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Therapy: Corticosteroid Therapy
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Total 18794 results found since Jan 2013.
Adherence to 5-aminosalicylic acid maintenance treatment in young people with ulcerative colitis: a retrospective cohort study in primary care
CONCLUSION: The first year of starting long-term therapies in adolescents and young adults diagnosed with UC is a critical window for active follow-up of maintenance treatment, particularly in those aged 18-24 years and those living in deprived postcodes.PMID:37666511 | PMC:PMC10498382 | DOI:10.3399/BJGP.2023.0006
Source: The British Journal of General Practice - September 4, 2023 Category: Primary Care Authors: Nishani Jayasooriya Richard C Pollok Jonathan Blackwell Alex Bottle Irene Petersen Hanna Creese Sonia Saxena POP-IBD study group Source Type: research
Efficacy of combined strategies of physical activity, diet and sleep disorders as treatment in patients with chronic shoulder pain. A systematic review
The objective of this systematic review was to analyze the existing scientific evidence on the influence of dietary strategies, exercise, and sleep disorders on the symptomatology of patients with chronic shoulder pain, as well as to assess the methodological quality of the literature collected.Methods: The selection criteria were as follows: we included randomized controlled clinical trials written in English that investigated the effects of such interventions in patients with chronic shoulder pain and excluded studies where pre-operative rehabilitation or rehabilitation combined with corticosteroid injections was perform...
Source: Frontiers in Physiology - September 4, 2023 Category: Physiology Source Type: research
Acute liver failure following immune checkpoint inhibitors
We report the case of a 64-year-old man admitted to intensive care unit for liver failure secondary to immune-mediated hepatitis. This patient suffered from a progressing laryngeal squamous cell carcinoma. A treatment was started with immune checkpoint inhibitors combining anti PD-L1 plus novel anti-TIGIT or placebo (ATEZOLIZUMAB plus TIRAGOLUMAB or placebo), as part of a clinical trial. The patient then developed immune-mediated hepatitis, proven by liver biopsy. Despite 14 days of corticosteroids at 2 mg/kg the condition of the patient worsened, with the development of liver failure. The patient was admitted to intensive...
Source: Cell Research - September 3, 2023 Category: Cytology Authors: Thomas Renault Lucy Meunier Cl ément Monet Source Type: research
Clinical features and outcomes of children's interstitial lung disease accompanied with connective tissue disease: A prospective cohort study
CONCLUSIONS: Care providers should conduct an assessment for CTD in chILD as a longer interval between the diagnosis of chILD and the CTD is associated with increased mortality. Complications as ARDS predict poor outcome in CTD-chILD, while IVIG support combined with corticosteroids and immunosuppressants is a protective factor.PMID:37659436 | DOI:10.1016/j.rmed.2023.107402
Source: Respiratory Care - September 2, 2023 Category: Respiratory Medicine Authors: Gaoli Jiang Jingyi Xia Quanli Shen Weiming Chen Jianfeng Huang Libo Wang Li Sun Liling Qian Source Type: research
TWiV 1040: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the public health significance of finding autochthonous melioidosis cases in the continental United States, human neural larva migrans caused by Ophidascaris robertsi ascarid, Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics, excess all-cause mortality in China after ending the zero COVID policy, international pediatric COVID-19 severity over the course of the pandemic, differences in SARS-CoV-2 specific humoral and cellular immune responses after contralateral and ipsilateral COVID-19 vaccination, Pfizer and BioNTech ...
Source: This Week in Virology - MP3 Edition - September 2, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Non eosinophilic chronic stricturing esophagitis: lessons from thirty eight cases
CONCLUSION: The management of non-eosinophilic chronic stricturing esophagitis is challenging, because of a low contribution of esophageal biopsies and the refractory nature of the strictures. In our experience, a dermatological evaluation helped in 55% of cases to introduce a systemic treatment, leading to limit the use of endoscopic dilatation. Endoscopic follow-up is needed, considering the significant risk of esophageal squamous cell carcinoma.PMID:37657720 | DOI:10.1016/j.clinre.2023.102202
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Flavius-Stefan Marin Antoine Assaf Sarra Oumrani Vannina Seta Marianne Gaudric Fr édéric Beuvon Arthur Belle Romain Coriat Nicolas Dupin Stanislas Chaussade Maximilien Barret Source Type: research
A review: FDA-approved fluorine-containing small molecules from 2015 to 2022
Eur J Med Chem. 2023 Aug 24;260:115758. doi: 10.1016/j.ejmech.2023.115758. Online ahead of print.ABSTRACTFluorine-containing small molecules have occupied a special position in drug discovery research. The successful clinical use of fluorinated corticosteroids in the 1950s and fluoroquinolones in the 1980s led to an ever-increasing number of approved fluorinated compounds over the last 50 years. They have shown various biological properties such as antitumor, antimicrobial, and anti-inflammatory activities. Fluoro-pharmaceuticals have been considered a strong and practical tool in the rational drug design approach due to t...
Source: European Journal of Medicinal Chemistry - September 1, 2023 Category: Chemistry Authors: Negar Sheikhi Maryam Bahraminejad Mina Saeedi Seyedeh Sara Mirfazli Source Type: research
Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort
EClinicalMedicine. 2023 Jul 21;62:102107. doi: 10.1016/j.eclinm.2023.102107. eCollection 2023 Aug.ABSTRACTBACKGROUND: Lack of specific definitions of clinical characteristics, disease severity, and risk and preventive factors of post-COVID-19 syndrome (PCS) severely impacts research and discovery of new preventive and therapeutics drugs.METHODS: This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- and in-patients followed at 3-, 6-, and 12-month from diagnosis, with assessment of clinical and biochemical features, antibody (Ab) response, Variant o...
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Elisa Gentilotti Anna G órska Adriana Tami Roy Gusinow Massimo Mirandola Jes ús Rodríguez Baño Zaira R Palacios Baena Elisa Rossi Jan Hasenauer Iris Lopes-Rafegas Elda Righi Natascia Caroccia Salvatore Cataudella Zeno Pasquini Thomas Osmo Lidia Del Pi Source Type: research
Tofacitinib versus oral prednisolone for induction of remission in moderately active ulcerative colitis (ORCHID): A prospective, open-label, randomized, pilot study
CONCLUSION: In patients with moderately active ulcerative colitis, there was no difference in the efficacy and safety of tofacitinib and oral prednisolone for induction of remission at 8 weeks.PMID:37656880 | DOI:10.1093/ecco-jcc/jjad153
Source: Herpes - September 1, 2023 Category: Infectious Diseases Authors: Arshdeep Singh Vandana Midha Kirandeep Kaur Ramit Mahajan Dharmatma Singh Ramandeep Kaur Aditya Kohli Avantika Chawla Kriti Sood Namita Bansal Ajit Sood Source Type: research
