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Pulmonary hypertension: An unexplored risk factor for stroke in patients with atrial fibrillation
Atrial fibrillation (Afib) is one of the most common and significant risk factors for stroke, with the CHADsVAsc score used as the tool for stroke risk assessment. Pulmonary hypertension (PH) has not been studied as an independent risk factor for stroke in individuals with Afib.
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2023 Category: Neurology Authors: Georges Khattar, Ahmad Mustafa, Fasih Sami Siddiqui, Khalil El Gharib, Wei Chapman, Saif Abu Baker, Saud Bin Abdul Sattar, Dany Elsayegh, Halim El-Hage, Suzanne El Sayegh, Michel Chalhoub Source Type: research

A Novel Factor in Determining the Risk of Ischemic Cerebrovascular Events in Patients with Atrial Fibrillation: Pulmonary Hypertension
Pulmonary hypertension (PH) is closely related to clinical decompensation and poor clinical outcomes in atrial fibrillation (AF) patients. However, the association between PH and ischemic cerebrovascular events (ICE) in AF patients has not been investigated. The authors purposed to examine this relationship.
Source: Journal of Stroke and Cerebrovascular Diseases - February 16, 2022 Category: Neurology Authors: Serhat Karadavut, Murat Cetin Source Type: research

Paradoxical Cerebral Embolism as Initial Manifestation of Chronic Thromboembolic Pulmonary Hypertension: A Case Report
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by chronic thrombi in the pulmonary arteries, causing pulmonary hypertension and right heart failure. Early and accurate diagnosis are essential for successful treatment but are often difficult because clinical signs and symptoms can be nonspecific and risk factors, such as history of venous thromboembolism, may not always be present. Here, we report a case involving a 76-year-old woman who demonstrated paradoxical cerebral embolism as the initial manifestation of CTEPH.
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2019 Category: Neurology Authors: Akira Machida, Itsuki Soejima, Takeshi Bo, Eiichiro Amano, Kiyobumi Ota, Yoshinori Kanno, Tsunekazu Kakuta Tags: Case Report Source Type: research

Association of Transthoracic Echocardiography Findings and Long-Term Outcomes in Patients Undergoing Workup of Stroke
Transthoracic echocardiography (TTE) has become routine as part of initial stroke workup to assess for sources of emboli. Few studies have looked at other TTE findings such as ejection fraction, wall motion abnormalities, valve disease, pulmonary hypertension and left ventricular hypertrophy and their association with various subtypes of stroke, long-term outcomes of recurrent stroke, and all-cause mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Jeremy A. Miles, Leonid Garber, Subha Ghosh, Daniel M. Spevack Source Type: research

Mechanical Thrombectomy in an Infant With Acute Embolic Stroke
This 9-month-old previously healthy male infant was admitted with acute respiratory failure because of parainfluenza infection, requiring intubation. On the day after admission, an acute pulmonary hypertension crisis caused cardiovascular collapse and led to initiation of venoarterial extracorporeal membrane oxygenation (ECMO) with standard therapeutic anticoagulation. The following day, on routine neurological assessment, the patient was noted to have bilateral fixed and dilated pupils. With decreased rates of sedative and paralytic infusions, he was noted to only move the left side of his body with preserved lower brainstem activity.
Source: Pediatric Neurology - February 15, 2018 Category: Neurology Authors: Lisa R. Sun, Monica Pearl, Mona N. Bahouth, Melisa Carrasco, Katherine Hoops, Jennifer Schuette, Ryan J. Felling Tags: Clinical Letter Source Type: research

Mechanical Thrombectomy in an Infant with Acute Embolic Stroke
A 9-month-old previously healthy male infant was admitted with acute respiratory failure due to parainfluenza infection requiring intubation. On the day after admission, an acute pulmonary hypertension crisis causing cardiovascular collapse led to initiation of venoarterial extracorporeal membrane oxygenation (ECMO) with standard therapeutic anticoagulation. The following day, on routine neurologic assessment, the patient was noted to have bilateral fixed and dilated pupils. With decreased rates of sedative and paralytic infusions, he was noted to only move the left side of his body with preserved lower brainstem activity.
Source: Pediatric Neurology - February 15, 2018 Category: Neurology Authors: Lisa R. Sun, Monica Pearl, Mona N. Bahouth, Melisa Carrasco, Katherine Hoops, Jennifer Schuette, Ryan J. Felling Tags: Clinical Letter Source Type: research

Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog Basic Sciences
Conclusions—Our data suggest that targeting the IP receptor with MRE-269 is a novel strategy to reduce cerebral ischemia injury and promote long-term neurological recovery in ischemic stroke.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Changjun Yang, Kelly M. DeMars, Jon C. Alexander, Marcelo Febo, Eduardo Candelario-Jalil Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Chapter 13 Hereditary hemorrhagic telangiectasia
Publication date: 2015 Source:Handbook of Clinical Neurology, Volume 132 Author(s): Melissa G. Chung Hereditary hemorrhagic telangiectasia (HHT) also known as Osler–Weber–Rendu syndrome, is an autosomal dominant disorder that is characterized by multiple arteriovenous malformations (AVMs) involving the skin, mucosal surfaces, and internal organs. HHT has an age-dependent penetrance and usually initially presents with recurrent epistaxis followed by the characteristic telangiectasias of the face, oropharynx, and hands over time. Patients often have vascular malformations that involve their lungs, brain, spinal cord, ...
Source: Handbook of Clinical Neurology - November 18, 2015 Category: Neurology Source Type: research

CNS-disease affecting the heart: Brain–heart disorders
Abstract: There are a number of hereditary and non-hereditary central nervous system (CNS) disorders, which directly or indirectly affect the heart (brain–heart disorders). The most well-known of these CNS-disorders are epilepsy, stroke, subarachanoid bleeding, bacterial meningitis, and head injury. In addition, a number of hereditary and non-hereditary neurodegenerative disorders may impair cardiac functions. Affection of the heart may manifest as arrhythmias, cardiomyopathy, or autonomic dysfunction. Rarer cardiac complications of CNS disorders include heart failure, systolic or diastolic dysfunction, myocardial infarc...
Source: Journal of the Neurological Sciences - July 10, 2014 Category: Neurology Authors: Josef Finsterer, Karim Wahbi Tags: Reviews Source Type: research