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Antithrombotic therapy in patients with combined coronary heart disease and atrial fibrillation.
CONCLUSION: In each clinical scenario, the risks of coronary artery or stent thrombosis in CHD and risks of stroke in AF need to be carefully balanced against the risks of bleeding. We make recommendations for management based on the evidence which is available at this time and indicate the many gaps which are currently being addressed by randomised clinical trials. PMID: 26658287 [PubMed - as supplied by publisher]
Source: Panminerva Medica - December 15, 2015 Category: Journals (General) Tags: Panminerva Med Source Type: research

Incremental Value of the CRUSADE, ACUITY, and HAS-BLED Risk Scores for the Prediction of Hemorrhagic Events After Coronary Stent Implantation in Patients Undergoing Long or Short Duration of Dual Antiplatelet Therapy Coronary Heart Disease
Conclusions Our analysis suggests that the CRUSADE score predicts major bleeding similarly to ACUITY and better than HAS BLED in an all-comer population with percutaneous coronary intervention and potentially identifies patients at higher risk of hemorrhagic complications when treated with a long-term dual antiplatelet therapy regimen. Clinical Trial Registration URL: http://clinicaltrials.gov. Unique identifier: NCT00611286.
Source: JAHA:Journal of the American Heart Association - December 7, 2015 Category: Cardiology Authors: Costa, F., Tijssen, J. G., Ariotti, S., Giatti, S., Moscarella, E., Guastaroba, P., De Palma, R., Ando, G., Oreto, G., Zijlstra, F., Valgimigli, M. Tags: Coronary Heart Disease Source Type: research

A retrospective cross-sectional study on the association between tobacco smoking and incidence of ST-segment elevation myocardial infarction and cardiovascular risk factors
Conclusion Cigarette smoking is associated with a fivefold increased risk of STEMI. Smoking cessation reduced this risk to a level similar to never-smokers.
Source: Postgraduate Medical Journal - September 2, 2015 Category: Journals (General) Authors: Steele, L., Lloyd, A., Fotheringham, J., Sultan, A., Iqbal, J., Grech, E. D. Tags: Drugs: cardiovascular system, Stroke, Interventional cardiology, Ischaemic heart disease, Cardiothoracic surgery, Vascular surgery, Epidemiology Original article Source Type: research

Lean body mass index prognostic value for cardiovascular events in patients with coronary artery disease
Conclusions Lower LBMI values are associated with adverse outcomes in an Asian population with CHD undergoing PCI. LBMI is a better predictor of MACE than BMI or FMI. Clinical trial registration UMIN-ID; 000010070.
Source: Heart Asia - August 26, 2015 Category: Cardiology Authors: Hioki, H., Miura, T., Motoki, H., Kobayashi, H., Kobayashi, M., Nakajima, H., Kimura, H., Mawatari, E., Akanuma, H., Sato, T., Ebisawa, S., Miyashita, Y., Ikeda, U., On behalf of the SHINANO registry investigators, On behalf of the SHINANO registry invest Tags: Open access Cardiac risk factors and prevention Source Type: research

Cardiovascular Disease Treatment Outcomes in Patients with Diabetes: Prediction Models Using Artificial Neural Networks and Logistic Regression
Diabetes mellitus (DM) is not only a major risk factor for coronary heart disease (CHD); it also worsens CHD prognosis. The study's purpose was to investigate comparative effectiveness of two major CHD treatment procedures - coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) - in a population of CHD patients with DM (CHD-DM), using an artificial intelligence tool - artificial neural networks (ANN) - and a traditional multivariable logistic regression (MLR).
Source: Annals of Epidemiology - August 21, 2015 Category: Epidemiology Authors: Alexander V. Sergeev, Gary R. Weckman Tags: Cardiovascular Diseases and Stroke Source Type: research

Coronary artery bypass surgery continues to remain the treatment of choice for multivessel coronary artery disease even in the era of new-generation drug-eluting stents
Commentary on: Park SJ, Ahn JM, Kim YH, et al; BEST Trial Investigators. Trial of everolimus-eluting stents or bypass surgery for coronary disease. N Engl J Med 2015;372:1204–12. Context Multivessel coronary artery disease (MVCAD) may be found in patients subjected to coronary angiography. It is treated with coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). The expanded use of PCI, following development of drug-eluting stents (DES), necessitated comparison of its outcomes with CABG (gold standard therapy). The SYNTAX (SYNergy between PCI with TAXUS and Cardiac Surgery) trial favoured...
Source: Evidence-Based Medicine - July 24, 2015 Category: Internal Medicine Authors: Mohr, F. W., Davierwala, P. M. Tags: Clinical trials (epidemiology), Drugs: cardiovascular system, Stroke, Interventional cardiology, Ischaemic heart disease, Venous thromboembolism, Radiology, Clinical diagnostic tests, Radiology (diagnostics) Therapeutics/Prevention Source Type: research

Everolimus Eluting Stents Versus Coronary Artery Bypass Graft Surgery for Patients With Diabetes Mellitus and Multivessel Disease Coronary Artery Disease
Conclusions— In patients with diabetes mellitus and multivessel disease, EES was associated with lower upfront risk of death and stroke when compared with coronary artery bypass graft surgery. However, at long-term, EES was associated with similar risk of death, a higher risk of MI (in those with incomplete revascularization), and repeat revascularization but a lower risk of stroke.
Source: Circulation: Cardiovascular Interventions - July 8, 2015 Category: Cardiology Authors: Bangalore, S., Guo, Y., Samadashvili, Z., Blecker, S., Xu, J., Hannan, E. L. Tags: Type 2 diabetes, Catheter-based coronary interventions: stents, CV surgery: coronary artery disease, Chronic ischemic heart disease Source Type: research

Risk stratification using the CHA2DS2-VASc score in patients with coronary heart disease undergoing percutaneous coronary intervention; sub-analysis of SHINANO registry
Conclusions This study demonstrated that CHA2DS2-VASc score could provide prognostic information in CHD without known AF.
Source: IJC Heart and Vasculature - May 22, 2015 Category: Cardiology Source Type: research

0018 : Antithrombotic management in patients with atrial fibrillation undergoing stent implantation: An assessment of the ESC guidelines adherence
Conclusion Guidelines for antithrombotic therapy in patients with AF who undergo PCI and stent implantation are still poorly followed in clinical practice. OAC underused was associated with an increased risk of death in this population.
Source: Archives of Cardiovascular Diseases Supplements - May 8, 2015 Category: Cardiology Source Type: research

Abstract 263: Incidence of Recurrent Cardiovascular Events and Disease Burden Among High-Risk Patients with Hyperlipidemia Session Title: Poster Session II
Conclusions: CV event-related risk and long-term costs are significantly greater among high-risk patients with shorter time intervals between recurrent CV events. Underutilization of LLTs in these patients highlights the need for improving clinical management and treatment options for these patients.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Punekar, R. S., Fox, K. M., Richhariya, A., Fisher, M. D., Gandra, S. R., Cziraky, M. J., Toth, P. P. Tags: Session Title: Poster Session II Source Type: research

Coronary heart disease in moyamoya disease: are they concomitant or coincidence?
Abstract The purpose of this study was to determine the prevalence and characteristics of symptomatic coronary heart disease (CHD) in patients with moyamoya disease (MMD). This retrospective study evaluated 456 patients who received examination for MMD between 1995 and 2012. We reviewed the patients' medical history and coronary imaging, including conventional coronary angiography and coronary computed tomography angiogram (CTA). Among 456 patients with MMD, 21 (4.6%) patients were found to have symptomatic CHD. Ten patients were treated with coronary artery bypass graft or percutaneous coronary intervention for u...
Source: J Korean Med Sci - April 1, 2015 Category: Journals (General) Authors: Nam TM, Jo KI, Yeon JY, Hong SC, Kim JS Tags: J Korean Med Sci Source Type: research

Fasting may not be required before percutaneous coronary intervention
Commentary on: Hamid T, Aleem Q, Lau Y, et al.. Pre-procedural fasting for coronary interventions: is it time to change practice? Heart 2014;100:658–61. Implications for practice and research The results of this study suggest that percutaneous coronary intervention (PCI) can be safely conducted without preprocedural fasting. Revision is needed of current fasting protocols. The findings of Hamid and colleagues must be confirmed by further randomised trials. Context PCI is currently performed in hospitals around the world. This procedure is generally conducted with light sedation and local anaesthesia. Patients are rou...
Source: Evidence-Based Nursing - March 19, 2015 Category: Nursing Authors: de Aguilar-Nascimento, J. E., Feguri, G. R. Tags: Adult nursing, Pneumonia (infectious disease), TB and other respiratory infections, Stroke, Diet, Interventional cardiology, Ischaemic heart disease, Cardiothoracic surgery, Vascular surgery Source Type: research

Meta-analysis compares anticoagulant strategies in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention
Commentary on: Bangalore S, Toklu B, Kotwal A, et al. Anticoagulant therapy during primary percutaneous coronary intervention for acute myocardial infarction: a meta-analysis of randomised trials in the era of stents and P2Y12 inhibitors. BMJ 2014;349:g6419 Context Optimal anticoagulant therapy in patients receiving primary intervention for acute myocardial infarction (MI) is widely debated. Prior studies have been heterogeneous in doses and concomitant treatments such that it has been unclear whether effects have been those of newer medication or a result of changes in these co-interventions. A meta-analytic approach can ...
Source: Evidence-Based Medicine - March 17, 2015 Category: Internal Medicine Authors: Patti, G. Tags: Clinical trials (epidemiology), Drugs: cardiovascular system, Stroke, Interventional cardiology, Ischaemic heart disease, Venous thromboembolism, Radiology, Clinical diagnostic tests Therapeutics/Prevention Source Type: research

Bypass surgery is more cost-effective than percutaneous coronary interventions for most patients with multivessel or left main coronary artery disease
Commentary on: Cohen DJ, Osnabrugge RL, Magnuson EA, et al; SYNTAX Trial Investigators. Cost-effectiveness of percutaneous coronary intervention with drug-eluting stents versus bypass surgery for patients with 3-vessel or left main coronary artery disease: final results from the Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery (SYNTAX) trial. Circulation 2014;130:1146–57. Context The SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) trial compared outcomes of percutaneous coronary intervention (PCI) with drug eluting stents (DES) and coronary a...
Source: Evidence-Based Medicine - March 17, 2015 Category: Internal Medicine Authors: Agarwal, S., Kapadia, S. R. Tags: Health policy, Drugs: cardiovascular system, Stroke, Interventional cardiology, Ischaemic heart disease, Health economics, Health service research Economic analysis Source Type: research

Risk Stratification using the CHA2DS2–VASc score in Patients with Coronary Heart Disease Undergoing Percutaneous Coronary Intervention; Sub-analysis of SHINANO registry
Conclusions This study demonstrated that CHA2DS2–VASc score could provide prognostic information in CHD without known AF.
Source: IJC Heart and Vasculature - March 1, 2015 Category: Cardiology Source Type: research

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