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Condition: Deafness

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Total 120 results found since Jan 2013.

Concomitant Mitochondrial Diabetes and Myopathy Mistook for Complications of Immunosuppressants After Kidney Transplant
We report the case of a 48-year-old woman with diabetes mellitus, sensorineural hearing loss, and severe myopathy without neuropathy after deceased donor kidney transplant. ShehadamitochondrialDNApointmutation at position 3243 (A>G), and mitochondrial diseases such as maternally inherited diabetes deafness or mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodeswere suspected.Diabetes andother symptoms following kidney transplant can often be overlooked as complications of immunosuppressants taken after kidney transplant. However, in patients without a known cause of their symptoms, appropriate exam...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - July 30, 2021 Category: Transplant Surgery Authors: Yong Hoon Shin Ae Jin Kim Han Ro Jae Hyun Chang Ji Yong Jung Woo Kyung Chung Hyun Hee Lee Source Type: research

The Spectrum of Maculopathy in Mitochondrial DNA A3243G Mutation: A Case Series of Six Patients
CONCLUSIONS: A single mtDNA point mutation at locus 3243 can result in a variety of clinical presentations (MELAS, MIDD, or CPEO). Ocular involvement may manifest as a perimacular/peripapillary RPE atrophy/deposit, which can variably impact central visual function (from asymptomatic to legal blindness). The discovery of such a maculopathy should prompt the ophthalmologist to complete the personal and family history, namely, asking for the presence of diabetes mellitus and/or deafness.PMID:33930928 | DOI:10.1055/a-1386-5826
Source: Klinische Monatsblatter fur Augenheilkunde - April 30, 2021 Category: Opthalmology Authors: Eirini Kaisari Fran çois-Xavier Borruat Source Type: research

Cochlear Implantation in Sporadic Vestibular Schwannoma and Other Retrocochlear Pathology: A Case Series
Conclusions: Appropriately selected patients with retrocochlear pathology may benefit from CI so long as the patient has a cochlear fluid signal and an intact cochlear nerve. Patients with sporadic VS patients and normal contralateral hearing exhibited guarded outcomes with CI, whereas most patients with non-VS retrocochlear pathologies demonstrated open-set speech understanding scores comparable to or slightly worse than conventional CI candidates. Since variable performance benefit is observed with CI in patients with retrocochlear pathology, counseling is imperative to align patient expectations with realistic outcomes.
Source: Otology and Neurotology - March 19, 2021 Category: ENT & OMF Tags: COCHLEAR IMPLANTS Source Type: research

Connexin Hemichannel Inhibitors with a Focus on Aminoglycosides
Biochim Biophys Acta Mol Basis Dis. 2021 Mar 9:166115. doi: 10.1016/j.bbadis.2021.166115. Online ahead of print.ABSTRACTConnexins are membrane proteins involved directly in cell-to-cell communication through the formation of gap-junctional channels. These channels result from the head-to-head docking of two hemichannels, one from each of two adjacent cells. Undocked hemichannels are also present at the plasma membrane where they mediate the efflux of molecules that participate in autocrine and paracrine signaling, but abnormal increase in hemichannel activity can lead to cell damage in disorders such as cardiac infarct, st...
Source: Biochimica et Biophysica Acta - March 12, 2021 Category: Biochemistry Authors: Cristina M Natha Varun Vemulapalli Mariana C Fiori Cheng-Wei T Chang Guillermo A Altenberg Source Type: research

Pure word deafness due to bilateral temporal lobe ischemic stroke occurring at different time points over the years: a case report on the insight of brain language network reorganization
Neurocase. 2021 Mar 9:1-7. doi: 10.1080/13554794.2021.1896744. Online ahead of print.ABSTRACTHere we present a case of a native Greek male patient who presented clinically with sudden onset pure word deafness after an ischemic stroke in the temporoparietal region of the right hemisphere, but who had suffered an ischemic stroke 9 years previously in an adjacent area of the left hemisphere, causing aphasic symptoms which resolved quickly and almost completely. What makes this case interesting and novel is that it is the first case describing a patient whose ventral language comprehension circuit did not reorganize successful...
Source: Neurocase - March 9, 2021 Category: Neurology Authors: Ioanna-Eleni Virvidaki Lambros Messinis Grigorios Nasios Source Type: research