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Specialty: Respiratory Medicine
Condition: Bleeding

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Total 261 results found since Jan 2013.

Intracranial haemorrhage and subsequent ischemic stroke in patients with atrial fibrillation: A nationwide cohort study.
Conclusion:In this large-scale study of AF patients treated with warfarin, first-time ICH was associated with an increased rate of ischaemic stroke/SE/TIA and mortality compared to the non-ICH group. There was a decrease in the warfarin prescription purchase rate post-ICH period compared to pre-ICH, which may partly explain the excess risk. Background: The risk of ischemic stroke/thromboembolic events after an intracranial haemorrhage (ICH) in atrial fibrillation (AF) patients on warfarin treatment is poorly characterised. The aim of this study was to assess the association between the risk of ischaemic stroke/thrombo...
Source: Chest - November 20, 2014 Category: Respiratory Medicine Authors: Nielsen PB, Larsen TB, Gorst-Rasmussen A, Skjøth F, Rasmussen LH, Lip GY Tags: Chest Source Type: research

The impact of associated diabetic retinopathy on stroke and severe bleeding risk in diabetic patients with atrial fibrillation: The Loire Valley Atrial Fibrillation Project.
ConclusionCrude rates of stroke/TE increased in a stepwise fashion when non-diabetic AF patients were compared to diabetics with no retinopathy and diabetics with retinopathy. However, we have shown for the first time that the presence of diabetic retinopathy did not emerge as an independent predictor for stroke/TE or severe bleeding on multivariate analysis. Background: Diabetes mellitus is recognized as a stroke risk factor in atrial fibrillation (AF). Diabetics with retinopathy have an increased risk of systemic cardiovascular complications, and also, severe diabetic retinopathy predisposes to ocular bleeds. We hyp...
Source: Chest - November 20, 2014 Category: Respiratory Medicine Authors: Lip GY, Clementy N, Pierre B, Boyer M, Fauchier L Tags: Chest Source Type: research

Development of a novel composite stroke and bleeding risk score in patients with atrial fibrillation: The AMADEUS study.
CONCLUSION We have developed and validated 2 novel composite scores for stroke/thromboembolism/ bleeding that offer good discriminatory and predictive performance. However, these composite risk scores did not perform better than the easier and more practical 'traditional' stroke and bleeding risk scores that are currently in use, which allow greater practically and more personalised balancing of risks. PMID: 24009027 [PubMed - as supplied by publisher]
Source: Chest - September 5, 2013 Category: Respiratory Medicine Authors: Lip GY, Lane DA, Buller H, Apostolakis S Tags: Chest Source Type: research

Time trends of aspirin and warfarin use on stroke and bleeding events in Chinese patients with new-onset atrial fibrillation.
Conclusion: Aspirin use increased amongst newly diagnosed Chinese AF patients with no relationship to the patient's stroke or bleeding risk. Warfarin use was very low. Given the healthcare burden of AF and its complications, our study has major implications for healthcare systems in non-Western countries, given the global burden of this common arrhythmia. PMID: 25501045 [PubMed - as supplied by publisher]
Source: Chest - December 11, 2014 Category: Respiratory Medicine Authors: Guo Y, Wang H, Tian Y, Wang Y, Lip GY Tags: Chest Source Type: research

Recalibration of the HAS-BLED score - should haemorrhagic stroke account for 1 or 2 points?
Abstract Following a haemorrhagic stroke, it is uncertain whether this event scores 1 point (either for Stroke or Bleeding) or 2 points (1 point each for Stroke and Bleeding) on the HAS-BLED score. We investigated the value of a recalibration of the HAS-BLED score to account for 2 points from a haemorrhagic stroke. We analysed data from the Danish nationwide cohort of incident atrial fibrillation (AF) patients from January 1999 to December 2013. The primary outcome in this observational study was major bleeding. The original- and the recalibrated HAS-BLED scores were assessed and event rates of major bleeding...
Source: Chest - September 10, 2015 Category: Respiratory Medicine Authors: Nielsen PB, Larsen TB, Lip GY Tags: Chest Source Type: research

Relationship of the SAME-TT2R2score to poor quality anticoagulation, stroke, clinically relevant bleeding and mortality in patients with atrial fibrillation.
CONCLUSION We demonstrate that the SAME-TT2R2 score was predictive for an increasing risk of stroke/TE, severe bleeding, major BARC bleeding and death, reflecting poor anticoagulation control (and labile INRs) on VKA amongst our patients with AF. PMID: 24722973 [PubMed - as supplied by publisher]
Source: Chest - April 10, 2014 Category: Respiratory Medicine Authors: Lip GY, Haguenoer K, Saint-Etienne C, Fauchier L Tags: Chest Source Type: research

Patent foramen ovale and stroke in intermediate-risk pulmonary embolism.
CONCLUSIONS: PFO and related ischemic strokes are frequent in intermediate-risk pulmonary embolism. TEE is much more efficient than TTE for PFO diagnostic. Considering the high risk of intra-cranial bleeding with thrombolysis in PE, which in part may be due to haemorrhagic transformation of sub-clinical strokes, screening PFO with TEE should be considered in intermediate risk PE when a thrombolytic treatment is discussed. PMID: 24874409 [PubMed - as supplied by publisher]
Source: Chest - May 29, 2014 Category: Respiratory Medicine Authors: Doyen D, Castellani M, Moceri P, Chiche O, Lazdunski R, Bertora D, Cerboni P, Chaussade C, Ferrari E Tags: Chest Source Type: research

Stroke, Major Bleeding and Mortality Outcomes in Warfarin Users with Atrial Fibrillation and Chronic Kidney Disease: A Meta-analysis of Observational Studies.
Conclusions: Based on this meta-analysis, the use of warfarin for AF may have an unfavorable risk/benefit ratio in patients with end-stage CKD but not in those with non-end stage CKD. PMID: 26378611 [PubMed - as supplied by publisher]
Source: Chest - September 17, 2015 Category: Respiratory Medicine Authors: Dahal K, Kunwar S, Rijal J, Schulman P, Lee J Tags: Chest Source Type: research

Major Bleeding and Hemorrhagic Stroke with Direct Oral Anticoagulants in Patients with Renal Failure: Systematic Review and Meta-Analysis of Randomized Trials.
CONCLUSIONS: As a class, DOACs are associated with reduced risk for hemorrhagic stroke in patients with RF compared to VKA. However, DOACs may differ from each other in their relative risk for major bleeding in patients with eCrCL <50mL/min. PMID: 26836922 [PubMed - as supplied by publisher]
Source: Chest - January 18, 2016 Category: Respiratory Medicine Authors: Raccah BH, Perlman A, Danenberg HD, Pollak A, Muszkat M, Matok I Tags: Chest Source Type: research

Author Credential Error in: Bleeding and Stroke Risk in a Real-world Prospective Primary Prevention Cohort of Patients With Atrial Fibrillation.
Authors: PMID: 23918138 [PubMed - in process]
Source: Chest - August 1, 2013 Category: Respiratory Medicine Tags: Chest Source Type: research

Using the scoring schemes in the right way: the dynamic assessment of stroke and bleeding risk in patients with atrial fibrillation.
Authors: Chao TF, Chen SA PMID: 30023127 [PubMed]
Source: Journal of Thoracic Disease - July 21, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Antithrombotic Therapy for Atrial Fibrillation: CHEST Guideline and Expert Panel Report.
CONCLUSIONS: Oral anticoagulation is the optimal choice of antithrombotic therapy for patients with AF with ≥1 non-gender CHA2DS2VASc stroke risk factor(s). PMID: 30144419 [PubMed - as supplied by publisher]
Source: Chest - August 21, 2018 Category: Respiratory Medicine Authors: Lip GYH, Banerjee A, Boriani G, Chiang CE, Fargo R, Freedman B, Lane DA, Ruff CT, Turakhia M, Werring D, Patel S, Moores L Tags: Chest Source Type: research

Clinical characteristics and outcomes in extreme elderly (age ≥85) Japanese patients with atrial fibrillation: The Fushimi AF Registry.
Conclusions: In our community-based prospective cohort, Japanese extreme elderly AF patients had a higher incidence of stroke but similar major bleeding risks compared with the younger AF population. Trial Registry: UMIN Clinical Trials Registry; No.: UMIN000005834; URL: http://www.umin.ac.jp/ctr/index.htm. PMID: 26181726 [PubMed - as supplied by publisher]
Source: Chest - July 16, 2015 Category: Respiratory Medicine Authors: Yamashita Y, Hamatani Y, Esato M, Chun YH, Tsuji H, Wada H, Hasegawa K, Abe M, Lip GY, Akao M Tags: Chest Source Type: research

Assessment and comparison of CHADS2, CHA2DS2-VASc, and HAS-BLED scores in patients with atrial fibrillation in Saudi Arabia
Conclusions: The results of this study show that the percentage of patients at high risk for stroke and bleeding is very high. The study revealed that this could be attributed to the high prevalence of modifiable risk factors for stroke and for bleeding in Saudi patients with AF.
Source: Annals of Thoracic Medicine - April 10, 2016 Category: Respiratory Medicine Authors: Abdulrahman M Al-TuraikiMaha A Al-AmmariShmeylan A Al-HarbiNabil S KhalidiAbdulmalik M AlkatheriTariq M AldebasiSalah M AbuRuzAbdulkareem M Albekairy Source Type: research

Comparing the Effectiveness and Safety of Non-Vitamin K Antagonist Oral Anticoagulants and Warfarin in the Elderly Asian Patients with Atrial Fibrillation: A Nationwide Cohort Study.
CONCLUSIONS: Compared to warfarin, NOACs were associated with a significantly lower risk of adverse events, with heterogeneity in treatment effects among different age strata. Overall, the clear safety signal in favor of NOACs over warfarin was evident irrespective of age strata, being most marked in the most elderly. PMID: 31809694 [PubMed - as supplied by publisher]
Source: Chest - December 2, 2019 Category: Respiratory Medicine Authors: Chao TF, Chiang CE, Liao JN, Chen TJ, Lip GYH, Chen SA Tags: Chest Source Type: research