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Exosomes Derived From Mesenchymal Stem Cells Pretreated With Ischemic Rat Heart Extracts Promote Angiogenesis via the Delivery of DMBT1
Cell Transplant. 2022 Jan-Dec;31:9636897221102898. doi: 10.1177/09636897221102898.ABSTRACTMesenchymal stem cell-derived exosomes (MSC-Exos) have been shown to promote angiogenesis. Treating MSCs with ischemic rat brain extracts was sufficient to augment their benefits in stroke. However, no similar analyses of ischemic heart extracts have been performed to date. We aim to determine whether MSC-Exos derived from MSCs pretreated with ischemic rat heart extract were able to promote angiogenesis and to clarify underlying mechanisms. ELISA (enzyme-linked immunosorbent assay) of heart extracts revealed a significant increase of ...
Source: Cell Transplantation - June 21, 2022 Category: Cytology Authors: Yi Xiao Ye Zhang Yuzhang Li Nanyin Peng Qin Liu Danyang Qiu Justin Cho Cesario V Borlongan Guolong Yu Source Type: research

Early Transplantation of Human Cranial Bone-derived Mesenchymal Stem Cells Enhances Functional Recovery in Ischemic Stroke Model Rats.
Authors: Oshita J, Okazaki T, Mitsuhara T, Imura T, Nakagawa K, Otsuka T, Kurose T, Tamura T, Abiko M, Takeda M, Kawahara Y, Yuge L, Kurisu K Abstract We analyzed the cell characteristics, neuroprotective, and transplantation effects of human cranial bone-derived mesenchymal stem cells (hcMSCs) in ischemic stroke model rats compared with human iliac bone-derived mesenchymal stem cells (hiMSCs). The expressions of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF ) as neurotrophic factors were analyzed in both MSCs. hiMSCs or hcMSCs were intravenously administered into ischemic st...
Source: Neurologia Medico-Chirurgica - January 22, 2020 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Factors affecting organ donation rate during devastating brain injuries: A 6-year data analysis.
Conclusions: Our findings showed that refusal by the family was the most common reason for failure of deceased organ donations. To maximize the number of procured organs, transplant communities need to focus on increasing awareness regarding brain death and organ donation and establish strategies to increase consent obtained from the families. PMID: 31903853 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - January 8, 2020 Category: Surgery Tags: Acta Chir Belg Source Type: research

Comparison of a portable device versus a specific spirometer for cough flow testing
Conclusions: In this evaluation, including patients with heterogeneous disorders and normal controls, CPF readings were on average significantly higher when measured using the equipment with the CPF testing dedicated software; moreover this device allows for a better assessment of the cough maneuvers including visualization of the cough flow-volume loops.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Maia Silva, A., Viamonte, S., Machado Vaz, I., Almeida, M., Gomes, A., Silva, F., Winck, J. C. Tags: Monitoring Airway Disease Source Type: research

The Application of Nanomaterials in Stem Cell Therapy for some Neurological Diseases.
Abstract Stem cell therapy provides great promising therapeutic benefits for various neurological disorders. Cell transplantation has emerged as cell replacement application for nerve damage. Recently, nanomaterials obtain wide development in various industrial and medical fields, and nanoparticles have been applied to neuro-medical field for tracking and treating nervous system diseases. Combining stem cell with nanotechnology has raised more and more attentions; and it has demonstrated that it has huge effects on clinical diagnosis and therapeutics in multiple central nervous system diseases, meanwhile, improvin...
Source: Current Drug Targets - March 28, 2017 Category: Drugs & Pharmacology Authors: Zhang G, Khan AA, Wu H, Chen L, Gu Y, Gu N Tags: Curr Drug Targets Source Type: research

French Intensive Care Society, International congress - Réanimation 2016.
C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guérin C, Dellamonica J, Jaber S, Similowski T, Quenot JP, Binquet C, Vinsonneau C, Barbar SD, Vinault S, Deckert V, Lemaire S, Hssain AA, Bruyère R, Souweine B, Lagrost L, Adrie C, Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Lheureux O, Trepo E, Hites M, Cotton F, Wolff F, Surin R, Créteur J, Vincent JL, Gustot T, Jacobs F, Taccone FS, Neuville M, Timsit JF, El-Hel...
Source: Australian Family Physician - May 31, 2016 Category: Primary Care Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubi Tags: Ann Intensive Care Source Type: research

Comparison of intracerebral transplantation effects of different stem cells on rodent stroke models
In the present study, induced pluripotent stem cells (iPSCs), induced neural stem cells (iNSCs), mesenchymal stem cells (MSCs) and an immortalized cell line (RMNE6), representing different characteristics of stem cells, were transplanted into normal and/or injured brain areas of rodent stroke models, and their effects were compared to select suitable stem cells for cell replacement stroke therapy. The rat and mice ischaemic models were constructed using the middle cerebral artery occlusion technique. Both electrocoagulation of the artery and the intraluminal filament technique were used. The behaviour changes and fates of ...
Source: Cell Biochemistry and Function - April 1, 2015 Category: Biochemistry Authors: Yun Wu, Jianyu Wu, Rongkai Ju, Zhiguo Chen, Qunyuan Xu Tags: Research Article Source Type: research

Stroke victim has forehead muscles transplanted into her cheek so she can smile
Sara McKay, 45, from Consett in County Durham says her army husband George, 43, has been her 'lifeline' after having to re-learn to walk and talk due to a paralysing stroke and brain tumour.
Source: the Mail online | Health - October 10, 2014 Category: Consumer Health News Source Type: news

Progressive multifocal cerebral infarction in a young kidney transplant recipient due to thrombotic microangiopathy
Conclusion: Cerebral ischemia in organ transplant recipient prompt one to consider thrombotic microangiopathy.
Source: BMC Nephrology - April 7, 2014 Category: Urology & Nephrology Authors: Arash HaghikiaMeike HeerenClemens BockmeyerBernd HaubitzWilfried Gwinner Source Type: research