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Early Results of Surgical Simultaneous Therapy for Significant Carotid Artery Stenosis and Heart Disease.
Conclusion Simultaneous coronary bypass grafting as a single procedure or in combination with valve replacement and endarterectomy of severe carotid lesions with or without patients' history of previous stroke can be performed with a calculated low surgical risk. The complication rate for neurologic and myocardial events is low compared with the hazard of a single surgical repair. The in-hospital mortality is not significantly different to isolated procedures. The concomitant appearance of coronary stenosis and carotid artery disease is reasonable due to the nature of arteriosclerosis. In our opinion these patients benef...
Source: The Thoracic and Cardiovascular Surgeon - April 5, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Irqsusi M, Vannucchi A, Beckers J, Kasseckert S, Waldhans S, Vogt S, Moosdorf RG Tags: Thorac Cardiovasc Surg Source Type: research

Substance found in red wine 'helps fight ageing'
Conclusion Resveratrol has been of interest to anti-ageing scientists for many years and researchers have previously shown it may be linked to a slowing of the decline in thinking and movement, at least in rodents. This study suggests a possible way this might happen. But the results don't tell us anything about what happens in humans. They suggest this substance may be useful for further research in humans at some point. They certainly don't provide a reason to drink gallons of red wine, in the hope of seeing an anti-ageing effect. Drinking too much alcohol is a sure-fire way to speed up deterioration of thinking skills,...
Source: NHS News Feed - March 8, 2017 Category: Consumer Health News Tags: Food/diet Lifestyle/exercise Neurology Source Type: news

Cognitive antihyperlipidemic and antioxidant activities of bitter leaf ( < em > Vernonia amygdalina < /em > ) and Scent leaf ( < em > Ocimum gratissimum < /em > )
Oxidative stress manifests an imbalance in the production and the detoxification of free radicals. Free radicals cause oxidative degradation of biomolecules like lipids, proteins, nucleic acids, and carbohydrate molecules, thereby compromising cell integrity and function and leading to health deterioration from a range of metabolic anomalies that cause diseases and ailments including cardiovascular diseases (CVD), hypertension, stroke and cancer. Both bitter leaf (VA) and Scent leaf (OG) have been medicinally useful in the cure of diseases in different cultures.The addition of scent leaf as additive in preparation of delic...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Ibukun Emmanuel Oluwafemi Source Type: research

Challenging the Great Vascular Wall: can we envision a simple yet comprehensive therapy for stroke?
Abstract Stroke is a leading cause of death in adult life, closely behind ischemic heart disease, and causes a significant and abiding socioeconomic burden. However, current therapies are not able to ensure full neurologic and/or sequelae‐free recovery to all stroke survivors. We believe treatment efficacy and patient rehabilitation could be enhanced significantly by targeting blood‐brain barrier (BBB) deregulation and inflammation‐induced barrier loss occurring after stroke. In this pathological context, bone marrow‐derived endothelial progenitor cells (EPC) enter the bloodstream towards the lesion site but their ...
Source: Journal of Tissue Engineering and Regenerative Medicine - January 31, 2017 Category: Biotechnology Authors: Marta Machado ‐Pereira, Tiago Santos, Lino Ferreira, Liliana Bernardino, Raquel Ferreira Tags: Perspective Source Type: research

Direct oral anticoagulant use in nonvalvular atrial fibrillation with valvular heart disease: a systematic review
In conclusion, subanalyses of DOAC landmark AF trials revealed that dabigatran, rivaroxaban, and apixaban may be safely used in AF patients with certain types of VHD: aortic stenosis, aortic regurgitation, and mitral regurgitation. More evidence is needed before routinely recommending these agents for patients with bioprosthetic valves or mild mitral stenosis. Patients with moderate to severe mitral stenosis or mechanical valves should continue to receive warfarin, as these patients were excluded from all landmark AF trials.
Source: Clinical Cardiology - December 21, 2016 Category: Cardiology Authors: Ryan E. Owens, Rajesh Kabra, Carrie S. Oliphant Tags: Reviews Source Type: research

Management of supraventricular arrhythmias in adults with congenital heart disease
Supraventricular arrhythmias are a frequent complication in adults with congenital heart disease (ACHD). The prevalence increases with time since surgery, complexity of the underlying defect, type of repair and older age at surgery. Arrhythmias are the most frequent reason for hospital admission and along with heart failure the leading cause of death. The arrhythmia-associated increase in morbidity and mortality makes their management a key task in patients with ACHD. Intra-atrial re-entry is the most frequent arrhythmia mechanism. Less common arrhythmia mechanisms are supraventricular tachycardias in the presence of an ac...
Source: Heart - September 26, 2016 Category: Cardiology Authors: Wasmer, K., Eckardt, L. Tags: Review articles Reviews Source Type: research

Mitochondrial Lon Protease in Human Disease and Aging: Including an etiologic classification of Lon-related diseases and disorders.
Abstract The Mitochondrial Lon protease, also called LonP1 is a product of the nuclear gene LONP1. Lon is a major regulator of mitochondrial metabolism and response to free radical damage, as well as an essential factor for the maintenance and repair of mitochondrial DNA. Lon is an ATP-stimulated protease that cycles between being bound (at the inner surface of the inner mitochondrial membrane) to the mitochondrial genome, and being released into the mitochondrial matrix where it can degrade matrix proteins. At least three different roles or functions have been ascribed to Lon: 1) Proteolytic digestion of oxidized...
Source: Free Radical Biology and Medicine - July 3, 2016 Category: Biology Authors: Bota DA, Davies KJ Tags: Free Radic Biol Med Source Type: research

Long Distance Running Effects On Your Health
Long distance running is becoming more and more popular. Close to two million people every year drag themselves across the finish lines. And that’s just in half marathon races. Runners in these 13.1 mile events have increased six-fold over the past 25 years.  All these amateur athletes think they’re getting really healthy as they work themselves up to full marathons. But the truth is they are cutting years off their life.  You can see it for yourself if you stand at the finish line of any race. The hardcore runners look terrible. They look gaunt and malnourished. They are hunched over and have a stiff awkwa...
Source: Al Sears, MD Natural Remedies - June 20, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Fitness Source Type: news

Risk of death and stroke associated with anticoagulation therapy after mitral valve repair
Conclusion VKA treatment after mitral valve repair is associated with a markedly lower risk of adverse events as stroke or death without excess major bleeding risk during the first 3 months following surgery.
Source: Heart - April 11, 2016 Category: Cardiology Authors: Valeur, N., Merie, C., Hansen, M. L., Torp-Pedersen, C., Gislason, G. H., Kober, L. Tags: Drugs: cardiovascular system, Interventional cardiology, Epidemiology Valvular heart disease Source Type: research

Golf and Wellness: Enjoy Your Health in Full Swing
On June 11, 2016, over 3,000 properties in 83 countries will celebrate Global Wellness Day with the objective to touch the hearts and minds of 250 million people. Thousands of wellness activities will be organized, free of charge, by day spas and salons, hotel spas, fitness clubs, yoga/Pilates studios, ballet companies and dance schools, town halls, even golf clubs. Millions of people will be given the opportunity to try new fun and healthy activities, experience new sensations as bodies are pleasantly invited to breathe consciously, stretch to one's heart content, walk the talk, hike to discover new horizons, pack a scrum...
Source: Healthy Living - The Huffington Post - April 7, 2016 Category: Consumer Health News Source Type: news

This Vitamin Can Save Your Brain
Your brain has amazing abilities. And it can heal itself. That’s not something you’re likely to hear from mainstream medicine — especially if you or a loved one suffer from the effects of stroke, Alzheimer’s, Parkinson’s or another form of dementia. Here at the Sears Institute for Anti-Aging Medicine, I’ve seen many people with brain damage. And, sadly, most have been deemed “hopeless” by so-called medical experts. But I can tell you there is nothing hopeless about dementia — no matter what its cause. With the right nutrients, there are times when brain damage can be reversed. And now recent research from...
Source: Al Sears, MD Natural Remedies - December 23, 2015 Category: Complementary Medicine Authors: Al Sears Tags: Brain Health Alzheimer's dementia nutrients tocotrienol vitamin E Source Type: news

At UCLA, it's medicine 2.0
Tucked deep in the basement of UCLA’s Center for the Health Sciences is a room that looks more like an inventor’s fantasy workshop than the medical research facility it is. Tables are piled high with tools, electronics, prototype equipment parts and a few stray robotic arms. Posters on the wall describe pending projects in dense technical language with accompanying photos of futuristic devices. This hidden space is where scientists are working at the very forefront of technological advances in medicine. Its assemblage of smarts, parts and computers is contributing to an emerging era of personalized, tech-enabled health...
Source: UCLA Newsroom: Health Sciences - December 16, 2015 Category: Universities & Medical Training Source Type: news

Design Your Healthy and Happy Life With 3 Quick Makeovers: Small Steps Equal a Big Impact
Design your healthy and happy life with these super quick makeover tips that will have you wanting more. A healthy and happy life is about living blissfully, with passion and purpose, not just about the absence of disease. The great news is that we can design our own healthy lifestyle plan just like interior designers create beautiful spaces; we can design it no matter where we are in your own health journey; dealing with an illness, or recovering from an injury. What's even better news is that we don't need to do a complete overhaul. Who doesn't love a quick makeover? Sometimes, all it takes is new throw pillows or a bold...
Source: Healthy Living - The Huffington Post - September 29, 2015 Category: Consumer Health News Source Type: news

HeartStitch touts new PFO closure method
Structural heart focused HeartStitch said today its NobleStitch EL device was used to repair 3 patients with patent forman ovale heart defects in Astana, Kazakhstan. A patent foramen ovale is a congenital heart disease in which hole in the heart that normally seals at birth remains open, and can lead to severe migraines, visual auras and stroke, the company said. The procedures were performed by Dr. Michael Mullen and guided by Anthony Nobles at the National Research Cardiac Surgery Center in Astana, according to the company. “We are gratified that our colleagues from abroad have brought this technology to Kazakhstan...
Source: Mass Device - September 11, 2015 Category: Medical Equipment Authors: Fink Densford Tags: Cardiac Implants Cardiovascular HeartStitch Source Type: news

Abstract 1852: Merlin/NF2 is associated with elevated aromatase expression and estrogen formation in human liver tissues and liver cancer cells: An unifying model for hepatocellular carcinoma development and progression
It is recognized that the product of neurofibromatosis type 2 (NF2) tumor suppressor gene, also referred to as Merlin/neurofibromin, is implicated in the homeostatic regulation of the liver stem cell niche through the control of abundance and signaling of epidermal growth factor receptor (EGFR), with a mechanism independent of the Mst/Lats/Yap Hippo pathway [1]. We have previously reported that locally elevated estrogen formation, driven by abnormally high expression and function of the aromatase enzyme, may be implicated in both development and progression of human hepatocellular carcinoma (HCC) through the activation of ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Cocciadiferro, L., Miceli, V., Granata, O. M., Carruba, G. Tags: Endocrinology Source Type: research

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