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Source: Frontiers in Neurology
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Total 2557 results found since Jan 2013.
Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study
This study aims to clarify the role of BoNT-A in the context of non-stroke spasticity (NSS). We enrolled 86 patients affected by multiple sclerosis, spinal cord injury, and traumatic brain injury with clinical indication to perform BoNT-A treatment. Subjects were evaluated before injection and after 1, 3, and 6 months. At every visit, spasticity severity using the modified Ashworth scale, pain using the numeric rating scale, QoL using the Euro Qol Group EQ-5D-5L, and the perceived treatment effect using the Global Assessment of Efficacy scale were recorded. In our population BoNT-A demonstrated to have a significant effect...
Source: Frontiers in Neurology - April 6, 2023 Category: Neurology Source Type: research
Validation of two automated ASPECTS software on non-contrast computed tomography scans of patients with acute ischemic stroke
ConclusionAutomated ASPECTS showed good reliability and 5 mm was the optimal slice thickness.
Source: Frontiers in Neurology - April 6, 2023 Category: Neurology Source Type: research
Investigation of shared genes and regulatory mechanisms associated with coronavirus disease 2019 and ischemic stroke
ConclusionThe four identified hub-shared genes may participate in crucial mechanisms underlying both COVID-19 and IS and may exhibit the potential to be biomarkers or therapeutic targets for the two diseases.
Source: Frontiers in Neurology - April 5, 2023 Category: Neurology Source Type: research
Comparative efficacy of gait training for balance outcomes in patients with stroke: A systematic review and network meta-analysis
ConclusionGait training is an effective treatment for improving stroke patients’ dynamic steady-state balance and balance test batteries. However, gait training had no significant effect on static steady-state balance and proactive balance. To achieve maximum efficacy, clinicians should consider this evidence when recommending rehabilitation training to stroke patients. Considering body-weight-supported treadmill is not common for chronic stroke patients in clinical practice, the treadmill is recommended for those who want to improve dynamic steady-state balance, and virtual reality gait training is recommended for those...
Source: Frontiers in Neurology - April 3, 2023 Category: Neurology Source Type: research
Global research trends on COVID-19 and stroke: A bibliometric analysis
ConclusionOur bibliometric analysis provides a comprehensive overview of the current state of research on COVID-19 and stroke and highlights key areas of focus in the field. Optimizing the treatment of COVID-19-infected stroke patients and elucidating the underlying pathogenic mechanisms of COVID-19 and stroke co-morbidity are key areas of future research that will be beneficial in improving the prognosis of stroke patients during the ongoing COVID-19 epidemic.
Source: Frontiers in Neurology - April 3, 2023 Category: Neurology Source Type: research
Associations between computed tomography markers of cerebral small vessel disease and hemorrhagic transformation after intravenous thrombolysis in acute ischemic stroke patients
ConclusionIn patients with acute ischemic stroke, severe leukoaraiosis, brain atrophy and total CSVD burden may be risk factors for HT after IVT. These findings may help improve efforts to mitigate or even prevent HT in vulnerable patients.
Source: Frontiers in Neurology - April 3, 2023 Category: Neurology Source Type: research
Silent infarction in sickle cell disease is associated with brain volume loss in excess of infarct volume
DiscussionWe demonstrate that anemia and decreased CaO2 are associated with reductions in GMV and WMV in SCD. Increased CBF and infarct burden were also associated with reduced volume in subcortical structures. Global WMV deficits associated with infarct burden far exceed infarct volume itself. Hemodynamic compensation via increased cerebral blood flow in SCD seems inadequate to prevent brain volume loss. Our work highlights that silent cerebral infarcts are just a portion of the brain injury that occurs in SCD; brain volume is another potential biomarker of brain injury in SCD.
Source: Frontiers in Neurology - March 31, 2023 Category: Neurology Source Type: research
Predictors of deep-vein thrombosis for acute stroke at admission to a rehabilitation unit: A retrospective study
ConclusionOlder age, lower BBS, and higher D-dimer levels at rehabilitation admission were independent risk factors for DVT. Therefore, ultrasonography should be performed for those patients with these three significant factors before implementing rehabilitation therapy.
Source: Frontiers in Neurology - March 31, 2023 Category: Neurology Source Type: research
Association between CORIN promoter methylation and stroke: Results from two independent samples of Chinese adults
ConclusionDNA methylation levels of the CORIN gene promoter were lower in stroke patients and predicted a higher risk of incident stroke in Chinese adults. The underlying causality warranted further investigation.
Source: Frontiers in Neurology - March 31, 2023 Category: Neurology Source Type: research
Aspiration thrombectomy of M2 middle cerebral artery occlusion to treat acute ischemic stroke: A core lab –adjudicated subset analysis from the COMPLETE registry and literature review
ConclusionFor appropriately selected patients, aspiration thrombectomy for acute ischemic stroke due to M2 MCA occlusion was safe and effective, with high rates of technical success and good functional outcome.
Source: Frontiers in Neurology - March 30, 2023 Category: Neurology Source Type: research
Stressed systems: Stroke unit bed occupancy and impact on reperfusion therapy in acute ischemic stroke
ConclusionAn increased bed occupancy level in the hour of the first hospital admission for stroke patients was strongly associated with decreased odds of receiving reperfusion therapy.
Source: Frontiers in Neurology - March 30, 2023 Category: Neurology Source Type: research
Women's reproductive traits and cerebral small-vessel disease: A two-sample Mendelian randomization study
ConclusionOur findings do not convincingly support a causal effect of women's reproductive factors on CSVD. Future studies are warranted to investigate specific estrogen-related physiological changes in women, which may inform current researchers on the causal mechanisms involved in cerebral small-vessel disease progression.
Source: Frontiers in Neurology - March 30, 2023 Category: Neurology Source Type: research
Impact of emergency department arrival time on door-to-needle time in patients with acute stroke
ConclusionFactors that contribute most to a delay in DTN time include arrival during the night shift, lack of a dedicated stroke team, longer time-to-CT read, and arrival as a walk-in. All of these are addressable factors from an operational standpoint and should be considered when performing quality improvement of hospital protocols.
Source: Frontiers in Neurology - March 30, 2023 Category: Neurology Source Type: research
Spatial CT perfusion data helpful in automatically locating vessel occlusions for acute ischemic stroke patients
ConclusionThe spatial layout of the hypoperfused region can help to automatically indicate the vessel occlusion location for acute ischemic stroke patients. However, variations in vessel architecture between patients seemed to limit the capacity of CTP data to distinguish between vessel occlusion locations more accurately.
Source: Frontiers in Neurology - March 29, 2023 Category: Neurology Source Type: research
The effect of intensive statin therapy in non-symptomatic intracranial arteries: The STAMINA-MRI sub-study
ConclusionIntensive statin therapy produced a favorable morphological change in cerebral arteries of not only the target arterial segment but also non-symptomatic arterial segments. The change in cerebral arterial luminal diameter was influenced by the baseline SBP and was dependent on the topographic distribution of the cerebral arteries.Clinical Trial Registration: ClinicalTrials.gov, identifier NCT02458755.
Source: Frontiers in Neurology - March 28, 2023 Category: Neurology Source Type: research
