Major Bleeding and Hemorrhagic Stroke with Direct Oral Anticoagulants in Patients with Renal Failure: Systematic Review and Meta-Analysis of Randomized Trials.

CONCLUSIONS: As a class, DOACs are associated with reduced risk for hemorrhagic stroke in patients with RF compared to VKA. However, DOACs may differ from each other in their relative risk for major bleeding in patients with eCrCL <50mL/min. PMID: 26836922 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26836922?dopt=Abstract

Source: Chest - January 18, 2016 Category: Respiratory Medicine Authors: Raccah BH, Perlman A, Danenberg HD, Pollak A, Muszkat M, Matok I Tags: Chest Source Type: research