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Specialty: Cancer & Oncology
Condition: Bleeding
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Total 42 results found since Jan 2013.
< em > ABCG2 < /em > Gene Polymorphisms May Affect the Bleeding Risk in Patients on Apixaban and Rivaroxaban
CONCLUSION: The modified HAS-BLED score, a history of bleeding, concurrent use of PPI, ABCG2 rs3114018, and ABCB1 rs1045642 were significantly associated with the risk of bleeding complications in patients on apixaban and rivaroxaban, after adjusting for other confounders. These findings can be used to develop individualized treatment strategies for patients taking apixaban and rivaroxaban.PMID:37641689 | PMC:PMC10460569 | DOI:10.2147/DDDT.S417096
Source: Cancer Control - August 29, 2023 Category: Cancer & Oncology Authors: Hamin Kim Tae-Jin Song Jeong Yee Dong-Hyeok Kim Junbeom Park Hye Sun Gwak Source Type: research
Investigation of Factors That Affect the Quality of Life After a Stroke
Adv Exp Med Biol. 2023;1425:437-442. doi: 10.1007/978-3-031-31986-0_42.ABSTRACTStroke, as a disease, describes a group of disorders characterized by the presence of central nervous system symptoms either as a result of ischemia (ischemic stroke) or bleeding (hemorrhagic stroke). The appearance of a stroke results in a permanent physical or cognitive disability. The stroke incidence is the third cause of death after heart disease and cancer, and is the main cause of long-term disability.The effects of a stroke on a patient's daily life, and hence on his quality of life, are intense and long-lasting. These include memory pro...
Source: Cancer Control - August 15, 2023 Category: Cancer & Oncology Authors: Maria Malliarou Christina Tsionara Anna Patsopoulou Axilleas Bouletis Vasileios Tzenetidis Iokasti Papathanasiou Evangelia Kotrotsiou Mary Gouva Athanasios Nikolentzos Pavlos Sarafis Source Type: research
Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation and Cancer
CONCLUSIONS: Within our cohort, LAAO in cancer patients was achieved with good procedural success and offered a reduction in stroke at no increased bleeding risk similar to noncancer patients.PMID:37144110 | PMC:PMC10152198 | DOI:10.1016/j.jaccao.2022.10.016
Source: Cancer Control - May 5, 2023 Category: Cancer & Oncology Authors: Samuel A Shabtaie Nicholas Y Tan Robert C Ward Bradley R Lewis Eric H Yang David R Holmes Joerg Herrmann Source Type: research
Cancers, Vol. 15, Pages 2574: Systematic Review and Meta-Analysis of Oral Anticoagulant Therapy in Atrial Fibrillation Cancer Patients
Conclusions: Anticoagulation with DOACs provides a higher safety profile with respect to VKAs in terms of stroke reduction and a relative bleeding reduction risk. Further studies are needed to better assess the optimal anticoagulation strategy in cancer patients with AF.
Source: Cancers - April 30, 2023 Category: Cancer & Oncology Authors: Alberto Cereda Stefano Lucreziotti Antonio Gabriele Franchina Alessandra Laricchia Valentina De Regibus Barbara Conconi Matteo Carl à Andrea Spangaro Matteo Rocchetti Luca Ponti Alessandro Minardi Elena Sala Giuseppe Massimo Sangiorgi Gabriele Tumminello Tags: Review Source Type: research
Atrial fibrillation, cancer and anticancer drugs
Arch Cardiovasc Dis. 2023 Mar 11:S1875-2136(23)00058-X. doi: 10.1016/j.acvd.2023.02.005. Online ahead of print.ABSTRACTActive cancer is associated with an increased risk of atrial fibrillation (AF), which varies depending on the pre-existing substrate (particularly in older patients), the cancer type and stage, and the anticancer therapeutics being taken. To date, studies have not been able to identify the individual contribution of each factor. During anticancer drug therapy, AF may occur with a frequency of ≈ 15-20% according to several factors, including the patient's baseline cardiovascular toxicity risk and the AF-d...
Source: Cancer Control - March 31, 2023 Category: Cancer & Oncology Authors: Jonaz Font Paul Milliez Alexandre-Boudjema Ouazar Frederikus A Klok Joachim Alexandre Source Type: research
Comparative Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin Among Adults With Cancer and Atrial Fibrillation
CONCLUSIONS: Older adults with cancer and atrial fibrillation exposed to DOACs had similar risks of stroke and systemic embolism and major bleeding as those exposed to warfarin. Relative to warfarin, DOAC use was associated with a similar risk of cardiovascular death and a lower risk of all-cause death.PMID:36453260 | DOI:10.1161/CIRCOUTCOMES.122.008951
Source: Cancer Control - December 1, 2022 Category: Cancer & Oncology Authors: Hemalkumar B Mehta Huijun An Shirin Ardeshirrouhanifard Mukaila A Raji G Caleb Alexander Jodi B Segal Source Type: research
Risk of mortality and other adverse outcomes from myocardial infarction in cancer survivors: a meta-analysis
ConclusionThis meta-analysis shows that cancer increases the risk of all-cause mortality, recurrent MI, and major bleeding in MI patients but is not associated with the risk of cardiovascular death. Therefore, comprehensive multidisciplinary management and monitoring of potential future adverse events in MI patients with cancer are needed.Systematic review registrationThe meta-analysis was registered in the International Register of Prospective Systematic Reviews (NO. CRD42022332775).
Source: International Journal of Clinical Oncology - November 28, 2022 Category: Cancer & Oncology Source Type: research
Renal outcomes in valve-in-valve transcatheter versus redo surgical aortic valve replacement: A systematic review and meta-analysis
CONCLUSION: Renoprotective strategies should be put into place to prevent and reduce AKI incidence regardless of the treatment modality. Patients undergoing re-intervention for the aortic valve constitute a high-risk and frail population in which ViV-TAVR demonstrated it might be a feasible option for carefully selected patients. Long-term follow-up data and randomized control trials will be needed to evaluate mortality and morbidity outcomes between these 2 treatments.PMID:36040611 | DOI:10.1111/jocs.16890
Source: Cancer Control - August 30, 2022 Category: Cancer & Oncology Authors: Arian Arjomandi Rad Vinci Naruka Robert Vardanyan Mohammad Yousuf Salmasi Panagiotis T Tasoudis Simon Kendall Roberto Casula Thanos Athanasiou Source Type: research
Association between self-reported gingival bleeding and prevalent hypertension among adults in a cross-sectional study in Zhejiang province
Conclusion: Frequent gingival bleeding was positively associated with prevalent hypertension among men.PMID:35981987 | DOI:10.3760/cma.j.cn112338-20210922-00744
Source: Cancer Control - August 18, 2022 Category: Cancer & Oncology Authors: H Wang L L Chen Y Q Guan Y Cao D Shen K X Xie X Y Zhang C M Wang P Pei Y Guo M Yu L M Chen Liming Li Source Type: research
Cancers, Vol. 14, Pages 3049: Mortality and Major Cardiovascular Events among Patients with Multiple Myeloma: Analysis from a Nationwide French Medical Information Database
Conclusions: From a large nationwide database, we demonstrated that MM patients do not have a higher risk of CV death or even a lower risk of both MI and ischaemic stroke. Conversely, MM patients had a higher risk of both major and intracranial bleedings, highlighting the key issue of thromboprophylaxis in these patients.
Source: Cancers - June 21, 2022 Category: Cancer & Oncology Authors: Yves Cottin Mathieu Boulin Clara Doisy Morgane Mounier Denis Caillot Marie Lorraine Chretien Alexandre Bodin Julien Herbert Bernard Bonnotte Marianne Zeller Marc Maynadi é Laurent Fauchier Tags: Article Source Type: research
Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke
Cell Mol Life Sci. 2022 Apr 13;79(5):240. doi: 10.1007/s00018-022-04257-7.ABSTRACTIschemic stroke is a leading cause of death and disability worldwide. Increasing evidence indicates that ischemic stroke is a thromboinflammatory disease in which the contact-kinin pathway has a central role by activating pro-coagulant and pro-inflammatory processes. The blocking of distinct members of the contact-kinin pathway is a promising strategy to control ischemic stroke. Here, a plasma kallikrein and active FXII (FXIIa) inhibitor (sylvestin, contained 43 amino acids, with a molecular weight of 4790.4 Da) was first identified from fore...
Source: Cancer Control - April 13, 2022 Category: Cancer & Oncology Authors: Zhiye Zhang Chuanbin Shen Mingqian Fang Yajun Han Chengbo Long Weihui Liu Min Yang Ming Liu Dengdeng Zhang Qiqi Cao Xue Chen Yaqun Fang Qiumin Lu Zongliu Hou Yaxiong Li Zhenze Liu Xi Lei Heyu Ni Ren Lai Source Type: research
Anticoagulation for atrial fibrillation in active cancer
Oncol Lett. 2022 Apr;23(4):124. doi: 10.3892/ol.2022.13244. Epub 2022 Feb 17.ABSTRACTAtrial fibrillation (AF) may often pre-exist in patients with newly diagnosed cancer or occur with increased frequency shortly after cancer diagnosis. Patients with active cancer and AF have a particularly high risk of thromboembolic complications, as both conditions carry a risk of thrombosis. Thromboembolic risk is determined by several factors, including advanced age, sex (females), cancer histology (adenocarcinomas), location (e.g., pancreas, stomach), advanced stage, anticancer regimens (e.g., platinum compounds, anti-angiogenic thera...
Source: Oncology Letters - March 9, 2022 Category: Cancer & Oncology Authors: Dimitrios Farmakis Pavlos Papakotoulas Eleni Angelopoulou Theodoros Bischiniotis George Giannakoulas Panagiotis Kliridis Dimitrios Richter Ioannis Paraskevaidis Source Type: research
