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Condition: Alzheimer's
Procedure: Transplants
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Total 42 results found since Jan 2013.
Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Future Directions
This article summarizes the current knowledge about clonal hematopoiesis of indeterminate potential (CHIP), its association with cardiovascular disease (CVD), and other outcomes, pathogenesis, postulated mechanisms of various pathologies, current knowledge gaps, possible targets of intervention, and therapeutic implications.Recent FindingsRecently, a common age-related hematological entity known as CHIP has been identified as the independent risk factor for CVD. CHIP is defined as the presence of clonally expanded blood cells involving leukemogenic mutations without the evidence of malignancy. CHIP is known to increase the...
Source: Current Oncology Reports - March 16, 2023 Category: Cancer & Oncology Source Type: research
The Therapeutic Potential of Mitochondria Transplantation Therapy in Neurodegenerative and Neurovascular Disorders
Curr Neuropharmacol. 2022 Sep 8. doi: 10.2174/1570159X05666220908100545. Online ahead of print.ABSTRACTNeurodegenerative and neurovascular disorders affect millions of people worldwide and account for a large and increasing health burden on the general population. Thus, there is a critical need to identify potential disease-modifying treatments that can prevent or slow the disease progression. Mitochondria are highly dynamic organelles and play an important role in energy metabolism and redox homeostasis, and mitochondrial dysfunction threatens cell homeostasis, perturbs energy production, and ultimately leads to cell deat...
Source: Current Neuropharmacology - September 12, 2022 Category: Drugs & Pharmacology Authors: Mohammad Moshahid Khan Hector G Paez Christopher R Pitzer Stephen E Alway Source Type: research
Therapeutic Potential of Astrocyte Transplantation
Cell Transplant. 2022 Jan-Dec;31:9636897221105499. doi: 10.1177/09636897221105499.ABSTRACTCell transplantation is an attractive treatment strategy for a variety of brain disorders, as it promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of astrocytes has come into light recently as a therapy for amyotrophic lateral sclerosis (ALS); moreover, grafting of astrocytes also showed positive results in models of other conditions ranging from neurodegenerative diseases of older age to traumatic injury and stroke. Despite clear differences in etiology, disorders such as ALS, Parkinson's, ...
Source: Cell Transplantation - June 30, 2022 Category: Cytology Authors: Nataly Hastings Wei-Li Kuan Andrew Osborne Mark R N Kotter Source Type: research
Exploring the role of stem cell therapy in treating neurodegenerative diseases: Challenges and current perspectives
Curr Stem Cell Res Ther. 2021 Aug 9. doi: 10.2174/1574888X16666210810103838. Online ahead of print.ABSTRACTSeveral human neurological disorders such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis; Huntington's disease, spinal cord injury, multiple sclerosis, and brain stroke, are caused by the injury to neurons or glial cells. The recent years have witnessed the successful generation of neurons and glia cells driving efforts to develop stem-cell-based therapies for patients to combat a broad spectrum of human neurological diseases. The inadequacy of suitable cell types for cell replacement thera...
Source: Current Stem Cell Research and Therapy - February 9, 2022 Category: Stem Cells Authors: Nidhi Puranik Ananta Prasad Arukha Shiv Kumar Yadav Dhananjay Yadav Jun O Jin Source Type: research
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Clin Microbiol Rev. 2022 Jan 5;35(1):e0033820. doi: 10.1128/CMR.00338-20. Online ahead of print.ABSTRACTThe human body is full of an extensive number of commensal microbes, consisting of bacteria, viruses, and fungi, collectively termed the human microbiome. The initial acquisition of microbiota occurs from both the external and maternal environments, and the vast majority of them colonize the gastrointestinal tract (GIT). These microbial communities play a central role in the maturation and development of the immune system, the central nervous system, and the GIT system and are also responsible for essential metabolic pat...
Source: Clinical Microbiology Reviews - January 5, 2022 Category: Microbiology Authors: Shokufeh Ghasemian Sorboni Hanieh Shakeri Moghaddam Reza Jafarzadeh-Esfehani Saman Soleimanpour Source Type: research
