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Second death linked to potential antibody treatment for Alzheimer ’s disease
A 65-year-old woman who was receiving a promising experimental treatment to slow the cognitive decline caused by her early Alzheimer’s disease recently died from a massive brain hemorrhage that some researchers link to the drug. The clinical trial death, described in an unpublished case report Science has obtained, is the second thought to be associated with the antibody called lecanemab. The newly disclosed fatality intensifies questions about its safety and how widely lecanemab should be prescribed if ultimately approved by regulators. The woman, who received infusions of the antibody as part of the trial, s...
Source: ScienceNOW - November 28, 2022 Category: Science Source Type: news

High Blood Pressure and Diabetes Are Linked. Here ’ s How to Reduce Your Risk for Both
High blood pressure—also known as hypertension—and Type 2 diabetes are two of the most common medical conditions in the U.S. Unfortunately, they often occur together. Some research has found that 85% of middle-aged or older adults who have Type 2 diabetes also have hyper­tension, and both conditions elevate a person’s risk for heart disease, stroke, and kidney disease. These increased risks are significant, and in some cases grave. Researchers have found that people with Type 2 ­diabetes are up to four times more likely to develop cardiovascular disease than those who don’t have the conditio...
Source: TIME: Health - August 29, 2022 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized Disease freelance healthscienceclimate Source Type: news

The demography of idiopathic normal pressure hydrocephalus: data on 3000 consecutive, surgically treated patients and a systematic review of the literature
CONCLUSIONS: Most iNPH patients undergo surgery in their 70s. Those aged < 60 years show slightly different symptomatology and probably present with a specific disease entity, indicating that the lower age limit for iNPH should be 60 years. iNPH patients have severe impairment preceded by a long diagnostic delay. Even though the included study designs differed, the systematic review showed that the disorder has a very low treatment incidence. The importance of diagnosing and treating iNPH is further emphasized by the fact that iNPH may account for a considerable part of all cases of dementia.PMID:35395629 | DOI:10.3171/2022.2.JNS212063
Source: Journal of Neurosurgery - April 8, 2022 Category: Neurosurgery Authors: Nina Sundstr öm Fredrik Lundin Lisa Arvidsson Mats Tullberg Carsten Wikkels ø Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

A case of neonatal onset multisystem inflammatory disease supporting a role of interleukin-1{beta} in moyamoya syndrome
Moyamoya syndrome (MMS) is a chronic progressive cerebrovascular condition characterized by bilateral stenosis/occlusion of the terminal internal carotid artery (ICA) often extending to neighboring cerebral arteries with prominent collateral circulation and increased risk of hemorrhage. Symptoms include stroke, TIA, and headache.1 MMS's etiology is unknown. However, experimental evidence from arterial smooth muscle cells (SMC) derived from patients with MMS has suggested that interleukin-1 beta (IL-1β)-dependent prostaglandin overproduction plays a crucial role in its pathogenesis.2 Neonatal onset multisystem inflamma...
Source: Neurology Neuroimmunology and Neuroinflammation - October 27, 2020 Category: Neurology Authors: Wohlrab, F., Bauknecht, C., Meisel, C., Dreier, J. P. Tags: Stroke in young adults, All Immunology, All Pediatric, Other neurocutaneous disorders Clinical/Scientific Notes Source Type: research

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

This Woman Woke Up With a British Accent. Here ’s What to Know About Foreign Accent Syndrome
This article originally appeared on Health.com
Source: TIME: Health - February 13, 2018 Category: Consumer Health News Authors: Jamie Ducharme / Health.com Tags: Uncategorized healthytime Mental Health/Psychology onetime Source Type: news

I ’ ve Been Seeing a Therapist for Years, So Why Am I Not Getting Better?
The answer: We need to address what’s happening inside the office as well as stigma. During the creation of the documentary Going Sane I interviewed Cindy Bulik. She is perhaps the most important researcher on anorexia today. She lives between UNC where she is a distinguished Professor of Eating Disorders and Sweden where she is a professor at the Karolinska Institute. Her current research is exploring genetic influences on anorexia and by the end of our interview she asked if my entire family would be willing to give a sample of blood for the study. She is not the single-minded professor oblivious to social customs tha...
Source: Psych Central - October 10, 2017 Category: Psychiatry Authors: Josh Sabey Tags: Disabilities Disorders Editorials Essays Medications Motivation and Inspiration Policy and Advocacy Psychology Psychotherapy Suicide Treatment Child Development child therapy Clinical Outcome evidence-based practices evidence Source Type: news

Migraine and risk of stroke: a national population-based twin study
In conclusion, we observed no increased stroke risk related to migraine overall but there was a modestly increased risk for stroke related to migraine with aura, and within-pair analyses suggested that familial factors might contribute to this association.
Source: Brain - September 26, 2017 Category: Neurology Source Type: research