Cao Y Tags: Curr Neurovasc Res Source Type: research

Timing of Tracheostomy in Patients with Intracerebral Haemorrhage: A Propensity-Matched Analysis
CONCLUSION: We recommend ET for high-risk patients with ICH. Although ET cannot reduce in-hospital mortality or improve patient prognosis, it may help reduce hospital costs and ICU LOS as well as the use of antibiotics, sedatives and muscle relaxants.PMID:36125838 | DOI:10.2174/1567202619666220920122935
Source: Current Neurovascular Research - September 20, 2022 Category: Neurology Authors: Bo Luo Hua-Xuan Chen Xu-Dong Song Lin Wang Xue-Yun Deng Xiao-Ping Tang Source Type: research

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