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Does Weekends Effect Exist in Asia? Analysis of Endovascular Thrombectomy for Acute Ischemic Stroke in A Medical Center
Conclusions This study revealed nonworking-hour effects truly exist in patients who received EST. Although delays in door-to-groin puncture times were noticed during nonworking hours, significant differences in neurological functions and mortality were not observed between working and nonworking hours. Nevertheless, methods to improve the process during nonworking hours should be explored in the future.PMID:35894472 | DOI:10.2174/1567202619666220727094020
Source: Current Neurovascular Research - July 27, 2022 Category: Neurology Authors: Chia-Wei Lin Hung-Yu Huang Jeng-Hung Guo Wei-Laing Chen Hong-Mo Shih Hsueh-Ting Chu Charles C N Wang Tai Hsu Source Type: research

Pathogenic mechanisms of a stroke-like attack elicited by epidural steroid injection therapy.
This article dissects the potential pathogenic mechanisms at a neurovascular unit. Noticeably, a schematic provides an explanation of how emboli formed by particulate steroids elicit either hemorrhagic or ischemic lesion. In addition, development of a rat model with intravertebral artery steroid injection is a proposal to address the unmet need in evaluating steroids and vascular injury in ESI. PMID: 32294038 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - April 14, 2020 Category: Neurology Authors: He Z Tags: Curr Neurovasc Res Source Type: research

Early Ischemic Blood Brain Barrier Damage: A Potential Indicator for Hemorrhagic Transformation Following Tissue Plasminogen Activator (tPA) Thrombolysis?
Abstract Tissue plasminogen activator (tPA) thrombolysis, remains the only United States Food and Drug Administration(FDA) approvedtreatmentfor acute ischemia stroke. However, the use of tPA has been profoundly constraineddue to its narrow therapeutic time window and the increased risk of potentially deadly hemorrhagic complications. TPA-associated hemorrhagic transformation (HT) often occurs as a result of catastrophic failure of theblood brain barrier (BBB), wherein the affected cerebral capillaries can no longer hold blood constituents.Due to its direct contribution to edema and HT, reperfusion-associated BBB d...
Source: Current Neurovascular Research - May 30, 2014 Category: Neurology Authors: Jin X, Liu J, Liu W Tags: Curr Neurovasc Res Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

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