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Mechanical thrombectomy performed in thrombosed fusiform aneurysm after surgery for craniopharyngioma in adult: Case report
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2021 Mar 31. doi: 10.5507/bp.2021.018. Online ahead of print.ABSTRACTINTRODUCTION: Fusiform dilatation of the internal carotid artery (ICA) is reported as a possible complication of craniopharyngioma resection in childhood. Here, the authors describe such a complication in an adult patient who presented with acute symptomatic thrombosis 7 months after surgery.MATERIALS AND METHODS: A 45-year-old woman presented with left hemispheric stroke due to a thrombotic supraclinoid occlusion of the terminal ICA (so called "T" occlusion). Successful revascularisation was achieved w...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - April 6, 2021 Category: Biomedical Science Authors: Pavel Ryska Miroslav Lojik Naci Kocer Kamil Zelenak Tomas Cesak Petra Cimflova Aprajita Milind Bhorkar Eva Vitkova Antonin Krajina Source Type: research

Efficacy of Direct Revascularization Surgery for Hemorrhagic Moyamoya Syndrome As a Late Complication of Cranial Irradiation for Childhood Craniopharyngioma
Moyamoya syndrome (MMS) is an uncommon late complication after cranial irradiation. Its hemorrhagic presentation from the associated pseudo-aneurysm is extremely rare, and the optimal management strategy is undetermined. We herein report a 36-year-old man who developed intraventricular hemorrhage from a pseudo-aneurysm at the extended left anterior choroidal artery as an abnormal collateral of MMS 30 years after surgical removal and cranial irradiation for childhood craniopharyngioma. Catheter angiography confirmed the diagnosis of MMS, and multiple pseudo-aneurysms were evident at the ipsilateral abnormal choroidal collat...
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Yuya Kato, Miki Fujimura, Kenichi Sato, Hidenori Endo, Teiji Tominaga Tags: Case Report Source Type: research

Effects of Craniopharyngioma Cyst Fluid on Neurons and Glial Cells cultured from rat brain hypothalamus
In this study, we have collected CP cyst fluid (CCF) from mostly young patients during surgical removal and exposed it 9-10 days in vitro to the primary cultures derived from rat brain hypothalamus for 48 hours. A gradual decline in cell viability was noted with increasing concentration of CCF. Moreover, a distinct degenerative morphological transformation was observed in neurons and glial cells, including appearance of blebbing and overall reduction of the cell volume. Further, enhanced expression of Caspase-3 in neurons and glial cells exposed to CCF by immunofluorescence imaging, supported by Western blot experiment s...
Source: Journal of Chemical Neuroanatomy - October 17, 2018 Category: Neuroscience Source Type: research

Relative risks of contributing factors to morbidity and mortality in adults with craniopharyngioma on GH replacement.
Conclusion: Conventional factors that increase the risks of cardio/cerebrovascular diseases and DM, and risks for developing new intra-cranial tumors contribute to the excess morbidity and mortality. Additionally, lower serum IGF-I levels measured from the last sample before death was inversely associated with mortality risk in CP patients. PMID: 29029108 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - September 29, 2017 Category: Endocrinology Authors: Yuen KCJ, Mattsson AF, Burman P, Erfurth EM, Camacho-Hubner C, Fox JL, Verhelst J, Geffner ME, Abs R Tags: J Clin Endocrinol Metab Source Type: research

The learning curve in endoscopic endonasal resection of craniopharyngiomas.
CONCLUSIONS High rates of near- or total resection and visual improvement can be achieved using an endoscopic endonasal approach for craniopharyngiomas. However, the authors did find evidence for a learning curve. After 20 cases, they found a significant decrease in major neurological complications and significant increases in the rates of GTR rate and discharge to home. Although there was a large decrease in the rate of postoperative CSF leak over time, this was largely attributable to the inclusion of very early cases prior to the routine use of vascularized nasoseptal flaps. There was a significant increase in new panhy...
Source: Neurosurgical Focus - November 30, 2016 Category: Neurosurgery Authors: Kshettry VR, Do H, Elshazly K, Farrell CJ, Nyquist G, Rosen M, Evans JJ Tags: Neurosurg Focus Source Type: research

A Cross‐Sectional Cohort Study of Cerebrovascular Disease and Late Effects After Radiation Therapy for Craniopharyngioma
ConclusionsPatients with craniopharyngioma treated with RT have a high prevalence of stroke and vascular abnormalities, particularly those with low HDL and longer duration of time since RT. There is a trend to suggest that continual GH replacement may reduce the risk of stroke. These patients should undergo careful monitoring and aggressive modification of stroke risk factors.
Source: Pediatric Blood and Cancer - January 12, 2016 Category: Cancer & Oncology Authors: Andrea C. Lo, A. Fuchsia Howard, Alan Nichol, Haroon Hasan, Monty Martin, Manraj Heran, Karen Goddard Tags: Research Article Source Type: research

Craniopharyngioma in Children: Long-term Outcomes.
Authors: Steinbok P Abstract The survival rate for childhood craniopharyngioma has been improving, with more long-term survivors. Unfortunately it is rare for the patient to be normal, either from the disease itself or from the effects of treatment. Long-term survivors of childhood craniopharyngioma suffer a number of impairments, which include visual loss, endocrinopathy, hypothalamic dysfunction, cerebrovascular problems, neurologic and neurocognitive dysfunction. Pituitary insufficiency is present in almost 100%. Visual and hypothalamic dysfunction is common. There is a high risk of metabolic syndrome and increa...
Source: Neurologia Medico-Chirurgica - September 9, 2015 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Symptomatic Cerebral Vasospasm and Delayed Cerebral Ischemia Following Transsphenoidal Resection of a Craniopharyngioma
Vasospasm has been rarely described as a complication associated with craniopharyngioma surgery. Herein we describe a patient who developed symptomatic vasospasm and delayed cerebral ischemia after transsphenoidal surgery for a craniopharyngioma.
Source: Journal of Stroke and Cerebrovascular Diseases - July 18, 2015 Category: Neurology Authors: Irapuá Ferreira Ricarte, Bruno F. Funchal, Maramélia A. Miranda Alves, Daniela L. Gomes, Raul A. Valiente, Flávio A. Carvalho, Gisele S. Silva Tags: Case Report Source Type: research

Endoscopic supraorbital eyebrow approach for the surgical treatment of extraaxialand intraaxial tumors.
Conclusions The endoscopic supraorbital eyebrow approach is a safe and effective minimally invasive approach to remove extra- and intraaxial anterior skull base, parasellar, and frontal lesions, promoting a rapid recovery and short hospital stay. The location of the eyebrow incision demands a meticulous cosmetic closure, but, with proper technique, cosmetic results are excellent. PMID: 25270140 [PubMed - in process]
Source: Neurosurgical Focus - October 1, 2014 Category: Neurosurgery Authors: Gazzeri R, Nishiyama Y, Ph D, Teo C Tags: Neurosurg Focus Source Type: research