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Total 91 results found since Jan 2013.

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Partial and complete retirement due to ill-health among mature age Australians
Conclusions: To reduce early retirement due to ill-health, health practitioners, governments and employers should address targeted health problems, particularly in areas outside capital cities.
Source: Public Health - February 20, 2013 Category: Global & Universal Authors: S.W. Pit, R. Shrestha, D. Schofield, M. Passey Tags: Original Research Source Type: research

Corrections Corrections
Traylor M, Farrall M, Holliday EG, et al, on behalf of the International Stroke Genetics Consortium. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol 2012; 11: 951–62—In this Article, the last sentence of the VISP section in the acknowledgments section should have been “Control data for comparison with VISP cases were obtained through the database of genotypes and phenotypes (dbGAP) High Density SNP Association Analysis of Melanoma: Case-Control and Outcomes Investigation (phs000187.v1.p1).
Source: Lancet Neurology - July 13, 2015 Category: Neurology Tags: Corrections Source Type: research

Risk of solid cancer, cardiovascular disease, anaphylaxis, osteoporosis and fractures in patients with systemic mastocytosis: A nationwide population‐based study
This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - July 17, 2016 Category: Hematology Authors: Sigurd Broesby‐Olsen, Dóra Körmendiné Farkas, Hanne Vestergaard, Anne Pernille Hermann, Michael Boe Møller, Charlotte Gotthard Mortz, Thomas Kielsgaard Kristensen, Carsten Bindslev‐Jensen, Henrik Toft Sørensen, Henrik Frederiksen Tags: Research Article Source Type: research

7 Foot Problems That Can Be Serious
If you want to know the state of your health, try looking down. “There’s no question it’s extremely important that people pay attention to their feet,” says Terry Philbin, D.O., spokesperson for the American Academy of Orthopedic Surgeons (AAOS) and a foot and ankle specialist at the Orthopedic Foot and Ankle Center in Westerville, Ohio. The condition of your feet can give you clues to a host of medical issues, such as diabetes, arthritis, and even heart disease. Read on to find out what to look for and what it may mean. 1. Pain “There’s no pain that should be ignored,” says Jane ...
Source: Healthy Living - The Huffington Post - November 12, 2016 Category: Consumer Health News Source Type: news

Blood Cholesterol and Outcome of Patients with Cancer under Regular Cardiological Surveillance
Curr Oncol. 2021 Feb 12;28(1):863-872. doi: 10.3390/curroncol28010085.ABSTRACTCardiovascular (CV) diseases and cancer share several similarities, including common risk factors. In the present investigation we assessed the relationship between cholesterol levels and mortality in a cardiooncological collective. In total, 551 patients receiving anticancer treatment were followed over a median of 41 (95% CI 40, 43) months and underwent regular cardiological surveillance. A total of 140 patients (25.4%) died during this period. Concomitant cardiac diseases were more common in patients who deceased (53 (37.9%) vs. 67 (16.3%), p ...
Source: Current Oncology - February 22, 2021 Category: Cancer & Oncology Authors: Anna Lena Hohneck Stephanie Rosenkaimer Ralf-Dieter Hofheinz Ibrahim Akin Martin Borggrefe Stefan Gerhards Source Type: research

Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver.
Abstract High circulating cholesterol is associated with hypercholesterolemia, atherosclerosis, and stroke. However, the relation between cholesterol and tumorigenesis/metastasis is controversial. The proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates low-density lipoprotein cholesterol homeostasis by targeting the low-density lipoprotein receptor (LDLR) for degradation. PCSK9 is mostly expressed in liver, which is one of the most common sites for metastatic disease. To reveal the function of PCSK9 and also evaluate the impact of cholesterol in liver metastasis development, B16F1 melanoma cells were i...
Source: Neoplasia - December 1, 2012 Category: Cancer & Oncology Authors: Sun X, Essalmani R, Day R, Khatib AM, Seidah NG, Prat A Tags: Neoplasia Source Type: research

Treatment Of Panx1-Related Diseases Could Involve Food Dye
The food dye Brilliant Blue FCF (BB FCF) could be a useful tool in the development of treatments for a variety of conditions involving the membrane channel protein Pannexin 1(Panx1), according to a study in The Journal of General Physiology. Panx1, which is involved in signaling events leading to inflammation and cell death, has been implicated in such diverse diseases as Crohn's, AIDS, melanoma, epilepsy, spinal cord injury, and stroke, among others. Thus, there is a demand for the development of pharmacological tools to inhibit Panx1...
Source: Health News from Medical News Today - May 1, 2013 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

Time trends of incidence of age-associated diseases in the US elderly population: medicare-based analysis
Conclusion: time trends of the incidence of diseases common in the US elderly population were evaluated. The results show dramatic increase in incidence rates of melanoma, goiter, chronic renal and Alzheimer's disease in 1992–2005. Besides specifying widely recognised time trends on age-associated diseases, new information was obtained for trends of asthma, ulcer and goiter among the older adults in the USA.
Source: Age and Ageing - June 17, 2013 Category: Geriatrics Authors: Akushevich, I., Kravchenko, J., Ukraintseva, S., Arbeev, K., Yashin, A. I. Tags: Research Papers Source Type: research

UNMC Nanotechnology Protects Skin From Cancer And Early Wrinkles
Nanotechnology developed at the University of Nebraska Medical Center could strengthen things like sunscreen and anti-aging cosmetics into more potent barriers, protecting the skin from UV radiation that can cause wrinkles and skin cancer. A new startup company, ProTransit Nanotherapy, L.L.C., was founded on the innovation, and hopes to commercialize the nontoxic, biodegradable system within the next 18 months. If successful, the nanotechnology could serve as a platform that can deliver targeted treatments to a vast range of ailments, including stroke and heart disease...
Source: Health News from Medical News Today - July 10, 2013 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Preparation of well-defined ibuprofen prodrug micelles by RAFT polymerization.
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat acute pain, fever and inflammation and are being explored in a new indication in cancer. Side effects associated with long-term use of NSAIDs such as gastrointestinal damage and elevated risk of stroke, however, can limit their use and exploration in new indications.　Here we report a facile method to prepare well-defined amphiphilic diblock copolymer NSAID prodrugs by direct reversible addition fragmentation transfer (RAFT) polymerization of the acrylamide derivative of ibuprofen (IBU), a widely used NSAID. The synthesis and self-as...
Source: Biomacromolecules - August 12, 2013 Category: Biochemistry Authors: Hasegawa U, van der Vlies AJ, Wandrey C, Hubbell JA Tags: Biomacromolecules Source Type: research

Concomitant Low Dose Doxorubicin Treatment and Exercise.
Abstract Cardiotoxicity is a common side effect for cancer patients treated with doxorubicin (DOX). We tested the hypothesis that low intensity aerobic exercise concomitant with DOX treatment would offset DOX-induced cardiotoxicity while also improving the therapeutic efficacy of DOX on tumor progression. B16F10 melanoma cells (3x10(5)) were injected subcutaneously into the scruff of 6-8 week old male C57BL/6 mice (n= 48). A 4 mg/kg cumulative dose of DOX (IP) was administered over 2 weeks (2 mg/kg, 1 day/week) and exercise (EX) consisted of treadmill walking (10 m/min, 45 min/d, 5 days/week, 2 weeks). Four experi...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - July 9, 2014 Category: Physiology Authors: Sturgeon K, Schadler K, Muthukumaran G, Ding D, Bajulaiye A, Thomas NJ, Ferrari VA, Ryeom S, Libonati JR Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Concomitant low-dose doxorubicin treatment and exercise
Cardiotoxicity is a side effect for cancer patients treated with doxorubicin (DOX). We tested the hypothesis that low-intensity aerobic exercise concomitant with DOX treatment would offset DOX-induced cardiotoxicity while also improving the therapeutic efficacy of DOX on tumor progression. B16F10 melanoma cells (3 x 105) were injected subcutaneously into the scruff of 6- to 8-wk-old male C57BL/6 mice (n = 48). A 4 mg/kg cumulative dose of DOX was administered over 2 wk, and exercise (EX) consisted of treadmill walking (10 m/min, 45 min/day, 5 days/wk, 2 wk). Four experimental groups were tested: 1) sedentary (SED) + vehicl...
Source: AJP: Regulatory, Integrative and Comparative Physiology - September 15, 2014 Category: Physiology Authors: Sturgeon, K., Schadler, K., Muthukumaran, G., Ding, D., Bajulaiye, A., Thomas, N. J., Ferrari, V., Ryeom, S., Libonati, J. R. Tags: Cardiovascular and Renal Integration Source Type: research

Talon noir: paring can eliminate the need for a biopsy
Introduction Talon noir (black heel or calcaneal petechiae) is a benign condition that appears as an asymmetric brown-black epidermal macule on the heel or elsewhere on the plantar foot. Punctate papillary dermal haemorrhages extend into the subcorneal space following shearing forces in an area of recurrent or sudden trauma.1 These lesions can mimic melanoma and haemorrhagic viral warts, especially in cases where there is no history of trauma. If the diagnosis of talon noir is considered, simple bedside tests can obviate the need for a biopsy to exclude malignant melanoma or unnecessary treatment for a presumed viral wart....
Source: Postgraduate Medical Journal - November 26, 2014 Category: Journals (General) Authors: Googe, A. B., Schulmeier, J. S., Jackson, A. R., Brodell, R. T. Tags: General practice / family medicine, Drugs: cardiovascular system, Pain (neurology), Stroke, Skin cancer, Screening (oncology), Radiology, Dermatology, Surgical diagnostic tests, General surgery, Epidemiology Images in medicine Source Type: research