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Specialty: Cardiology
Condition: Dementia

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Total 319 results found since Jan 2013.

Importance of Considering Competing Risks in Time-to-Event Analyses: Application to Stroke Risk in a Retrospective Cohort Study of Elderly Patients With Atrial Fibrillation Original Articles
Conclusions: The incidence of death without stroke was 9-fold higher than that of stroke, leading to biased estimates of stroke risk with traditional time-to-event methods. Statistical methods that appropriately account for competing risks should be used to mitigate this bias.
Source: Circulation: Cardiovascular Quality and Outcomes - July 11, 2018 Category: Cardiology Authors: Abdel-Qadir, H., Fang, J., Lee, D. S., Tu, J. V., Amir, E., Austin, P. C., Anderson, G. M. Tags: Atrial Fibrillation, Epidemiology, Primary Prevention, Cerebrovascular Disease/Stroke Original Articles Source Type: research

Maternal Stroke: an Update
AbstractPurpose of the ReviewMaternal morbidity and mortality is rising in the USA, and maternal stroke is a major contributor. Here, we review the epidemiology, risk factors, and current recommendations for diagnosis and acute treatment of ischemic and hemorrhagic stroke during pregnancy and postpartum, focusing on recent evidence.Recent FindingsThe incidence of maternal stroke has risen in recent years, possibly due to increasing rates of hypertensive disorders of pregnancy. The risk of maternal stroke is highest in the peripartum and early postpartum period. Preeclampsia is highly associated with reversible cerebral vas...
Source: Current Atherosclerosis Reports - June 21, 2019 Category: Cardiology Source Type: research

Post-Stroke Cognitive Impairment and Dementia
Circ Res. 2022 Apr 15;130(8):1252-1271. doi: 10.1161/CIRCRESAHA.122.319951. Epub 2022 Apr 14.ABSTRACTPoststroke cognitive impairment and dementia (PSCID) is a major source of morbidity and mortality after stroke worldwide. PSCID occurs as a consequence of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Cognitive impairment and dementia manifesting after a clinical stroke is categorized as vascular even in people with comorbid neurodegenerative pathology, which is common in elderly individuals and can contribute to the clinical expression of PSCID. Manifestations of cerebral small vessel disease, such...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Natalia S Rost Amy Brodtmann Matthew P Pase Susanne J van Veluw Alessandro Biffi Marco Duering Jason D Hinman Martin Dichgans Source Type: research

Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke
Circ Res. 2022 Apr 15;130(8):1167-1186. doi: 10.1161/CIRCRESAHA.121.319994. Epub 2022 Apr 14.ABSTRACTInflammation and immune mechanisms are crucially involved in the pathophysiology of the development, acute damage cascades, and chronic course after ischemic stroke. Atherosclerosis is an inflammatory disease, and, in addition to classical risk factors, maladaptive immune mechanisms lead to an increased risk of stroke. Accordingly, individuals with signs of inflammation or corresponding biomarkers have an increased risk of stroke. Anti-inflammatory drugs, such as IL (interleukin)-1β blockers, methotrexate, or colchicine, r...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Matthias Endres Maria A Moro Christian H Nolte Claudia Dames Marion S Buckwalter Andreas Meisel Source Type: research

Biomarkers and Risk Prediction Tools for Stroke and Dementia in Patients with Atrial Fibrillation
AbstractPurpose of ReviewWith the aging population, atrial fibrillation (AF) associations with both stroke and dementia have become a priority for the healthcare system. The purpose of this paper is to review the emerging role of clinical scores and biomarkers in the risk stratification of AF patients for risk of stroke and risk of dementia.Recent FindingsAF is the most common arrhythmia in the aging population and a common comorbidity in atherosclerotic disease and heart failure. In this review, we identified 34 most relevant papers that specifically address the role of biomarkers in risk-stratifying patients with AF with...
Source: Current Cardiovascular Risk Reports - October 1, 2020 Category: Cardiology Source Type: research

Post-stroke Cognitive Impairment and Malnutrition in the Elderly (PCIME): study design and protocol
CONCLUSION: PCIME will enable us to assess the role of malnutrition in development of post stroke dementia. This study will help clinicians and researchers develop preventive measures to reduce the burden of stroke and dementia.PMID:34900843 | PMC:PMC8630267 | DOI:10.1007/s40200-021-00841-z
Source: Atherosclerosis - December 13, 2021 Category: Cardiology Authors: Zahra Vahabi M Reza Azarpazhooh Shima Raeesi Shahram Oveisgharan Farnaz Etesam Elahe Abedi-Taleb Rezvan Hashemi Source Type: research

Preventing post-stroke dementia. The MARCH Trial. Protocol and statistical analysis plan of a randomized clinical trial testing the safety and efficacy of Maraviroc in post-stroke cognitive impairment
CONCLUSIONS: The results of this work could lead to a novel, readily available, therapeutic avenue to reduce PSCI, and possibly other pathologies. This study will test safety and effectiveness of Maraviroc in limiting cognitive deterioration and/or post stroke cognitive impairment in patients with cerebral small vessel disease.SCHEDULE: First-patient first-visit was May 2021. Recruitment to complete in 2023, follow-up to complete in 2024.PMID:36082248 | PMC:PMC9446318 | DOI:10.1177/23969873221098857
Source: Atherosclerosis - September 9, 2022 Category: Cardiology Authors: Einor Ben Assayag Jeremy Molad Estelle Seyman Ofer Rotschild Ehud Zeltzer Udi Sadeh-Gonik Noa Bregman Aviva Alpernas Yahel Segal Dafna Ben Bashat Talya Nathan Muhamad Hawwari Oren Tene Hen Hallevi Source Type: research

Stroke Risk and Vascular Dementia in South Asians
AbstractPurpose of ReviewSouth Asians (SA) are at a higher risk for stroke and vascular dementia due to the disproportionate burden of diabetes, hypertension, and dyslipidemia. This review summarizes the rationale for screening, early detection, and aggressive control of metabolic factors, and critically examines the published literature on primary and secondary stroke prevention.Recent FindingsSouth Asians have a higher prevalence of diabetes than non-SA. SA with diabetes are at a higher risk of recurrent ischemic stroke and have a higher incidence of stroke-related dementia compared to non-South Asians.SummarySouth Asian...
Source: Current Atherosclerosis Reports - July 5, 2018 Category: Cardiology Source Type: research

Preventing the Rise of AF-Stroke in Populations: A Call to Action.
Abstract Atrial fibrillation (AF) occurs in 1-1.5% of populations in developed countries and is independently associated with a 5-fold increase in stroke risk. Up to one-third of patients with first stroke in population studies have AF, with consequent greater neurological impairment, worse disability, increased recurrence risk, and more frequent dementia and requirement for institutional care compared to stroke of other causes(1,2). The prevalence of AF is highly age-dependent, ranging from 0.1% in those aged under 55 years to 9% in those aged 80 or older(3). With greater life-expectancy, the absolute numbers of ...
Source: Circulation - September 10, 2014 Category: Cardiology Authors: Kelly PJ Tags: Circulation Source Type: research