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Assessing the influence of migraine on ischemic penumbra and on the prognosis of ischemic stroke: A prospective cohort study
CONCLUSION: Migraine is not associated with the absence of ischemic penumbra, the volume of the ischemic penumbra, or the stroke prognosis.PMID:36988078 | DOI:10.1111/head.14492
Source: Headache - March 29, 2023 Category: Neurology Authors: Felipe A A Oliveira Mario G Dourado-Filho Pedro A Sampaio Rocha-Filho Source Type: research

CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis
Cerebral autosomal dominant arteriopathy, subcortical infarcts, and leukoencephalopathy (CADASIL) is the most common monogenic form of small vessel disease characterized by migraine with aura, leukoaraiosis, strokes, and dementia. CADASIL mutations cause cerebrovascular dysfunction in both animal models and humans. Here, we showed that 2 different human CADASIL mutations (Notch3 R90C or R169C) worsen ischemic stroke outcomes in transgenic mice; this was explained by the higher blood flow threshold to maintain tissue viability compared with that in wild type (WT) mice. Both mutants developed larger infarcts and worse neurol...
Source: Journal of Clinical Investigation - April 15, 2022 Category: Biomedical Science Authors: Fumiaki Oka, Jeong Hyun Lee, Izumi Yuzawa, Mei Li, Daniel von Bornstaedt, Katharina Eikermann-Haerter, Tao Qin, David Y. Chung, Homa Sadeghian, Jessica L. Seidel, Takahiko Imai, Doga Vuralli, Rosangela M. Platt, Mark T. Nelson, Anne Joutel, Sava Sakadzic, Source Type: research

Stroke Mimics in the Acute Setting: Role of Multimodal CT Protocol ADULT BRAIN
CONCLUSIONS: Multimodal CT demonstrated low sensitivity but high specificity in the diagnosis of stroke mimics in the acute setting. The high specificity of multimodal CT allows ruling out stroke and thereby avoiding unnecessary revascularization treatment in patients with diagnosis of a stroke mimic.
Source: American Journal of Neuroradiology - February 4, 2022 Category: Radiology Authors: Prodi, E., Danieli, L., Manno, C., Pagnamenta, A., Pravata, E., Roccatagliata, L., Städler, C., Cereda, C. W., Cianfoni, A. Tags: ADULT BRAIN Source Type: research

Limb-shaking syndrome derived from the contralateral hemisphere following unilateral revascularisation for moyamoya disease
CONCLUSION: Revascularization for moyamoya disease can lead to watershed shifts, which can induce limb-shaking syndrome derived from abnormalities in the contralateral hemisphere of the revascularized side. For patients with new-onset limb-shaking syndrome after moyamoya revascularisation procedures, additional revascularization may be warranted for treatment of low perfusion areas.PMID:34877065 | PMC:PMC8645482 | DOI:10.25259/SNI_937_2021
Source: Surgical Neurology International - December 8, 2021 Category: Neurosurgery Authors: Munehiro Demura Masahiro Oishi Naoyuki Uchiyama Masanao Mohri Katsuyoshi Miyashita Mitsutoshi Nakada Source Type: research

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