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Condition: Brain Tumor
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Glutamate Transport and Preterm Brain Injury
Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1
1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom
Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and beh...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research
Late-onset vascular complications of radiotherapy for primary brain tumors: a case-control and cross-sectional analysis
CONCLUSIONS: Stroke prevalence is increased in long-surviving PBT patients treated with cranial RT.IMPLICATIONS FOR CANCER SURVIVORS: CV events are frequent in long survivors of PBT treated with cerebral RT. We propose a check list to guide management of late CV complications in adults treated with RT for PBT.PMID:37142871 | DOI:10.1007/s11764-023-01350-z
Source: Cancer Control - May 4, 2023 Category: Cancer & Oncology Authors: Mar ía-José Ibáñez-Juliá Alberto Picca Delphine Leclercq Giulia Berzero Julian Jacob Lo ïc Feuvret Charlotte Rosso Cristina Birzu Agusti Alentorn Marc Sanson Camille Tafani Flavie Bompaire Luis Bataller Kh ê Hoang-Xuan Jean-Yves Delattre Dimitri Ps Source Type: research
Nitrone-based Therapeutics for Neurodegenerative Diseases. Their use alone or in Combination with Lanthionines.
Abstract
The possibility of free radical reactions occurring in biological processes led to the development and employment of novel methods and techniques focused on determining their existence and importance in normal and pathological conditions. For this reason the use of Nitrones for spin trapping free radicals came into widespread use in the 1970s and 1980s when surprisingly the first evidence of their potent biological properties was first noted. Since then wide-spread exploration and demonstration of the potent biological properties of phenyl-tert-butylnitrone (PBN) and derivatives were shown in preclinical ...
Source: Free Radical Biology and Medicine - February 15, 2013 Category: Biology Authors: Floyd RA, Castro Faria Neto HC, Zimmerman GA, Hensley K, Towner RA Tags: Free Radic Biol Med Source Type: research
Incidence and prevalence of treated epilepsy among poor health and low-income Americans
Conclusions:
The Medicaid population has a high incidence and prevalence of epilepsy, in an order of magnitude greater than that reported in the US general population. This indigent population carries a disproportionate amount of the epilepsy burden and deserves more attention for its health care needs and support services.
Source: Neurology - May 20, 2013 Category: Neurology Authors: Kaiboriboon, K., Bakaki, P. M., Lhatoo, S. D., Koroukian, S. Tags: Cohort studies, Prevalence studies, Incidence studies, All Epilepsy/Seizures ARTICLE Source Type: research
New Windows into the Brain: Technological Advances in Detecting and Treating Neurological Disorders (P4.185)
CONCLUSIONS • Visualase is a new MRI-guided laser technology often used to treat hard-to-reach and otherwise inoperable brain and spine tumors. The procedure can be performed while a patient is awake and requires only one stitch to close the surgical site. The laser thermal ablation technique destroys lesions and also has proven to be effective for epilepsy patients. • The minimally invasive NICO BrainPath - detailed fiber-tracking combined with precise image-guidance - effectively treats subcortical and deep brain lesions as never before. The procedure is part of the Six Pillar Approach. The presenter is one of ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Bailes, J. Tags: Neurodiagnosis and Health Outcomes Source Type: research
Predictors of Poor Outcome in Bacterial Meningitis: Retrospective Analysis of Nationwide Inpatient Sample (P5.046)
CONCLUSIONS: In this retrospective study, every decade increase in age, teaching hospital status and development of complications like hydrocephalus, ischemic stroke, seizures, intracranial abscess and respiratory failure were predictors of poor outcome. Every calendar year increase was a negative predictor of poor outcome. Study Supported by:Disclosure: Dr. Dharaiya has nothing to disclose. Dr. Modi has nothing to disclose. Dr. Maraka has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Dharaiya, D., Modi, S., Maraka, S. Tags: Neuroepidemiology: Headache, Global Health, and Infectious Disease Source Type: research
The Feasibility and Outcome of Oro-esophageal Tube Feeding in Patients with Various Etiologies
Abstract
The oro-esophageal tube (OE tube) is widely used in dysphagia patients although its success rate for transition to oral feeding is reported only in stroke patients. The aim of this study was to evaluate the feasibility and outcome of OE tube feeding for patients with dysphagia resulting from various etiologies. The authors reviewed the medical records of 1995 dysphagic patients that had undergone videofluoroscopic swallowing study (VFSS) in a tertiary hospital from April 2002 through December 2009. Of these, 97 patients were recommended to use OE tube feeding based on the VFSS findings. Follow-up VFSS wer...
Source: Dysphagia - August 13, 2015 Category: Speech Therapy Source Type: research
The New Antiepileptic Drugs: Their Neuropharmacology and Clinical Indications.
Authors: Hanaya R, Arita K
Abstract
The administration of antiepileptic drugs (AEDs) is the first treatment of epilepsy, one of the most common neurological diseases. Therapeutic guidelines include newer AEDs as front-line drugs; monotherapy with new AEDs is delivered in Japan. While about 70% of patients obtain good seizure control by taking one to three AEDs, about 60% experience adverse effects and 33% have to change drugs. Compared to traditional AEDs, the prolonged administration of new AEDs elicits fewer adverse effects and fewer drug interactions and their teratogenicity may be lower. These characteristics i...
Source: Neurologia Medico-Chirurgica - March 6, 2016 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
Mania secondary to focal brain lesions: implications for understanding the functional neuroanatomy of bipolar disorder
ConclusionsSecondary mania should be suspected in patients with neurological deficits, histories atypical for classic bipolar disorder, and first manic episodes after the age of 40 years. Treatment with antimanic medications, along with specific treatment for the underlying neurologic condition, is typically required. Typical lesion locations fit with current models of bipolar disorder, which implicate hyperactivity of left‐hemisphere reward‐processing brain areas and hypoactivity of bilateral prefrontal emotion‐modulating regions. Lesion studies complement these models by suggesting that right‐hemisphere limbic‐...
Source: Bipolar Disorders - April 25, 2016 Category: Psychiatry Authors: David Satzer, David J Bond Tags: Review Article Source Type: research
Contribution of EEG in transient neurological deficits
AbstractIdentification of stroke mimics and ‘chameleons’ among transient neurological deficits (TND) is critical. Diagnostic workup consists of a brain imaging study, for a vascular disease or a brain tumour and EEG, for epileptiform discharges. The precise role of EEG in this diagnostic workup has, however, never been clearly delineated. However, this could be crucial in cases of atypical or incomplete presentation with consequences on disease management and treatment. We analysed the EEG patterns on 95 consecutive patients referred for an EEG within 7 days of a TND with diagnostic uncertainty. Patients were classifi...
Source: Journal of Neurology - November 15, 2017 Category: Neurology Source Type: research
Hotspots of small strokes in glioma surgery: an overlooked risk?
ConclusionDeep small infarcts are commonly found after glioma surgery, but their actual impact in terms of patients ’ quality of life remains to be demonstrated. Further studies are needed to better evaluate the cognitive consequences—if any—for each of the described hotspots and to identify risk factors other than the surgery-induced damage of microvessels.
Source: Acta Neurochirurgica - November 10, 2018 Category: Neurosurgery Source Type: research
Neuropsychological Assessments of Patients With Acquired Brain Injury: A Cluster Analysis Approach to Address Heterogeneity in Web-Based Cognitive Rehabilitation
We aimed to (1) apply cluster analysis techniques to mixed-type data (numerical and categorical) from baseline neuropsychological standard and widely used assessments of patients with acquired brain injury (ABI) (2) apply state-of-the-art cluster validity indexes (CVI) to assess their internal validity (3) study their external validity considering relevant aspects of ABI rehabilitation such as functional independence measure (FIM) in activities of daily life assessment (4) characterize the identified profiles by using demographic and clinically relevant variables and (5) extend the external validation of the obtained clust...
Source: Frontiers in Neurology - August 9, 2021 Category: Neurology Source Type: research
Return to Work for People With Aphasia
Right now, about 2.5 million people in the United States are living with aphasia after stroke.1 Aphasia can make it difficult to talk, listen, read, and/or write. Stroke is the most common cause of aphasia, but it can also happen after a traumatic brain injury (eg, blow to the head), a brain tumor, brain infection, or a neurodegenerative disease (eg, Alzheimer's dementia).2 Many people with aphasia are of working age, and this number is going up as more young people in the United States are sustaining stroke.
Source: Archives of Physical Medicine and Rehabilitation - April 5, 2022 Category: Rehabilitation Authors: Natalie Gilmore Tags: INFORMATION/EDUCATION PAGE Source Type: research
MRI for all: Cheap portable scanners aim to revolutionize medical imaging
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The patient, a man in his 70s with a shock of silver hair, lies in the neuro intensive care unit (neuro ICU) at Yale New Haven Hospital. Looking at him, you’d never know that a few days earlier a tumor was removed from his pituitary gland. The operation didn’t leave a mark because, as is standard, surgeons reached the tumor through his nose. He chats cheerfully with a pair of research associates who have come to check his progress with a new and potentially revolutionary device they are testing.
The cylind...
Source: Science of Aging Knowledge Environment - February 23, 2023 Category: Geriatrics Source Type: research
Late-onset vascular complications of radiotherapy for primary brain tumors: a case –control and cross-sectional analysis
ConclusionsStroke prevalence is increased in long-surviving PBT patients treated with cranial RT.Implications for cancer survivorsCV events are frequent in long survivors of PBT treated with cerebral RT. We propose a check list to guide management of late CV complications in adults treated with RT for PBT.
Source: Journal of Cancer Survivorship - May 5, 2023 Category: Cancer & Oncology Source Type: research
