• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

BCI-activated electrical stimulation in children with perinatal stroke and hemiparesis: A pilot study
ConclusionBrain computer interface-FES was well -tolerated and feasible in children with hemiparesis. This paves the way for clinical trials to optimize approaches and test efficacy.
Source: Frontiers in Human Neuroscience - March 17, 2023 Category: Neuroscience Source Type: research

Laterality Index Calculations in a Control Study of Functional Near Infrared Spectroscopy
In conclusion, both analysis pipelines were able to correctly determine brain laterality, but processes to account for negative beta values were recommended especially when utilizing the GLM analysis to determine brain laterality.PMID:36757503 | DOI:10.1007/s10548-023-00942-3
Source: Brain Topography - February 9, 2023 Category: Neuroscience Authors: Jordan A Borrell Kaitlin Fraser Arun Karumattu Manattu Jorge M Zuniga Source Type: research

Electric field simulations of transcranial direct current stimulation in children with perinatal stroke
DiscussionIndividualized patient-centered tDCS EF simulations are prudent for clinical trial planning and may provide insight into the efficacy of tDCS interventions in children with PS.
Source: Frontiers in Human Neuroscience - February 2, 2023 Category: Neuroscience Source Type: research

Application of the Gait Deviation Index to Study Gait Impairment in Adult Population With Spinal Cord Injury: Comparison With the Walking Index for Spinal Cord Injury Levels
The Gait Deviation Index (GDI) is a multivariate measure of overall gait pathology based on 15 gait features derived from three-dimensional (3D) kinematic data. GDI aims at providing a comprehensive, easy to interpret, and clinically meaningful metric of overall gait function. It has been used as an outcome measure to study gait in several conditions: cerebral palsy (CP), post-stroke hemiparetic gait, Duchenne muscular dystrophy, and Parkinson’s disease, among others. Nevertheless, its use in population with Spinal Cord Injury (SCI) has not been studied yet. The aim of the present study was to investigate the applicabili...
Source: Frontiers in Human Neuroscience - April 4, 2022 Category: Neuroscience Source Type: research

Prediction of Communication Impairment in Children With Bilateral Cerebral Palsy Using Multivariate Lesion- and Connectome-Based Approaches: Protocol for a Multicenter Prospective Cohort Study
DiscussionThe findings of the study may lead to the development of several translational tools that can individually predict communication impairment in children newly diagnosed with BCP to ensure that these children receive early, targeted therapeutic intervention before they begin school.Trial registrationThe study has been registered with the Chinese Clinical Trial Registry (ChiCTR2100049497).
Source: Frontiers in Human Neuroscience - January 31, 2022 Category: Neuroscience Source Type: research

Targeting Complement C3a Receptor to Improve Outcome After Ischemic Brain Injury
Neurochem Res. 2021 Aug 11. doi: 10.1007/s11064-021-03419-6. Online ahead of print.ABSTRACTIschemic stroke is a major cause of disability. No efficient therapy is currently available, except for the removal of the occluding blood clot during the first hours after symptom onset. Loss of function after stroke is due to cell death in the infarcted tissue, cell dysfunction in the peri-infarct region, as well as dysfunction and neurodegeneration in remote brain areas. Plasticity responses in spared brain regions are a major contributor to functional recovery, while secondary neurodegeneration in remote regions is associated wit...
Source: Neurochemical Research - August 11, 2021 Category: Neuroscience Authors: Marcela Pekna Anna Stokowska Milos Pekny Source Type: research

High-Dose Prednisolone for Treatment of Infantile Spasms After Presumed Perinatal Stroke
CONCLUSION: This case suggests high-dose prednisolone could be considered for first-line therapy for children with infantile spasms due to perinatal stroke; further study is needed.
Source: Journal of Neuroscience Nursing - March 11, 2021 Category: Neuroscience Tags: Case Study Source Type: research

The Upper Extremity Flexion Synergy Is Minimally Expressed in Young Individuals With Unilateral Cerebral Palsy Following an Early Brain Injury
This study uses kinematics of a ballistic reaching task to evaluate the expression of the flexion synergy in individuals with pediatric hemiplegia (PH) ages six to seventeen years. Fifteen individuals with brain injuries before birth (n = 8) and around full-term (n = 7) and nine age-matched controls with no known neurological impairment completed a set of reaches in an admittance controlled robotic device. Descending drive, and the possible expression of the upper extremity flexion synergy, was modulated by increasing shoulder abduction loading. Individuals with early-onset PH achieved lower peak velocities when reaching w...
Source: Frontiers in Human Neuroscience - October 16, 2020 Category: Neuroscience Source Type: research

Is the Blood Oxygenation Level-Dependent fMRI Response to Motor Tasks Altered in Children After Neonatal Stroke?
Functional MRI is increasingly being used in the assessment of brain activation and connectivity following stroke. Many of these studies rely on the Blood Oxygenation Level Dependent (BOLD) contrast. However, the stability, as well as the accuracy of the BOLD response to motor task in the ipsilesional hemisphere, remains ambiguous. In this work, the BOLD signal acquired from both healthy and affected hemispheres was analyzed in 7-year-old children who sustained a Neonatal Arterial Ischemic Stroke (NAIS). Accordingly, a repetitive motor task of the contralesional and the ipsilesional hands was performed by 33 patients with ...
Source: Frontiers in Human Neuroscience - April 28, 2020 Category: Neuroscience Source Type: research

Simulating Hemiparetic Gait in Healthy Subjects Using TPAD With a Closed-Loop Controller
Hemiparetic gait is abnormal asymmetric walking, often observed among patients with cerebral palsy or stroke. One of the major features of asymmetric gait is excessive reliance on the healthy leg, which results in improper load shift, slow walking speed, higher metabolic cost, and weakness of the unused leg. Hence, clinically it is desirable to promote gait symmetry to improve walking. While there are no clear methods to achieve this goal, we are exploring new methods where we guide the pelvis to change the gait symmetry. This controller is designed to mimic the hands of a physical therapist holding the pelvis and guiding ...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - April 30, 2019 Category: Neuroscience Source Type: research

Muscle Synergies During Repetitive Stoop Lifting With a Bioelectrically-Controlled Lumbar Support Exoskeleton
Conclusions Our current study aims to examine the effects of a lumbar support exoskeleton from the perspective of muscle coordination with muscle synergy analysis. For our experimental protocol, we assumed a fixed spatial set of muscle synergy weights, but variable recruitment (timing coefficients) for each condition. Chvatal and Ting (2012) provided evidence in their results and cited a multitude of studies that strongly support the assumption that modifications in human walking can be attributed to variances in the recruitment of spatially-fixed muscle synergies. Our results indicate that muscle coordination patterns a...
Source: Frontiers in Human Neuroscience - April 29, 2019 Category: Neuroscience Source Type: research

Pages: 1  2  3