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Total 222 results found since Jan 2013.

Risk of New‐onset Diabetes after Androgen Deprivation Therapy for Prostate Cancer in the Asian Population
ConclusionsThere was increased risk of new‐onset DM after ADT for prostate cancer in the Asian population. Regular screening of DM can be considered after the initiation of ADT, especially in patients with known history of dyslipidemia and impaired fasting glucose.
Source: Journal of Diabetes - September 1, 2014 Category: Endocrinology Authors: Jeremy Yuen Chun Teoh, Peter Ka Fung Chiu, Samson Yun Sang Chan, Darren Ming Chun Poon, Ho‐Yuen Cheung, Simon See Ming Hou, Chi‐Fai Ng Tags: Original Article Source Type: research

Green tea compound may improve cancer drugs
Conclusion This study developed a new way of packaging and carrying protein drugs by combining them with a green tea extract called Epigallocatechin-3-O-gallate (EGCG), which itself may have anti-cancer properties. They formed a complex between derivatives of EGCG and the protein cancer drug Herceptin. Tests in the laboratory and in mice indicated it might have better anti-cancer properties than non-complexed free Herceptin. This is encouraging research and may lead to improvements in delivery mechanisms for protein drugs further down the line. But this research remains at a very early stage of development. The results f...
Source: NHS News Feed - October 6, 2014 Category: Consumer Health News Tags: Cancer Medication Source Type: news

Risk of Acute Myocardial Infarction after Androgen Deprivation Therapy for Prostate Cancer in the Chinese Population
Conclusions‐ There was increased risk of AMI after ADT for prostate cancer in the Chinese population.‐ Hyperlipidemia and poor ECOG performance status were also significant risk factors for developing AMI.‐ The risk of AMI should be considered while deciding on ADT, especially in patients with history of hyperlipidemia and relatively poor ECOG performance status.Prostate cancer, androgen deprivation therapy, myocardial infarction, Asian population
Source: BJU International - October 18, 2014 Category: Urology & Nephrology Authors: Jeremy Yuen Chun Teoh, Samson Yun Sang Chan, Peter Ka Fung Chiu, Darren Ming Chun Poon, Ho Yuen Cheung, Simon See Ming Hou, Chi‐Fai Ng Tags: Urological Oncology Source Type: research

2014 Alzheimer's disease facts and figures
This report discusses the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care, and overall effect on caregivers and society. It also examines the impact of AD on women compared with men. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million are age 65 years or older. By mid-century, fueled in large part by the baby boom generation, the number of people living with AD in the United States is projected to grow by about 9 million. Today, someone in the country d...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 17, 2014 Category: Geriatrics Source Type: research

2013 Alzheimer's disease facts and figures
This report provides information to increase understanding of the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, health expenditures and costs of care, and effect on caregivers and society in general. It also explores the roles and unique challenges of long-distance caregivers, as well as interventions that target those challenges. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million comprise the older onset AD population. Throughout the coming decades, the baby boom ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 17, 2014 Category: Geriatrics Source Type: research

Androgen deprivation therapy and cardiovascular risk in chinese patients with nonmetastatic carcinoma of prostate.
Conclusion. ADT in Chinese patients with nonmetastatic prostate cancer with no previously documented cardiovascular disease was associated with subsequent development of cardiovascular events. PMID: 24803931 [PubMed]
Source: Journal of Oncology - November 17, 2014 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Abstract A12: Cancer communication in African American churches
Conclusion: Cancer was a frequent topic for disease-focused messages in African-American churches. In addition, three of the five most frequent disease topics matched the leading causes of death in the African-American community. The match was not as close in regards to leading causes of cancer death. Breast and prostate cancer information was frequently found; however, despite the high rates of mortality associated with lung cancer, colorectal cancer, and leukemia/lymphoma, information on these cancers was present much less frequently. No pancreatic cancer messages were found. Disease related information was seen that inc...
Source: Cancer Epidemiology Biomarkers and Prevention - November 13, 2014 Category: Cancer & Oncology Authors: Harmon, B. E., Chastain, E., Chock, M., Wirth, M., Hebert, J. R. Tags: Cancer Communications: Poster Presentations - Proffered Abstracts Source Type: research

Risk of cardiovascular thrombotic events after surgical castration versus gonadotropin-releasing hormone agonists in Chinese men with prostate cancer.
In conclusion, SC was associated with increased risk of cardiovascular thrombotic events when compared to GnRHa. This is an important aspect to consider while deciding on the method of androgen deprivation therapy, especially in elderly men with known history of hyperlipidemia. PMID: 25578930 [PubMed - as supplied by publisher]
Source: Asian Journal of Andrology - December 23, 2014 Category: Urology & Nephrology Authors: Teoh JY, Chan SY, Chiu PK, Poon DM, Cheung HY, Hou SS, Ng CF Tags: Asian J Androl Source Type: research

Smoking Causes More Kinds Of Deaths Than We Ever Thought
Breast cancer, prostate cancer, and even routine infections. A new report ties these and other maladies to smoking and says an additional 60,000 to 120,000 deaths each year in the United States are probably due to tobacco use. The study by the American Cancer Society and several universities, published in Thursday's New England Journal of Medicine, looks beyond lung cancer, heart disease and other conditions already tied to smoking, and the 480,000 U.S. deaths attributed to them each year. "Smokers die, on average, more than a decade before nonsmokers," and in the U.S., smoking accounts for one of every five deaths, Dr. ...
Source: Science - The Huffington Post - February 12, 2015 Category: Science Source Type: news

Risk of acute myocardial infarction after androgen‐deprivation therapy for prostate cancer in a Chinese population
ConclusionsThere was increased risk of AMI after ADT for prostate cancer in a Chinese population. Hyperlipidaemia and poor ECOG PS were also significant risk factors for developing AMI. The risk of AMI should be considered when deciding on ADT, especially in patients with history of hyperlipidaemia and relatively poor ECOG PS.
Source: BJU International - March 7, 2015 Category: Urology & Nephrology Authors: Jeremy Y.C. Teoh, Samson Y.S. Chan, Peter K.F. Chiu, Darren M.C. Poon, Ho‐Yuen Cheung, Simon S.M. Hou, Chi‐Fai Ng Tags: Original Article Source Type: research

2015 Alzheimer's disease facts and figures
This report discusses the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care and the overall effect on caregivers and society. It also examines the challenges encountered by health care providers when disclosing an AD diagnosis to patients and caregivers. An estimated 5.3 million Americans have AD; 5.1 million are age ≥65 years, and approximately 200,000 are age <65 years and have younger onset AD. By mid-century, the number of people living with AD in the United States is projected to grow by nearly 10 million, fueled in large part by the aging ba...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 24, 2015 Category: Geriatrics Source Type: research

Fit middle-aged men have lower cancer risk
Conclusion This study shows that cardiovascular fitness is likely to reduce men's chances of developing lung and colorectal cancer, and appears to boost survival from cancer or cardiovascular disease in those diagnosed after the age of 65. This was based on comparing the top 40% of fittest men with the 20% least fit. The study focused on fitness and took account of major risk factors for cancer, such as smoking and blood pressure. However, it left out one important risk factor: diet. What people eat and drink is known to affect cancer risk. The fittest group may also have been the healthiest in terms of eating well and ...
Source: NHS News Feed - March 27, 2015 Category: Consumer Health News Tags: Cancer Lifestyle/exercise Source Type: news

Mp46-13 nitrone-based therapy for treatment of a murine model of human castration resistant prostate cancer
OKN-007 is a nitrone-based agent developed as an anti-oxidant to reduce stroke-related complications. However, despite making it through Phase-III trials, this nontoxic agent was not clinically effective enough to go to market. We have repurposed OKN-007 as an anticancer agent and are testing it against a murine model of human castrate resistant prostate cancer (CRPC).
Source: The Journal of Urology - April 1, 2015 Category: Urology & Nephrology Authors: Joel Slaton, Carole Davis, Nataliya Smith, Debbie Saunders, Rober Hurst, Rheal Towner Tags: Prostate Cancer: Basic Research II Source Type: research

Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases
The present review aims to ascertain whether different infertility etiologies share particular genes and/or molecular pathways with other pathologies and are associated with distinct and particular risks of later-life morbidity and mortality. In order to reach this aim, we use two different sources of information: (1) a public web server named DiseaseConnect (http://disease-connect.org) focused on the analysis of common genes and molecular mechanisms shared by diseases by integrating comprehensive omics and literature data; and (2) a literature search directed to find clinical comorbid relationships of infertility etiologi...
Source: Reproductive Biology and Endocrinology - April 15, 2015 Category: Endocrinology Authors: Juan TarínMiguel García-PérezToshio HamataniAntonio Cano Source Type: research

The Variation with Age of 67 Macro- and Microelement Contents in Nonhyperplastic Prostate Glands of Adult and Elderly Males Investigated by Nuclear Analytical and Related Methods.
Abstract To clarify age-related changes of 67 macro- and microelement contents in prostate gland of adult and geriatric males, a quantitative measurement by five analytical methods was performed. The nonhyperplastic prostate glands of 65 subjects (European-Caucasian aged 21-87 years) were investigated by energy dispersive X-ray fluorescence (EDXRF), instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides (INAA-SLR), instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides (INAA-LLR), inductively coupled plasma atomic emi...
Source: Biological Trace Element Research - May 5, 2015 Category: Biology Authors: Zaichick V Tags: Biol Trace Elem Res Source Type: research