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Inflammation May Be the Culprit Behind Our Deadliest Diseases
In the early days of my medical residency, I met a man whom we’ll call Jason. He arrived to our emergency room on a holiday, nonchalant yet amiable, and complained of mild chest pain. Jason was tall and trim, with a strong South Boston accent and fingertips still faintly stained from his last home-improvement project. He was only 45 years old, but he looked much younger. He didn’t smoke, barely drank alcohol, and his cholesterol levels had always been normal. No one in his family had a history of heart disease. He asked us if we could work quickly—he wanted to be home for dinner with his daughters. [time-...
Source: TIME: Health - April 11, 2023 Category: Consumer Health News Authors: Shilpa Ravella Tags: Uncategorized freelance health Source Type: news

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Visceral Fat Triggers Heart Disease
I tell my patients to avoid drinking soda not just because they make you fat. Each sip of soda affects your health. Soda puts you at risk for health problems like metabolic syndrome. This is a collection of symptoms that can lead to diabetes, heart disease and other chronic diseases, like cancer. Soft drinks are the beverage of choice for millions of Americans. The latest research now reveals that sodas are a major cause of visceral fat — the deadliest kind of fat you can have, inflaming your tissues, rotting your blood vessels and upsetting your body chemistry. In a minute I’m going to tell you about a great healthy ...
Source: Al Sears, MD Natural Remedies - February 29, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Heart Health heart disease metabolic syndrome Visceral Fat Source Type: news

Catching Dick: Not Why We Care About Weight
Amy Schumer said in her humorous acceptance speech at the Glamour Women of the Year Awards: "I'm like 160 pounds right now, and I can catch a dick whenever I want, and that's the truth." The line, like many in her speech, is obviously very funny. But the humor is directed at a misperception that is not so funny. With our society's superficial focus on youth and appearance, we have emphasized all the wrong reasons for maintaining a healthy body weight, which has nothing to do with "catching dick." We are sold the idea that remaining slim is primarily important as a means of attracting the opposite sex, rather than as a pa...
Source: Science - The Huffington Post - June 4, 2015 Category: Science Source Type: news

Yes, It's Possible To Be Obese And Healthy (Sort Of)
Not every obese person is unhealthy. More than one-third of American adults with BMIs north of 30 also have a higher risk for developing conditions like type 2 diabetes, heart disease and stroke than the general population. But a small sliver of obese adults defy the odds, maintaining metabolic health despite the excess weight. Scientist don’t yet fully understand the biophysical mechanisms behind “fat but fit” or “healthy obese” -- and there’s even some disagreement about whether or not a healthy obese person can maintain their status over a lifetime. Two recent and unrelated analyses of metabolically healt...
Source: Science - The Huffington Post - January 8, 2015 Category: Science Source Type: news

No pain, no gain? Getting the most out of exercise
Staying in shape has all sorts of benefits, from maintaining heart health to warding off dementia and cancerInactivity – fuelled by cars and a sedentary work life – has been dubbed the biggest public health problem of the 21st century, a global pandemic with dramatic impact on peoples wellbeing. The latest reports suggest that around the world it was responsible for 5.3 million deaths in 2008 – around one in 10 – more deaths than smoking.Not only does exercise make you fitter, it can also ward off numerous and often unexpected diseases, from heart attacks, to diabetes, some forms of cancer and dementia. There are t...
Source: Guardian Unlimited Science - January 13, 2014 Category: Science Authors: Catherine de Lange Tags: Cycling Fitness Sport Running Transport Yoga Weightlifting Features UK news Life and style Cycle hire schemes The Observer Swimming Science Source Type: news