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Evaluation of targeted oxidative stress induced by oxygen-ozone < em > in vitro < /em > after ischemic induction
Redox Rep. 2022 Dec;27(1):259-269. doi: 10.1080/13510002.2022.2143104.ABSTRACTEncephalic vascular accident, or stroke, is the most common pathology of the central nervous system in humans, the second leading cause of death and physical and cognitive disabilities, in developing countries. It presents as an ischemic (more common) or hemorrhagic form. Ozone therapy has been shown to be effective in neuromodulation, neuroprotection, and nerve regeneration. The present study aimed to evaluate the effect of targeted mild ozone after inducing cerebral ischemia in vitro. Neuroblastoma lineage cells (SH-SY5Y) and canine amniotic me...
Source: Redox Report : communications in free radical research - November 10, 2022 Category: Biochemistry Authors: Jessica Rodrigues Orlandin Sarah Ingrid Pinto Santos Luciana Cristina Machado Paulo Fantinato Neto Fabiana Fernandes Bressan Naira Caroline Godoy Pieri Kaiana Recchia Meline de Paula Coutinho Priscilla Avelino Ferreira Pinto Annalisa Santucci Valter Trava Source Type: research

Increase of Cry 1 expression is a common phenomenon of the disturbed circadian clock in ischemic stroke and opioid addiction
Biochem Biophys Res Commun. 2021 Apr 21;558:8-13. doi: 10.1016/j.bbrc.2021.04.053. Online ahead of print.ABSTRACTIncreasing evidences suggest the involvement of disrupted circadian clock in various pathologies including stroke and substance abuse. Here we took an attempt to do a comparative study on the regulation of circadian clock gene expression under two pathological circumstances - Opioid addiction and Ischemic stroke in the same cell line model (human neuroblastoma SH-SY5Y cells). To mimic in vivo ischemic stroke condition cells were placed in a hypoxia chamber and incubated for 10 h in balanced salt solution lacking...
Source: Biochemical and Biophysical Research communications - April 24, 2021 Category: Biochemistry Authors: Kaninika Roy Daytee Maji Ishani Deb Source Type: research

Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death.
lanas A, Roquer J, Valverde MA, Muñoz FJ Abstract Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its correct management. Ischemia produces increased nitric oxide synthesis to recover blood flow but also induces a free radical burst. Nitric oxide and superoxide anion react to generate peroxynitrite that nitrates tyrosines. We found that fibrinogen nitrotyrosination was detected in plasma after the initiation of ischemic stroke in human patients. Electron microscopy and protein intrinsic fluorescence showed that...
Source: Biochimica et Biophysica Acta - December 12, 2014 Category: Biochemistry Authors: Ill-Raga G, Palomer E, Ramos-Fernández E, Guix FX, Bosch-Morató M, Guivernau B, Tajes M, Valls-Comamala V, Jiménez-Conde J, Ois A, Pérez-Asensio F, Reyes-Navarro M, Caballo C, Gil-Gómez G, López-Vílchez I, Galán AM, Alameda F, Escolar G, Opazo C, Tags: Biochim Biophys Acta Source Type: research

CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation.
In this study, we showed that CIIA suppressed neuronal cell death induced by oxygen and glucose deprivation followed by reoxygenation (OGD/R), which mimics ischemia and reperfusion in vivo, in neuroblastoma cell lines as well as primary cortical neurons. Furthermore, CIIA inhibited the OGD/R-induced stimulation of apoptosis signal-regulating kinase 1 (ASK1) and its downstream kinases including c-Jun amino-terminal kinase and p38 kinase, concomitantly blocking ASK1 homo-oligomerization and the binding between ASK1 and TRAF2. CIIA also repressed the OGD/R-induced activation of caspase-3 in neuronal cells. Taken together, our...
Source: Molecular and Cellular Biochemistry - August 7, 2014 Category: Biochemistry Authors: Hwang SG, Shim J, Choi EJ Tags: Mol Cell Biochem Source Type: research

Nogo-A couples with Apg-1 through interaction and coordinate expression under hypoxic and oxidative stress
Nogo-A is the largest isoform of the Nogo/RTN4 proteins and has been characterized as a major myelin associated inhibitor of regenerative nerve growth in the adult central nervous system (CNS). Apart from the myelin sheath, Nogo-A is expressed at high levels in principal neurons of the CNS. The specificity of Nogo-A resides in its central domain, NiG. We identified Apg-1, a member of the stress induced Hsp110 family, as a novel interactor of NiG/Nogo-A. The interaction is selective because Apg-1 interacts with Nogo-A/RTN4-A but not with RTN1-A, the closest paralog of Nogo-A. Conversely, Nogo-A binds to Apg-1 but not to Apg...
Source: BJ Cell - August 2, 2013 Category: Biochemistry Authors: F Kern, R I. Stanika, B Sarg, M Offterdinger, D Hess, G J. Obermair, H Lindner, C E. Bandtlow, L Hengst, R Schweigreiter Tags: BJ Biomolecules Source Type: research