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Comparative Effectiveness of Combination Therapy with Statins and Angiotensin ‐Converting Enzyme Inhibitors versus Angiotensin II Receptor Blockers in Patients with Coronary Heart Disease: A Nationwide Population‐Based Cohort Study in Korea
ConclusionA MACCE was less likely to occur in patients who received a statin ‐ARB than in those who received a statin‐ACEI. Similar trends were seen in cardiovascular mortality and the occurrence of recurrent MI but not stroke. The availability of statin‐ARB fixed‐dose combinations may have contributed to the improved outcomes in the statin‐ARB cohort by reducing p ill burden and improving medication adherence. Further research is warranted to validate our findings and to address whether a particular statin‐ARB combination is more effective than other combinations.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 6, 2018 Category: Drugs & Pharmacology Authors: Jimin Lee, Sukhyang Lee Tags: Original Research Article Source Type: research

Changes in the prevalence of statin use in Germany - findings from national health interview and examination surveys 1997-1999 and 2008-2011.
CONCLUSION: The increase in the prevalence of statin use in Germany between the two national health surveys (1997-1999 and 2008-2011) reflects the implementation of current guideline recommendations without evidence for inequalities according to gender, education, type of health insurance or region of residence. These population-based data add to information on statin prescription obtained from statutory health insurance data. Limitations of survey-based information derive from potential misclassification and selection bias as well as large time gaps between the survey periods. Further studies are needed to examine why the...
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - May 19, 2017 Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research

Racial differences in statin adherence following hospital discharge for ischemic stroke
Conclusions: Compared with white adults, black adults were more likely to be nonadherent to statins following hospitalization for ischemic stroke.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Albright, K. C., Zhao, H., Blackburn, J., Limdi, N. A., Beasley, T. M., Howard, G., Bittner, V., Howard, V. J., Muntner, P. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Effect of statin use on clinical outcomes in ischemic stroke patients with atrial fibrillation
The objective of this study was to clarify whether statin therapy can influence the prognosis in recent ischemic stroke patients with atrial fibrillation. We identified ischemic stroke patients with atrial fibrillation between 2001 and 2011 from Taiwan National Health Insurance Database. Patients not treated with statins during the first 90 days after the index stroke were matched to patients treated with statins in the first 90 days in a 2:1 ratio on the basis of age, sex, hypertension, diabetes mellitus, ischemic heart disease, heart failure, estimated National Institutes of Health Stroke Scale, use of anticoagulant, an...
Source: Medicine - February 1, 2017 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

The Jekyll and Hyde of Statins
By Drs. David Niesel and Norbert Herzog, Medical Discovery News Cholesterol-lowering drugs called statins are the most prescribed drug ever. About 30 percent of Americans are currently taking statins such as Crestor, Lipitor, Mevacor and Zocor. Overall, statins can be good thing, but as with all drugs, there are some negative effects. Statins lower cholesterol by inhibiting a protein called HMG-CoA reductase. Since high cholesterol levels are linked to heart disease, statins can reduce the risks of heart attack and stroke, two of the leading causes of death in the United States. Recent reports from the American Heart Assoc...
Source: Science - The Huffington Post - February 3, 2016 Category: Science Source Type: news

Changing Cholesterol Levels and Coronary Heart Disease Risk.
Abstract A report by Colantonio and colleagues in this issue of Circulation describes the relations between serum lipoprotein cholesterol levels and triglycerides with coronary heart disease (CHD) incidence.(1) Their analyses draw upon the experience of three American population samples of adults with 8.9 years of follow up. The first study group is the Reasons for Geographic and Racial Differences in Stroke (REGARDS, National Institutes of Health observational cohort, baseline 2003-2007), the second investigation is the Atherosclerosis Risk in Communities (ARIC, National Heart, Lung and Blood observational cohort...
Source: Circulation - December 9, 2015 Category: Cardiology Authors: Wilson PW Tags: Circulation Source Type: research

Prescription Cholesterol-lowering Medication Use in Adults Aged 40 and Over: United States, 2003-2012.
Authors: Gu Q, Paulose-Ram R, Burt VL, Kit BK Abstract KEY FINDINGS: Data from the National Health and Nutrition Examination Survey. During 2003-2012, the percentage of adults aged 40 and over using a cholesterol-lowering medication in the past 30 days increased from 20% to 28%. The use of statins increased from 18% to 26%. By 2011-2012, 93% of adults using a cholesterol-lowering medication used a statin. Cholesterol-lowering medication use increased with age, from 17% of adults aged 40-59 to 48% of adults aged 75 and over. About 71% of adults with cardiovascular disease and 54% of adults with hypercholesterolemia ...
Source: NCHS data brief - December 29, 2014 Category: American Health Tags: NCHS Data Brief Source Type: research

Could statins also protect against dementia?
Conclusion This study using a large, older age, Asian population finds an association between statin use and reduced risk of developing dementia over an average five years of follow-up. The main limitation of this study is that it can demonstrate an association, but it cannot definitely prove cause and effect. The study has adjusted for a number of measured confounders, but this may not fully account for these or other factors (such as lifestyle habits) that may be involved in the relationship.  Also, while the research has used what can be expected to be a fairly reliable research database, there is also the possibility...
Source: NHS News Feed - April 14, 2014 Category: Consumer Health News Tags: Medication Neurology Source Type: news

CHADS2 Score, Statin Therapy, and Risks of Atrial Fibrillation
This study aimed to evaluate the efficacy of statin treatment for atrial fibrillation prevention in elderly patients with hypertension, and to determine if comorbidity or CHADS2 (Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, prior Stroke or transient ischemic attack) score can predict the effectiveness of statin treatment. Methods: Patients aged ≥65 years with hypertension were identified from a National Health Insurance research database (a systemic sampling from 2000 to 2009 with a total of 1,000,000 subjects). Medical records of 27,002 patients were used in this study, in which 2400 (8....
Source: The American Journal of Medicine - January 17, 2013 Category: Journals (General) Authors: Chen-Ying Hung, Ching-Heng Lin, El-Wui Loh, Chih-Tai Ting, Tsu-Juey Wu Tags: Clinical research studies Source Type: research