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Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in mood disorders
Curr Med Chem. 2021 Sep 22. doi: 10.2174/0929867328666210922160116. Online ahead of print.ABSTRACTMajor depressive disorder (MDD) and bipolar disorders (BDs), the most severe types of mood disorders (MDs), are considered as among the most disabling illnesses worldwide. Several studies suggested that inflammatory neuroinflammation might be involved in the pathophysiology of MDs, while reporting increasing data on the relationships between these processes and classical neurotransmitters, hypothalamus-pituitary-adrenal axis (HPA), and neurotrophic factors. The assessment of neutrophil/lymphocyte ratio (NLR), platelet/lymphocy...
Source: Current Medicinal Chemistry - September 23, 2021 Category: Chemistry Authors: Donatella Marazziti Samuele Torrigiani Manuel G Carbone Federico Mucci Walter Flamini Tea Ivaldi Liliana Dell' Osso Source Type: research

Neuroserpin in Bipolar Disorder.
CONCLUSION: Since we detected difference between the patients and the controls, not the disease states, the dysregulation in the neuroserpin gene could be interpreted as a result of the disease itself. PMID: 32003693 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - January 30, 2020 Category: Chemistry Authors: Çınar RK Tags: Curr Top Med Chem Source Type: research

Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3 β inhibitors: A critical review.
Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3β inhibitors: A critical review. Eur J Med Chem. 2018 Dec 31;164:448-470 Authors: Xu M, Wang SL, Zhu L, Wu PY, Dai WB, Rakesh KP Abstract Glycogen Synthase Kinase-3 (GSK-3) is a constitutively dynamic, omnipresent serine/threonine protein kinase regularly called as a "multitasking kinase" due to its pliable function in diverse signaling pathways. It exists in two isoforms i.e., GSK-3α and GSK-3β. Inhibition of GSK-3 may be useful in curing various diseases such as Alzheimer's disease, type II diabetes, mood disorde...
Source: European Journal of Medicinal Chemistry - December 31, 2018 Category: Chemistry Authors: Xu M, Wang SL, Zhu L, Wu PY, Dai WB, Rakesh KP Tags: Eur J Med Chem Source Type: research

Molecules, Vol. 23, Pages 719: Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3 β Inhibitors
Molecules, Vol. 23, Pages 719: Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors Molecules doi: 10.3390/molecules23040719 Authors: Daniela Hulcová Kateřina Breiterová Tomáš Siatka Kamila Klímová Lara Davani Marcela Šafratová Anna Hošťálková Angela De Simone Vincenza Andrisano Lucie Cahlíková Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine protein kinase that was originally identified as an enzyme involved in the control of glycogen metabolism. It plays a key role in diverse physiological processes including metabolism, the cel...
Source: Molecules - March 21, 2018 Category: Chemistry Authors: Daniela Hulcov á Kate řina Breiterová Tom áš Siatka Kamila Kl ímová Lara Davani Marcela Šafratová Anna Ho šťálková Angela De Simone Vincenza Andrisano Lucie Cahl íková Tags: Article Source Type: research

Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage.
Abstract Novel isoselenazoles with high glutathione peroxidase (GPx) and peroxiredoxin (Prx) activities provide remarkable cytoprotection to human cells, mainly by exhibiting antioxidant activities in the presence of cellular thiols. The cytotoxicity of the isoselenazoles is found to be significantly lower than that of ebselen, which is being clinically evaluated by several groups for the treatment of reperfusion injuries and stroke, hearing loss, and bipolar disorder. The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species. PM...
Source: Angewandte Chemie - June 1, 2015 Category: Chemistry Authors: Bhowmick D, Srivastava S, D'Silva P, Mugesh G Tags: Angew Chem Int Ed Engl Source Type: research

Nonmuscle Myosin IIB Single Molecule Kinetics Enzymology
Nonmuscle myosin IIB (NMIIB) is a cytoplasmic myosin, which plays an important role in cell motility by maintaining cortical tension. It forms bipolar thick filaments with ∼14 myosin molecule dimers on each side of the bare zone. Our previous studies showed that the NMIIB is a moderately high duty ratio (∼20–25%) motor. The ADP release step (∼0.35 s−1) of NMIIB is only ∼3 times faster than the rate-limiting phosphate release (0.13 ± 0.01 s−1). The aim of this study was to relate the known in vitro kinetic parameters to the results of single molecule experiments and to compare the kinetic and mechanical prope...
Source: Journal of Biological Chemistry - January 4, 2013 Category: Chemistry Authors: Nagy, A., Takagi, Y., Billington, N., Sun, S. A., Hong, D. K. T., Homsher, E., Wang, A., Sellers, J. R. Tags: Molecular Biophysics Source Type: research