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The role of plasmalemma vesicle-associated protein in pathological breakdown of blood –brain and blood–retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema
AbstractBreakdown of the blood –brain barrier (BBB) or inner blood–retinal barrier (BRB), induced by pathologically elevated levels of vascular endothelial growth factor (VEGF) or other mediators, can lead to vasogenic edema and significant clinical problems such as neuronal morbidity and mortality, or vision loss. Restoratio n of the barrier function with corticosteroids in the brain, or by blocking VEGF in the eye are currently the predominant treatment options for brain edema and diabetic macular edema, respectively. However, corticosteroids have side effects, and VEGF has important neuroprotective, vascular protect...
Source: Fluids and Barriers of the CNS - September 20, 2018 Category: Neuroscience Source Type: research

Inhaled corticosteroids may prevent lung cancer in asthma patients
CONCLUSIONS: For patients with asthma, regular ICS use might have a protective effect against LC. Further studies are required to assess this potential association from both immunohistopathological and clinical aspects.
Source: Annals of Thoracic Medicine - July 18, 2018 Category: Respiratory Medicine Authors: I-Jen Wang Wen-Miin Liang Trong-Neng Wu Wilfried J.J. Karmaus Jiin-Chyr Hsu Source Type: research

Neutrophils/Lymphocytes Ratio and Platelets/Lymphocytes Ratio and Its Relationship with Severity and Functional Prognosis in Patients with Acute Ischemic Stroke (P5.235)
CONCLUSIONS N/L ratio and P/L ratio at hospital admission have a positive correlation with the severity and functional prognosis of patients with Acute Ischemic Stroke. Due to its simple determination, affordable and safe, they could become severity and functional prognostic parameters in the initial evaluation of patients with Acute Ischemic Stroke in the future.Disclosure: Dr. Perez has nothing to disclose. Dr. Casas has nothing to disclose. Dr. Tourreilles has nothing to disclose. Dr. Gonzalez has nothing to disclose. Dr. Gimenez has nothing to disclose. Dr. Cabrera has nothing to disclose. Dr. Mattiazzi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Perez, A., Casas, S., Tourreilles, M., Gonzalez, C., Gimenez, J., Cabrera, L., Mattiazzi, M. Tags: Cerebrovascular Disease: Biomarkers Source Type: research

LATE-BREAKING ABSTRACT: Study to understand mortality and morbidIty in COPD (SUMMIT)
Chronic obstructive pulmonary disease (COPD) is recognized as having significant systemic manifestations associated with increased mortality and morbidity (Agusti, Proc Am Thorac Soc 2005;2:367-70), in particular cardiovascular (CV) disease. More patients with moderate COPD die from lung cancer and CV diseases than from COPD (Calverley, N Engl J Med 2007;356:775-89).Post-hoc analyses from the TORCH study suggest an inhaled corticosteroid/long acting beta2 agonist (ICS/LABA) combination may reduce mortality and CV events (e.g. acute coronary syndrome [ACS] and stroke) in patients with moderate COPD (≥50% predicted FEV1) ...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Vestbo, J., Anderson, J., Brook, R. D., Calverley, P., Celli, B., Crim, C., Martinez, F., Yates, J., Newby, D. Tags: 1.1 Clinical Problems Source Type: research

Clinical Outcomes of Metastatic Intra-cerebral Hemorrhage and Role of Acute Radiotherapy (P3.077)
CONCLUSIONS: Early recognition of metastatic disease as the etiology of ICH is important, particularly when it is the presenting manifestation. Despite the overall poor prognosis of metastatic cancer, early radiotherapy may increase survival and offer quality of life in selected group of patients. A larger case series is needed.Disclosure: Dr. Afzal has nothing to disclose. Dr. Mendoza has nothing to disclose. Dr. Latorre has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Afzal, U., Mendoza, M., Latorre, J. Tags: Cerebrovascular Disease and Interventional Neurology: Hemorrhagic and Ischemic Stroke Source Type: research

Acute bacterial infection negatively impacts cancer specific survival of colorectal cancer patients.
CONCLUSION: Infection and high neutrophil counts are associated with a poorer cancer-specific survival in colorectal cancer patients. PMID: 25320529 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Attiê R, Chinen LT, Yoshioka EM, Silva MC, de Lima VC Tags: World J Gastroenterol Source Type: research

C-reactive protein and fracture risk: European Prospective Investigation into Cancer Norfolk Study
Conclusion: A U-shaped association was observed between CRP and fracture risk. The increased risk of fracture observed at lower end of CRP compared to intermediate levels require further exploration, confirmation in other populations, and investigation into potential biological mechanisms.Highlights:
Source: Bone - July 17, 2013 Category: Orthopaedics Authors: Sara Ahmadi-Abhari, Robert N. Luben, Nicholas J. Wareham, Kay-Tee Khaw Tags: Original Articles Source Type: research

Chronic obstructive pulmonary disease.
Abstract The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD) in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes pr...
Source: The Indian Journal of Medical Research - February 1, 2013 Category: Biomedical Science Authors: Vijayan VK Tags: Indian J Med Res Source Type: research

Summary: International Kidney Cancer Symposium
Conclusions:  Ideal ischemia time is 20-25 minutes or less improves short and long term renal function.  >25 minutes carried 5 year risk of new onset stage 4 CKD No differences on GFR for cold vs. warm ischemia times Preoperative GFR and the percent of kidney preserved was a better predictor of post op GFR.  No ischemia preserves renal function better than warm. Longer cold ischemia times were equivalent to shorter warm ischemia times. Quality and quantity of the remaining kidney is associated with ultimate renal function. Robotics in RCC Surgery Gennady Bratslavsky, MD The...
Source: Kidney Cancer Association - December 15, 2011 Category: Urology & Nephrology Source Type: news

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