Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in mood disorders

Curr Med Chem. 2021 Sep 22. doi: 10.2174/0929867328666210922160116. Online ahead of print.ABSTRACTMajor depressive disorder (MDD) and bipolar disorders (BDs), the most severe types of mood disorders (MDs), are considered as among the most disabling illnesses worldwide. Several studies suggested that inflammatory neuroinflammation might be involved in the pathophysiology of MDs, while reporting increasing data on the relationships between these processes and classical neurotransmitters, hypothalamus-pituitary-adrenal axis (HPA), and neurotrophic factors. The assessment of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) in peripheral blood represents a simple method to evaluate the inflammatory status. The aim of the present paper was to review the literature on the possible relationships between NLR, PLR and MLR in MDs, and to comment on their possible wider use in clinical research. Thirty-five studies were included in the present review. The majority of them higher values of these parameters, particularly NLR values, in patients with MDs, when compared to healthy subjects. The increase would appear more robust in patients with BD during a manic episode, thus indicating that it could be considered as both state and trait markers. In addition, increased NLR and PLR levels seem to represent prognostic elements for the early discovery of post-stroke depression. The findings of the present review would indicate the need to ca...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Source Type: research

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Biomed Pharmacother. 2021 Nov;143:112175. doi: 10.1016/j.biopha.2021.112175. Epub 2021 Sep 27.ABSTRACTWithania somnifera (L.) Dunal (Solanaceae) has been used as a traditional Rasayana herb for a long time. Traditional uses of this plant indicate its ameliorative properties against a plethora of human medical conditions, viz. hypertension, stress, diabetes, asthma, cancer etc. This review presents a comprehensive summary of the geographical distribution, traditional use, phytochemistry, and pharmacological activities of W. somnifera and its active constituents. In addition, it presents a detailed account of its presence as...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
Mol Med Rep. 2021 Dec;24(6):839. doi: 10.3892/mmr.2021.12479. Epub 2021 Oct 11.ABSTRACTThe present study aimed to review major depression, including its types, epidemiology, association with different diseases status and treatments, as well as its correlation with the current COVID-19 pandemic. Mental depression is a common disorder that affects most individuals at one time or another. During depression, there are changes in mood and behavior, accompanied by feelings of defeat, hopelessness, or even suicidal thoughts. Depression has a direct or indirect relation with a number of other diseases including Alzheimer's disease...
Source: Molecular Medicine Reports - Category: Molecular Biology Authors: Source Type: research
This study aims to assess the trends in the incidence rate of neurological disorders in developed and developing countries worldwide during 1990-2019. The age-standardized incidence rate (per 100000 persons) of neurological disorders was the primary outcome, extracted from the Global Burden of Disease database for 189 countries and territories from 1990 to 2019. Using the Human Development Index (HDI), countries were classified into developed (HDI ≥ 0.7) and developing (HDI
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Source Type: research
This study aimed to present the relationship between cognitive impairment due to dementia, mood disorders and anxiety, and an increased risk of suicide among older people. Dementia is a disease where the risk of suicide is significant. Many studies demonstrated that older adults with dementia had an increased risk of suicide death than those without dementia. Similar conclusions apply to prodromal dementia Depression is also a disease with a high risk of suicide. Many researchers found that a higher level of depression was associated with suicide attempts and suicide ideation. Bipolar disorder is the second entity in mood ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Anarticle appearing today in theJournal of Neuropsychiatry and Clinical Neurosciences provides a comprehensive overview of the neurological and psychiatric impact of the COVID-19 pandemic.“Although best known for its severe effects on respiratory function, SARS-CoV-2 produces a broad range of acute and chronic neurological and neuropsychiatric problems,” wrote Theodora Manolis, M.D., of Red Cross Hospital in Athens, Greece, and colleagues. “The COVID-19 pandemic has also had an important impact on the mental health of many individuals in the general population as a result of loss of loved ones, fear of ca...
Source: Psychiatr News - Category: Psychiatry Tags: COVID-19 delirium depression headache hypoxia Journal of Neuropsychiatry and Clinical Neurosciences muscle pain neurological problems psychiatric problems psychosis stroke Source Type: research
Preoperative mood symptoms were related to physical pain and frailty. Taken together, these suggest that in patients without a formal psychiatric diagnosis, preoperative mood symptoms are related to physical state rather than a harbinger of early cognitive decline. Future studies are needed to understand the nature of the relationship between mood symptoms and physical state in surgical patients. AbstractObjectiveIn community dwelling older adults, depression and anxiety symptoms can be associated with early cognitive decline. Symptoms of depression and anxiety are common in older adults prior to surgery. However, their si...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSION: There is evidence of a potential benefit of SAMe as an intervention to help with symptoms across the range of post-concussive sequelae and syndromes commonly seen in military mTBI. Since the discovery of SAMe in 1952, this pleiotropic molecule has shown the significance of its involvement in several metabolic cascades in such disparate systems as epigenetics, bioenergetics, DNA methylation, neurotransmitter systems, and potential usefulness in military TBI. Significant limitations include disparate presentations seen in patients with mild TBI, those with post-concussive syndrome, as well as those with comorbid ...
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
In the United States (US), suicide is a leading cause of death, and most of these suicides involve firearms, highlighting the importance of lethal means safety in suicide prevention.(1, 2) US Veterans experience a suicide rate 1.5 times higher than US civilian adults and are more likely to use firearms as the means of suicide.(3) Risk factors for suicide within this population include demographic factors such as sex, age, race, and level of education, as well as health factors such as smoking status, psychiatric conditions (e.g., posttraumatic stress disorder [PTSD], depression, bipolar and anxiety disorders, schizophrenia...
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Tags: Original Research Source Type: research
In the United States (US), suicide is a leading cause of death, and most of these suicides involve firearms, highlighting the importance of lethal means safety in suicide prevention.1,2 US veterans experience a suicide rate 1.5 times higher than US civilian adults and are more likely to use firearms as the means of suicide.3 Risk factors for suicide within this population include demographic factors such as sex, age, race, and level of education, as well as health factors such as smoking status, psychiatric conditions (eg, posttraumatic stress disorder, depression, bipolar and anxiety disorders, schizophrenia, alcohol or o...
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Tags: ORIGINAL RESEARCH Source Type: research
By HANS DUVEFELT I have learned a few things about prescribing medications during my 42 years as a physician. Some are old lessons, and some are more recent. I thought I’d share some random examples. First: I don’t like to have to use medications, but when they seem necessary, I choose, present and prescribe them with great care. CHOOSING MEDICATIONS Medications are like people. They have personalities. With so many choices for any given diagnosis or symptom, I consider their mechanism of action, possible beneficial additional effects and their risk of unwanted side effects when selecting which one ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Patients Physicians Primary Care Hans Duvefelt Source Type: blogs
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