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Vaccination: Ebola Vaccine

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Total 607 results found since Jan 2013.

One-step single-tube accelerated quantitative nucleoprotein gene-specific reverse transcription loop-mediated isothermal gene amplification (RT-LAMP) assay for rapid, real-time & amp; reliable clinical detection of Ebola virus
CONCLUSIONS: : Thus, due to easy operation without a requirement of sophisticated equipment and skilled personnel, the RT-LAMP assay reported here is a valuable tool as a point-of-care diagnosis for the rapid and real-time detection of Ebola virus in resource-limited healthcare settings of developing countries.PMID:35381703 | DOI:10.4103/ijmr.IJMR_864_19
Source: Indian J Med Res - April 6, 2022 Category: Research Authors: Jyoti S Kumar Paban Kumar Dash Ambuj Srivastava Shashi Sharma Kundan Tandel Manmohan Parida Source Type: research

Identification of novel Ebola virus inhibitors using biologically contained virus
In this study, we used biologically contained Ebola virus to screen over 4,200 small-molecule drugs and drug-like compounds provided by the Medicines for Malaria Venture (i.e., the Pandemic Response Box and the COVID Box) and the Centre for Drug Design and Discovery (CD3, KU Leuven, Belgium). In addition to confirming known Ebola virus inhibitors, illustrating the validity of our screening assays, we identified eight novel selective Ebola virus inhibitors. Although the inhibitory potential of these compounds remains to be validated in vivo, they represent interesting compounds for the study of potential interventions again...
Source: Antiviral Research - March 26, 2022 Category: Virology Authors: Bert Vanmechelen Joren Stroobants Winston Chiu Joost Schepers Arnaud Marchand Patrick Chaltin Kurt Vermeire Piet Maes Source Type: research

Viruses, Vol. 14, Pages 579: Therapeutic Strategies against Ebola Virus Infection
ung Lin Since the 2014–2016 epidemic, Ebola virus (EBOV) has spread to several countries and has become a major threat to global health. EBOV is a risk group 4 pathogen, which imposes significant obstacles for the development of countermeasures against the virus. Efforts have been made to develop anti-EBOV immunization and therapeutics, with three vaccines and two antibody-based therapeutics approved in recent years. Nonetheless, the high fatality of Ebola virus disease highlights the need to continuously develop antiviral strategies for the future management of EBOV outbreaks in conjunction with vaccinat...
Source: Viruses - March 11, 2022 Category: Virology Authors: Ching-Hsuan Liu Yee-Tung Hu Shu Hui Wong Liang-Tzung Lin Tags: Review Source Type: research

TWiV 871: If the ACE2 fits, ferret
TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists ASV Annual Meeting Registration (ASV) Microbiology & Immunology at LSU Health Is Omicron a new serotype? (Nat Rev Micr) Adaptation of SARS-CoV-2 to mink/ferret (Cell Rep) Letters read on T...
Source: This Week in Virology - MP3 Edition - February 27, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

The efficient development of a novel recombinant adenovirus zoster vaccine perfusion production process
This study demonstrates the perfusion process to be superior strategy for adenovirus-based vaccine production compared to the batch-mode strategy (1,467 IFU/cell). Furthermore, our PATFP system shows potential to be comparable to the XCell ATF® system, and it would become an alternative perfusion strategy for the vaccine production.PMID:35216843 | PMC:PMC8863426 | DOI:10.1016/j.vaccine.2022.02.024
Source: Vaccine - February 26, 2022 Category: Allergy & Immunology Authors: Jianqi Nie Yang Sun Kai Feng Lingling Huang Ye Li Zhonghu Bai Source Type: research