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Source: Stroke
Condition: Bleeding

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Total 101 results found since Jan 2013.

Classification of Bleeding Events Brief Report
Conclusions—Classification of ICH by ECASS III and HBC criteria show distinct differences. These differences warrant special attention during interpretation and comparison of scientific publications.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Ulf Neuberger, Markus Alfred Mohlenbruch, Christian Herweh, Christian Ulfert, Martin Bendszus, Johannes Pfaff Tags: Cerebrovascular Procedures, Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research

Toll-Like Receptor 4 Mediates Hemorrhagic Transformation After Delayed Tissue Plasminogen Activator Administration in In Situ Thromboembolic Stroke Brief Report
Conclusions—Our results demonstrate TLR4 involvement in hemorrhagic transformation induced by delayed tPA administration, very likely by increasing matrix metalloproteinase 9 expression.
Source: Stroke - May 22, 2017 Category: Neurology Authors: Alicia Garcia–Culebras, Sara Palma–Tortosa, Ana Moraga, Isaac Garcia–Yebenes, Violeta Duran–Laforet, Maria I. Cuartero, Juan de la Parra, Ana L. Barrios–Munoz, Jaime Diaz–Guzman, Jesus M. Pradillo, Maria A. Moro, Ignaci Tags: Blood-Brain Barrier, Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research

Benefits of Emergency Departments’ Contribution to Stroke Prophylaxis in Atrial Fibrillation Clinical Sciences
Conclusions—Prescription of anticoagulation in the ED does not increase bleeding risk in atrial fibrillation patients at high risk of stroke and contributes to decreased mortality.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Blanca Coll–Vinent, Alfonso Martin, Juan Sanchez, Juan Tamargo, Coral Suero, Francisco Malagon, Mercedes Varona, Manuel Cancio, Susana Sanchez, Jose Carbaȷosa, Jose Rios, Georgina Casanovas, Carles Rafols, Carmen del Arco, on behalf of the E Tags: Arrhythmias Original Contributions Source Type: research

Using Artificial Intelligence to Reduce the Risk of Nonadherence in Patients on Anticoagulation Therapy Brief Report
Conclusions—Patients, some with little experience using a smartphone, successfully used the technology and demonstrated a 50% improvement in adherence based on plasma drug concentration levels. For patients receiving direct oral anticoagulants, absolute improvement increased to 67%. Real-time monitoring has the potential to increase adherence and change behavior, particularly in patients on direct oral anticoagulant therapy.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02599259.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Daniel L. Labovitz, Laura Shafner, Morayma Reyes Gil, Deepti Virmani, Adam Hanina Tags: Secondary Prevention, Quality and Outcomes, Ischemic Stroke Brief Reports Source Type: research

Predictors for Symptomatic Intracranial Hemorrhage After Endovascular Treatment of Acute Ischemic Stroke Clinical Sciences
Conclusions—Incidence of SICH after thrombectomy is higher in Asian patients with acute ischemic stroke. Cardioembolic stroke, poor collateral circulation, delayed endovascular treatment, multiple passes with stent retriever device, lower pretreatment Alberta Stroke Program Early Computed Tomography Score, higher baseline neutrophil ratio may increase the risk of SICH.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Yonggang Hao, Dong Yang, Huaiming Wang, Wenjie Zi, Meng Zhang, Yu Geng, Zhiming Zhou, Wei Wang, Haowen Xu, Xiguang Tian, Penghua Lv, Yuxiu Liu, Yunyun Xiong, Xinfeng Liu, Gelin Xu, for the ACTUAL Investigators (Endovascular Treatment for Acute Anterior C Tags: Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Is There an Obesity Paradox for Outcomes in Atrial Fibrillation? Clinical Sciences
Conclusions—There may be an obesity paradox in atrial fibrillation patients, particularly for all-cause and cardiovascular death outcomes. An obesity paradox was also evident for stroke/systemic embolic event outcome in NOAC trials, with a treatment effect favoring NOACs over warfarin for both efficacy and safety that was significant only for normal weight patients.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Marco Proietti, Elisa Guiducci, Paola Cheli, Gregory Y.H. Lip Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Obesity, Anticoagulants, Quality and Outcomes Original Contributions Source Type: research

Rivaroxaban Versus Dabigatran or Warfarin in Real-World Studies of Stroke Prevention in Atrial Fibrillation Clinical Sciences
Conclusions—In this systematic review and meta-analysis, rivaroxaban was as effective as dabigatran, but was more effective than warfarin for the prevention of stroke/thromboembolism in atrial fibrillation patients. Major bleeding risk was significantly higher with rivaroxaban than with dabigatran, as was all-cause mortality and gastrointestinal bleeding. Rivaroxaban was comparable to warfarin for major bleeding, with an increased risk in gastrointestinal bleeding and decreased risk of intracranial hemorrhage.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Ying Bai, Hai Deng, Alena Shantsila, Gregory Y.H. Lip Tags: Meta Analysis, Quality and Outcomes Original Contributions Source Type: research

Microsurgery for ARUBA Trial (A Randomized Trial of Unruptured Brain Arteriovenous Malformation)-Eligible Unruptured Brain Arteriovenous Malformations Clinical Sciences
Background and Purpose—The management of unruptured brain arteriovenous malformations (ubAVMs) remains controversial despite ARUBA trial (A Randomized Trial of Unruptured Brain Arteriovenous Malformation), a controlled trial that suggested superiority of conservative management over intervention. However, microsurgery occurred in only 14.9% of ARUBA intervention cases, raising concerns about the study’s generalizability. Our purpose was to evaluate whether, in a larger ARUBA-eligible ubAVM population, microsurgery produces acceptable outcomes.Methods—Demographic data, AVM characteristics, and treatment outcomes were ...
Source: Stroke - December 22, 2016 Category: Neurology Authors: Johnny Wong, Alana Slomovic, George Ibrahim, Ivan Radovanovic, Michael Tymianski Tags: Treatment, Quality and Outcomes, Cerebrovascular Malformations, Cerebrovascular Procedures Original Contributions Source Type: research

Anticoagulation Use and Clinical Outcomes After Major Bleeding on Dabigatran or Warfarin in Atrial Fibrillation Clinical Sciences
Conclusions—Dabigatran was associated with a superior benefit/risk ratio than warfarin and anticoagulation discontinuation in the treatment of atrial fibrillation patients who have survived a major bleed.
Source: Stroke - December 22, 2016 Category: Neurology Authors: Inmaculada Hernandez, Yuting Zhang, Maria M. Brooks, Paul K.L. Chin, Samir Saba Tags: Atrial Fibrillation, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Renal Function and the Risk of Stroke and Bleeding in Patients With Atrial Fibrillation Clinical Sciences
Background and Purpose—We sought to determine the risk of stroke/thromboembolism and bleeding associated with reduced renal function in patients with atrial fibrillation and the risk of stroke and bleeding associated with warfarin treatment in specific estimated glomerular filtration rate (eGFR) groups.Methods—We conducted a register-based cohort study and included patients discharged with nonvalvular atrial fibrillation from 1997 to 2011 with available eGFR.Results—A total of 17 349 patients were identified with eGFR available at baseline. All levels of lower eGFR were associated with higher risk of stroke/thrombo...
Source: Stroke - October 23, 2016 Category: Neurology Authors: Bonde, A. N., Lip, G. Y. H., Kamper, A.–L., Fosbol, E. L., Staerk, L., Carlson, N., Torp–Pedersen, C., Gislason, G., Olesen, J. B. Tags: Atrial Fibrillation Original Contributions Source Type: research

Effect of Estimated Glomerular Filtration Rate Decline on the Efficacy and Safety of Clopidogrel With Aspirin in Minor Stroke or Transient Ischemic Attack Clinical Sciences
Background and Purpose—Patients with chronic kidney disease (CKD) are at a particularly high risk for ischemic and bleeding events. Limited data exist as to the efficacy and safety of clopidogrel in stroke patients with renal dysfunction. Therefore, we sought to assess the impact of decreased kidney function on clinical outcomes for stroke patients on clopidogrel–aspirin treatment.Methods—Patients in the CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) were randomized to clopidogrel–aspirin or aspirin-alone treatment. The primary efficacy outcome was new stroke during ...
Source: Stroke - October 23, 2016 Category: Neurology Authors: Zhou, Y., Pan, Y., Wu, Y., Zhao, X., Li, H., Wang, D., Johnston, S. C., Liu, L., Wang, C., Meng, X., Wang, Y., , on behalf of the CHANCE Investigators Tags: Nephrology and Kidney, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Higher Risk of Ischemic Events in Secondary Prevention for Patients With Persistent Than Those With Paroxysmal Atrial Fibrillation Clinical Sciences
Conclusions— Among patients with previous ischemic stroke or transient ischemic attack, those with sustained AF had a higher risk of stroke or systemic embolism compared with those with paroxysmal AF. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01581502.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Koga, M., Yoshimura, S., Hasegawa, Y., Shibuya, S., Ito, Y., Matsuoka, H., Takamatsu, K., Nishiyama, K., Todo, K., Kimura, K., Furui, E., Terasaki, T., Shiokawa, Y., Kamiyama, K., Takizawa, S., Okuda, S., Okada, Y., Kameda, T., Nagakane, Y., Yagita, Y., K Tags: Atrial Fibrillation, Secondary Prevention, Quality and Outcomes Clinical Sciences Source Type: research

Letter by Iannuccelli et al Regarding Article, "Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke" Letters to the Editor
Source: Stroke - August 21, 2016 Category: Neurology Authors: Iannuccelli, C., Di Franco, M., Pulcinelli, F. M. Tags: Heart Failure, Ischemic Stroke Letters to the Editor Source Type: research

Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke: Clopidogrel Plus Aspirin Versus Aspirin Alone Clinical Sciences
Conclusions— Clopidogrel plus aspirin might not be superior to aspirin alone for preventing new ischemic lesion and clinical vascular events in patients with acute ischemic stroke caused by large artery atherosclerosis. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00814268.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Hong, K.-S., Lee, S.-H., Kim, E. G., Cho, K.-H., Chang, D. I., Rha, J.-H., Bae, H.-J., Lee, K. B., Kim, D. E., Park, J.-M., Kim, H.-Y., Cha, J.-K., Yu, K.-H., Lee, Y.-S., Lee, S. J., Choi, J. C., Cho, Y.-J., Kwon, S. U., Kim, G.-M., Sohn, S.-I., Park, K.- Tags: Ischemic Stroke Clinical Sciences Source Type: research

Remote Intracerebral Hemorrhage After Intravenous Thrombolysis: Results From a Multicenter Study Clinical Sciences
Conclusions— The occurrence of rPH after intravenous thrombolysis with recombinant tissue-type plasminogen activator in patients with ischemic stroke is associated with lobar cerebral microbleeds and multiple ischemic lesions in different regions.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Prats-Sanchez, L., Camps-Renom, P., Sotoca-Fernandez, J., Delgado-Mederos, R., Martinez-Domeno, A., Marin, R., Almendrote, M., Dorado, L., Gomis, M., Codas, J., Llull, L., Gomez Gonzalez, A., Roquer, J., Purroy, F., Gomez-Choco, M., Canovas, D., Cocho, D. Tags: Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Clinical Sciences Source Type: research