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Multifractal Desynchronization of the Cardiac Excitable Cell Network During Atrial Fibrillation. II. Modeling
In this study, we elaborate on a tentative interpretation of the observed intermittent dynamics during AF as the signature of synaptic plasticity. Typical individual GJC transition times between open and closed states were shown to be much longer than those of membrane polarization but compare well with membrane recovery time (≳ 100ms) (Spray et al., 1984; Neyton and Trautmann, 1986; Wang et al., 1992; Bukauskas and Verselis, 2004; Desplantez et al., 2007). Moreover, slow gating modulations have been evidenced due to cytoplasmic protons (low pH) and free calcium (Spray et al., 1984; Burt and Sray, 1988; Kumar and G...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Functional MRI of Letter Cancellation Task Performance in Older Adults
Conclusion The present work is the first to identify neural correlates of the LCT using fMRI and tablet technology in a healthy aging population. Across all ages, the activation was found to be bilateral, including in the cerebellum, superior temporal lobe, precentral gyrus, frontal gyrus, and various occipital and parietal areas. With increasing age, performance generally decreased and brain activity was reduced in the supplementary motor area, middle and inferior frontal gyrus, middle occipital gyrus, putamen and cerebellum. Better LCT performance was correlated with increased activity in the middle frontal gyrus, and r...
Source: Frontiers in Human Neuroscience - April 15, 2019 Category: Neuroscience Source Type: research

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research