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Effects of Craniopharyngioma Cyst Fluid on Neurons and Glial Cells cultured from rat brain hypothalamus
In this study, we have collected CP cyst fluid (CCF) from mostly young patients during surgical removal and exposed it 9-10 days in vitro to the primary cultures derived from rat brain hypothalamus for 48 hours. A gradual decline in cell viability was noted with increasing concentration of CCF. Moreover, a distinct degenerative morphological transformation was observed in neurons and glial cells, including appearance of blebbing and overall reduction of the cell volume. Further, enhanced expression of Caspase-3 in neurons and glial cells exposed to CCF by immunofluorescence imaging, supported by Western blot experiment s...
Source: Journal of Chemical Neuroanatomy - October 17, 2018 Category: Neuroscience Source Type: research

Relative risks of contributing factors to morbidity and mortality in adults with craniopharyngioma on GH replacement.
Conclusion: Conventional factors that increase the risks of cardio/cerebrovascular diseases and DM, and risks for developing new intra-cranial tumors contribute to the excess morbidity and mortality. Additionally, lower serum IGF-I levels measured from the last sample before death was inversely associated with mortality risk in CP patients. PMID: 29029108 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - September 29, 2017 Category: Endocrinology Authors: Yuen KCJ, Mattsson AF, Burman P, Erfurth EM, Camacho-Hubner C, Fox JL, Verhelst J, Geffner ME, Abs R Tags: J Clin Endocrinol Metab Source Type: research

The learning curve in endoscopic endonasal resection of craniopharyngiomas.
CONCLUSIONS High rates of near- or total resection and visual improvement can be achieved using an endoscopic endonasal approach for craniopharyngiomas. However, the authors did find evidence for a learning curve. After 20 cases, they found a significant decrease in major neurological complications and significant increases in the rates of GTR rate and discharge to home. Although there was a large decrease in the rate of postoperative CSF leak over time, this was largely attributable to the inclusion of very early cases prior to the routine use of vascularized nasoseptal flaps. There was a significant increase in new panhy...
Source: Neurosurgical Focus - November 30, 2016 Category: Neurosurgery Authors: Kshettry VR, Do H, Elshazly K, Farrell CJ, Nyquist G, Rosen M, Evans JJ Tags: Neurosurg Focus Source Type: research