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Efficacy and Safety of Platelet Glycoprotein Receptor Blockade in Aged and Comorbid Mice With Acute Experimental Stroke Basic Sciences
Conclusions— Inhibition of early steps of thrombus formation protects adult and comorbid mice from ischemic stroke. The use of clinically meaningful mouse strains might improve the translation of preclinical stroke research to the clinic.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Kraft, P., Schuhmann, M. K., Fluri, F., Lorenz, K., Zernecke, A., Stoll, G., Nieswandt, B., Kleinschnitz, C. Tags: Animal Models of Human Disease, Hypertension, Treatment, Ischemic Stroke, Atherosclerosis Basic Sciences Source Type: research

Relationship of Age With Stroke and Death in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: AMADEUS Trial Clinical Sciences
Conclusions— Elderly patients with atrial fibrillation have higher absolute risks of cardiovascular death, SSE, and bleeding, but relative risks of clinically relevant bleeding are not significantly different with increasing age strata. A significant inverse relationship between time in therapeutic range and bleeding and cardiovascular death/SSE emphasizes the importance of good quality anticoagulation control.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Senoo, K., Lip, G. Y. H. Tags: Coumarins, Anticoagulants Clinical Sciences Source Type: research

Clinical and Economic Implications of Apixaban Versus Aspirin in the Low-Risk Nonvalvular Atrial Fibrillation Patients Clinical Sciences
Conclusions— Anticoagulant treatment with apixaban versus aspirin in low-risk patients, as identified using CHADS2 or CHA2DS2–VASc, is projected to increase life expectancy and provide clinical benefits that are cost effective.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Lip, G. Y. H., Lanitis, T., Mardekian, J., Kongnakorn, T., Phatak, H., Dorian, P. Tags: Primary prevention, Cerebrovascular disease/stroke, Anticoagulants, Antiplatelets Clinical Sciences Source Type: research

The Heidelberg Bleeding Classification: Classification of Bleeding Events After Ischemic Stroke and Reperfusion Therapy Comments and Opinions
Source: Stroke - September 28, 2015 Category: Neurology Authors: von Kummer, R., Broderick, J. P., Campbell, B. C. V., Demchuk, A., Goyal, M., Hill, M. D., Treurniet, K. M., Majoie, C. B. L. M., Marquering, H. A., Mazya, M. V., Roman, L. S., Saver, J. L., Strbian, D., Whiteley, W., Hacke, W. Tags: Acute Cerebral Hemorrhage, Intracerebral Hemorrhage, Thrombolysis, Other Stroke Treatment - Surgical Comments and Opinions Source Type: research

Cavernous Sinus Thrombosis in Children: Imaging Characteristics and Clinical Outcomes Brief Reports
Conclusions— CAN and infarcts were common in this modest cohort of children with CST. Despite the high incidence of CAN and infarction, outcomes were often favorable. Although this is the largest cohort of childhood CST reported to date, large multicenter cohorts are needed to confirm our findings and determine the preferred therapeutic strategies for childhood CST.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Press, C. A., Lindsay, A., Stence, N. V., Fenton, L. Z., Bernard, T. J., Mirsky, D. M. Tags: Computerized tomography and Magnetic Resonance Imaging, Anticoagulants, Antiplatelets Brief Reports Source Type: research

Rate of Contrast Extravasation on Computed Tomographic Angiography Predicts Hematoma Expansion and Mortality in Primary Intracerebral Hemorrhage Clinical Sciences
Conclusions— Contrast extravasation rate, or spot sign growth, further refines the ability to predict hematoma expansion and mortality. Our results support the hypothesis that the spot sign directly measures active bleeding in acute intracerebral hemorrhage.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Brouwers, H. B., Battey, T. W. K., Musial, H. H., Ciura, V. A., Falcone, G. J., Ayres, A. M., Vashkevich, A., Schwab, K., Viswanathan, A., Anderson, C. D., Greenberg, S. M., Pomerantz, S. R., Ortiz, C. J., Goldstein, J. N., Gonzalez, R. G., Rosand, J., Ro Tags: Acute Cerebral Hemorrhage, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention in Asian Patients With Nonvalvular Atrial Fibrillation: Meta-Analysis Clinical Sciences
Conclusions— Our findings suggest that standard-dose NOACs were more effective and safer in Asians than in non-Asians, whereas low-dose NOACs performed similarly in both populations.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Wang, K.-L., Lip, G. Y. H., Lin, S.-J., Chiang, C.-E. Tags: Other anticoagulants, Anticoagulants Clinical Sciences Source Type: research

Antithrombotic Treatment Following Intracerebral Hemorrhage in Patients With and Without Atrial Fibrillation Clinical Sciences
Conclusions— In majority of patients who receive antithrombotic agents, treatment is initiated within 6 months of ICH. Still, many patients with compelling indications for antithrombotic treatment are not prescribed antithrombotic agents. Factors other than high risk of embolic stroke by CHA2DS2-VASc in ICH survivors with concurrent AF are used to guide the anticoagulant treatment decision in Swedish clinical practice.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Pennlert, J., Asplund, K., Carlberg, B., Wiklund, P.-G., Wisten, A., Asberg, S., Eriksson, M. Tags: Acute Cerebral Hemorrhage, Anticoagulants, Antiplatelets, Epidemiology Clinical Sciences Source Type: research

White Matter Lesions Double the Risk of Post-Thrombolytic Intracerebral Hemorrhage Clinical Sciences
Conclusions— WMLs visible on computed tomography are associated with a more than doubled risk of sICH in patients treated with intravenous thrombolysis for acute ischemic stroke.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Curtze, S., Haapaniemi, E., Melkas, S., Mustanoja, S., Putaala, J., Sairanen, T., Sibolt, G., Tiainen, M., Tatlisumak, T., Strbian, D. Tags: Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research

Duration of Diabetes Mellitus and Risk of Thromboembolism and Bleeding in Atrial Fibrillation: Nationwide Cohort Study Clinical Sciences
Conclusions— In patients with atrial fibrillation, longer duration of diabetes mellitus was associated with a higher risk of thromboembolism, but not with a higher risk of anticoagulant-related bleeding. Considering the critical balance between preventing thromboembolism and avoiding bleeding, longer duration of diabetes mellitus may favor initiation of anticoagulant therapy.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Overvad, T. F., Skjoth, F., Lip, G. Y. H., Lane, D. A., Albertsen, I. E., Rasmussen, L. H., Larsen, T. B. Tags: Thrombosis risk factors, Type 1 diabetes, Type 2 diabetes, Embolic stroke, Anticoagulants Clinical Sciences Source Type: research

Early Recurrence and Cerebral Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation: Effect of Anticoagulation and Its Timing: The RAF Study Clinical Sciences
Conclusions— Acute stroke in atrial fibrillation patients is associated with high rates of ischemic recurrence and major bleeding at 90 days. This study has observed that high CHA2DS2-VASc score, high National Institutes of Health Stroke Scale, large ischemic lesions, and type of anticoagulant administered each independently led to a greater risk of recurrence and bleedings. Also, data showed that the best time for initiating anticoagulation treatment for secondary stroke prevention is 4 to 14 days from stroke onset. Moreover, patients treated with oral anticoagulants alone had better outcomes compared with patients ...
Source: Stroke - July 27, 2015 Category: Neurology Authors: Paciaroni, M., Agnelli, G., Falocci, N., Caso, V., Becattini, C., Marcheselli, S., Rueckert, C., Pezzini, A., Poli, L., Padovani, A., Csiba, L., Szabo, L., Sohn, S.-I., Tassinari, T., Abdul-Rahim, A. H., Michel, P., Cordier, M., Vanacker, P., Remillard, S Tags: Coumarins Clinical Sciences Source Type: research

Acute Reperfusion Therapy and Stroke Care in Asia After Successful Endovascular Trials Understanding and Applying the Endovascular Trials
The current status of and prospects for acute stroke care in Asia in the situation where both intravenous thrombolysis and endovascular therapies have been recognized as established strategies for acute stroke are reviewed. Of 15 million people annually having stroke worldwide, 9 million are Asians. The burdens of both ischemic and hemorrhagic strokes are severe in Asia. The unique features of stroke in Asia include susceptibility to intracranial atherosclerosis, high prevalence of intracerebral hemorrhage, effects of dietary and lifestyle habits, and several disorders with genetic causes. These features affect acute strok...
Source: Stroke - May 22, 2015 Category: Neurology Authors: Toyoda, K., Koga, M., Hayakawa, M., Yamagami, H. Tags: Emergency treatment of Stroke, Anticoagulants, Thrombolysis, Angioplasty and Stenting Understanding and Applying the Endovascular Trials Source Type: research

Natural History and Management of Basilar Trunk Artery Aneurysms Clinical Sciences
Conclusions— BTAs natural histories may differ depending on subtype of aneurysm. Saccular aneurysms likely represent an underlying predisposition to aneurysm development because more than half of these cases were associated with multiple intracranial aneurysms. Intervention should be considered in segmental ectasia and chronic dissecting aneurysms, which demonstrate increase in size over time as there is an increased risk of subarachnoid hemorrhage.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Saliou, G., Sacho, R. H., Power, S., Kostynskyy, A., Willinsky, R. A., Tymianski, M., terBrugge, K. G., Rawal, S., Krings, T. Tags: Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Aneurysm, AVM, hematoma Clinical Sciences Source Type: research

Effect of Decompressive Craniectomy on Outcome Following Subarachnoid Hemorrhage in Mice Basic Sciences
Conclusions— Performing DC to reduce ICP either during or acutely after SAH resulted in more severe bleeding, a higher incidence of rebleeding, and poorer outcome. Thus, elevated post-hemorrhagic ICP plays an important role in controlling bleeding after SAH and should therefore not be reduced acutely. If DC is considered for treating a patient with SAH, the timing of decompression should take these effects into consideration.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Buhler, D., Azghandi, S., Schuller, K., Plesnila, N. Tags: Animal models of human disease, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Other Stroke Treatment - Surgical Basic Sciences Source Type: research

17{beta}-Estradiol Attenuates Hematoma Expansion Through Estrogen Receptor {alpha}/Silent Information Regulator 1/Nuclear Factor-kappa B Pathway in Hyperglycemic Intracerebral Hemorrhage Mice Basic Sciences
Conclusions— E2 treatment prevented hyperglycemia-enhanced HE and improved neurological deficits in ICH mice mediated by ERα/Sirt1/nuclear factor-kappa B pathway. E2 may serve as an alternative treatment to decrease early HE after ICH.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Zheng, Y., Hu, Q., Manaenko, A., Zhang, Y., Peng, Y., Xu, L., Tang, J., Tang, J., Zhang, J. H. Tags: Animal models of human disease, Neuroprotectors Basic Sciences Source Type: research

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