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Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus
ConclusionsAZE lowers ICP directly via its ability to reduce the choroid plexus CSF secretion, irrespective of mode of drug administration.
Source: Fluids and Barriers of the CNS - June 29, 2022 Category: Neuroscience Source Type: research

A multicenter cohort study of early complications after cranioplasty: results of the German Cranial Reconstruction Registry
CONCLUSIONS: The authors have presented class II evidence-based data on surgery-related complications after CP and have identified specific preexisting risk factors. These results may provide additional guidance for optimized treatment of these patients.PMID:34920418 | DOI:10.3171/2021.9.JNS211549
Source: Journal of Neurosurgery - December 17, 2021 Category: Neurosurgery Authors: Thomas Sauvigny Henrik Giese Julius H öhne Karl Michael Schebesch Christian Henker Andreas Strauss Kerim Beseoglu Niklas von Spreckelsen J ürgen A Hampl Jan Walter Christian Ewald Aleksandrs Krigers Ondra Petr Vicki M Butenschoen Sandro M Krieg Christin Source Type: research

Comparison of static and dynamic cerebral autoregulation under anesthesia influence in a controlled animal model
by Alexander Ruesch, Deepshikha Acharya, Samantha Schmitt, Jason Yang, Matthew A. Smith, Jana M. Kainerstorfer The brain’s ability to maintain cerebral blood flow approximately constant despite cerebral perfusion pressure changes is known as cerebral autoregulation (CA) and is governed by vasoconstriction and vasodilation. Cerebral perfusion pressure is defined as the pressure gradient between arterial b lood pressure and intracranial pressure. Measuring CA is a challenging task and has created a variety of evaluation methods, which are often categorized as static and dynamic CA assessments. Because CA is quantified as ...
Source: PLoS One - January 8, 2021 Category: Biomedical Science Authors: Alexander Ruesch Source Type: research

The management of spontaneous primary intracerebral haemorrhage
Publication date: Available online 12 December 2019Source: Anaesthesia & Intensive Care MedicineAuthor(s): Christopher J. TaylorAbstractIntracerebral haemorrhage (ICH) accounts for around 10–20% of all strokes and results from a variety of disorders. ICH is more likely to result in death or major disability than ischaemic stroke or subarachnoid haemorrhage. Rapid imaging allows early diagnosis and characterization of the localization and severity of the haemorrhage. Patients with significant acute ICH should be managed in a critical care unit. Treatment entails general supportive care, control of blood pressure and intra...
Source: Anaesthesia and intensive care medicine - December 13, 2019 Category: Anesthesiology Source Type: research

Letter to the Editor: Pneumocephalus: Is the needle size significant?
Discussion. Pneumocephalus is defined by two mechanisms: a ball-valve and an inverted bottle concept.1 The ball-valve type implies positive pressure events, such as coughing or valsalva maneuvers, that prevent air escape. Tension pneumocephalus is included in this mechanism, causing a parenchymal mass effect. The inverted bottle theory includes a negative intracranial pressure gradient following cerebrospinal fluid drainage, relieved by air influx. A small pneumocephalus is usually sealed by blood clots or granulation, allowing spontaneous reabsorption and resolution.[1] Otherwise, the lateral positioning of a patient duri...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools CNS Infections Current Issue Letters to the Editor Neurologic Systems and Symptoms Neurology Stroke Traumatic Brain Injury epidural needle size Pneumocephalus spinal tap Source Type: research

Keeping up with Amanda: Life after brain surgery
In most ways, Amanda LePage is just like any other rambunctious fourth grader. She loves school, dance class, playing basketball and keeping up with her twin sister Macy and older brother Nathan. Sometimes it just takes her a little longer to do these everyday things. That’s because Amanda has been through a lot in her short nine years. Amanda was just 5 months old when she was brought by helicopter to Boston Children’s Hospital for a hemorrhage in her brain from an intracranial aneurysm, a type of vascular malformation. Despite long odds, Amanda survived two life-saving brain surgeries and a massive stroke that left ...
Source: Thrive, Children's Hospital Boston - May 22, 2017 Category: Pediatrics Authors: Ellen Greenlaw Tags: Our Patients’ Stories brain aneurysm Dr. Caroline Robson Dr. Craig McClain Dr. Edward Smith Dr. Peter Manley Hydrocephalus low-grade glioma pediatric stroke Source Type: news