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Total 5383 results found since Jan 2013.

Catapol reduced the cognitive and mood dysfunctions in post-stroke depression mice via promoting PI3K-mediated adult neurogenesis
In conclusion, catapol could perform as the effective drug to treat PSD via the PI3K mediated adult hippocampal neurogenesis.PMID:37647020 | DOI:10.18632/aging.204979
Source: Aging - August 30, 2023 Category: Biomedical Science Authors: Bo Li Xin Zhou Lu Zhen Weiwei Zhang Jian Lu Jie Zhou Huoquan Tang Huangsuo Wang Source Type: research

Influence of Family-centered Health Intervention on Perioperative Mental Health of Patients Receiving Coronary Interventional Therapy
CONCLUSIONS: Family-centered health intervention benefited perioperative patients receiving coronary intervention therapy. It improved patients' mood and sleep quality and demonstrated positive application value.PMID:37632967
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Xianjie Hao Dongjing Wang Xiuping Xiao Source Type: research

Too Little Sleep Destroys DNA?
I talk to my patients about the danger of not sleeping all the time. Unfortunately, it’s a common problem that affects 75 million Americans. People who don’t sleep, or sleep poorly, have up to 400% more accidents that those who get a good night’s rest. Not getting enough sleep also increases your risk of developing chronic diseases. Studies, including a large meta-analysis of 470,000 adults, found that those who slept less than six hours developed a:1,2,3,4,5 48% increase in the incidence of coronary heart disease 30% increased risk of dementia 15% increase in the incidence of stroke 50% cancer risk 17% higher risk ...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Source Type: news

The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases
Neuropharmacology. 2023 Aug 22:109690. doi: 10.1016/j.neuropharm.2023.109690. Online ahead of print.ABSTRACTAt present, a large number of relevant studies have suggested that the changes in gut microbiota are related to the course of nervous system diseases, and the microbiota-gut-brain axis is necessary for the proper functioning of the nervous system. Indole and its derivatives, as the products of the gut microbiota metabolism of tryptophan, can be used as ligands to regulate inflammation and autoimmune response in vivo. In recent years, some studies have found that the levels of indole and its derivatives differ signifi...
Source: Neuropharmacology - August 24, 2023 Category: Drugs & Pharmacology Authors: Yi Zhou Yue Chen Hui He Meichang Peng Meiqin Zeng Haitao Sun Source Type: research

Efficacy of scalp acupuncture combined with conventional therapy in the intervention of post-stroke depression: A systematic review and meta-analysis
CONCLUSION: While the effectiveness of SA combined with CT in treating PSD still requires further validation through rigorous randomized double-blind trials, this study provides a comprehensive collection of studies that meet the criteria for SA combined with CT in PSD treatment. It objectively and systematically evaluated the impact of SA combined with CT on PSD. Consequently, the findings of this study hold certain clinical significance.PMID:37619716 | DOI:10.1016/j.ctim.2023.102975
Source: Complementary Therapies in Medicine - August 24, 2023 Category: Complementary Medicine Authors: Dayuan Zhong Hui Cheng Zhenghua Pan Xueming Ou Pingwen Liu Xiangbo Kong Deliang Liu Jiaqi Chen Jiarong Li Source Type: research

Efficacy of Scalp Acupuncture Combined with Conventional Therapy in the Intervention of Post-stroke Depression: a Systematic Review and Meta-analysis
CONCLUSION: While the effectiveness of SA combined with CT in treating PSD still requires further validation through rigorous randomized double-blind trials, this study provides a comprehensive collection of studies that meet the criteria for SA combined with CT in PSD treatment. It objectively and systematically evaluated the impact of SA combined with CT on PSD. Consequently, the findings of this study hold certain clinical significance.PMID:37619716 | DOI:10.1016/j.ctim.2023.102975
Source: Complementary Therapies in Medicine - August 24, 2023 Category: Complementary Medicine Authors: Dayuan Zhong Hui Cheng Zhenghua Pan Xueming Ou Pingwen Liu Xiangbo Kong Deliang Liu Jiaqi Chen Jiarong Li Source Type: research

The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases
Neuropharmacology. 2023 Aug 22:109690. doi: 10.1016/j.neuropharm.2023.109690. Online ahead of print.ABSTRACTAt present, a large number of relevant studies have suggested that the changes in gut microbiota are related to the course of nervous system diseases, and the microbiota-gut-brain axis is necessary for the proper functioning of the nervous system. Indole and its derivatives, as the products of the gut microbiota metabolism of tryptophan, can be used as ligands to regulate inflammation and autoimmune response in vivo. In recent years, some studies have found that the levels of indole and its derivatives differ signifi...
Source: Neuropharmacology - August 24, 2023 Category: Drugs & Pharmacology Authors: Yi Zhou Yue Chen Hui He Meichang Peng Meiqin Zeng Haitao Sun Source Type: research

Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts
Background Current dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations. Objective We aimed to develop and validate a novel dementia risk score for a midlife UK population, using two cohorts: the UK Biobank, and UK Whitehall II study. Methods We divided the UK Biobank cohort into a training (n=176 611, 80%) and test sample (n=44 151, 20%) and used the Whitehall II cohort (n=2934) for external validation. We used the Cox LASSO regression to select the strongest predictors of incident dementia from 28 candidate predictors and then dev...
Source: Evidence-Based Mental Health - August 21, 2023 Category: Psychiatry & Psychology Authors: Anatürk, M., Patel, R., Ebmeier, K. P., Georgiopoulos, G., Newby, D., Topiwala, A., de Lange, A.-M. G., Cole, J. H., Jansen, M. G., Singh-Manoux, A., Kivimäki, M., Suri, S. Tags: Open access, Press releases Old age psychiatry Source Type: research

Risk factors for dementia in older intensive care unit (ICU) survivors
DISCUSSION: Future studies will need to examine whether interventions targeting post-ICU stroke and depression can lower dementia incidence in ICU survivors.HIGHLIGHTS: Risk factors for post-intensive care unit (ICU) dementia were distinct from those of Alzheimer's disease. Cardiovascular risk factors were not associated with dementia in older ICU survivors. Post-ICU stroke was associated with a higher risk of dementia in older ICU survivors. Post-ICU depression was associated with a higher risk of dementia in older ICU survivors.PMID:37589315 | DOI:10.1002/alz.13423
Source: The Journal of Alzheimers Association - August 17, 2023 Category: Psychiatry Authors: Sophia Wang Anthony J Perkins Rosalyn Chi Brandon A Yates Sikandar H Khan Sujuan Gao Malaz Boustani Babar A Khan Source Type: research

Lesion location and serum levels of homocysteine are associated with early ‐onset post‐stroke depression in acute ischemic stroke
ConclusionsOur study indicated that higher NIHSS score, elevated serum levels of HCY, and multiple-site lesions may be independent risk factors of early-onset PSD. The combination of HCY, NIHSS scores, multiple-site lesions, and lesion location may provide greater predictive value than HCY alone for early-onset PSD. Early intervention for elevated serum levels of HCY may be a potential target for the intervention and prevention of PSD.
Source: Brain and Behavior - August 17, 2023 Category: Neurology Authors: Hongxu Zhou, Chenlong Wang, Wei Wang, Hongyan Li, Qun Hu, Ni Huang, Yining Huang Tags: ORIGINAL ARTICLE Source Type: research

Depressive Symptoms and Anger Expression Among Survivors After Stroke
CONCLUSIONS: Early detection and management of depression and anger will facilitate patient's compliance to the rehabilitation program in order to achieve optimal therapeutic results and ensure a better quality of life.PMID:37581799 | DOI:10.1007/978-3-031-31986-0_24
Source: Advances in Experimental Medicine and Biology - August 15, 2023 Category: Research Authors: Anastasia Papadopoulou Panagiotis Papadopoulos Eirini Grammatopoulou Anna Kavga Alexandra Koreli Alexandra Mantoudi Angeliki Stamou Georgia Gerogianni Afroditi Zartaloudi Source Type: research