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Results of the European Society of Toxicologic Pathology Survey on the Use of Artificial Intelligence in Toxicologic Pathology
Toxicol Pathol. 2023 Jun;51(4):216-224. doi: 10.1177/01926233231182115.ABSTRACTThe European Society of Toxicologic Pathology (ESTP) initiated a survey through its Pathology 2.0 workstream in partnership with sister professional societies in Europe and North America to generate a snapshot of artificial intelligence (AI) usage in the field of toxicologic pathology. In addition to demographic information, some general questions explored AI relative to (1) the current status of adoption across organizations; (2) technical and methodological aspects; (3) perceived business value and finally; and (4) roadblocks and perspectives....
Source: Toxicologic Pathology - September 21, 2023 Category: Pathology Authors: Xavier Palazzi Erio Barale-Thomas Bhupinder Bawa Jonathan Carter Kyathanahalli Janardhan Heike Marxfeld Abraham Nyska Chandrassegar Saravanan Dirk Schaudien Vanessa L Schumacher Robert H Spaet Simone Tangermann Oliver C Turner Enrico Vezzali Source Type: research
Toxoplasma gondii induces pyroptosis in human placental trophoblast and amniotic cells by inducing ROS production and activation of cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 inflammasome
Toxoplasma gondii infection in pregnant women may cause fetal anomaly; however, the underlying mechanisms remain unclear. Here, we investigated whether T. gondii induces pyroptosis in human placental cells and the underlying mechanisms. Human placental trophoblast (BeWo and HTR-8/SVneo) and amniotic (WISH) cells were infected with T. gondii, and then ROS production, cathepsin B (CatB) release, inflammasome activation, and pyroptosis induction were evaluated. Moreover, the molecular mechanisms of these effects were investigated by treating the cells with ROS scavengers, a CatB inhibitor, or inflammasome-specific siRNA.
Source: American Journal of Pathology - September 21, 2023 Category: Pathology Authors: Juan-Hua Quan, Fei Fei Gao, Tian-Zhong Ma, Wei Ye, Xiang Gao, Ming-Zhu Deng, Lan-Lan Yin, In-Wook Choi, Jae-Min Yuk, Guang-Ho Cha, Young-Ha Lee, Jia-Qi Chu Tags: Regular Article Source Type: research
Gamna-Gandy body in a multinodular thyroid goiter
Ann Pathol. 2023 Sep 18:S0242-6498(23)00191-8. doi: 10.1016/j.annpat.2023.08.004. Online ahead of print.NO ABSTRACTPMID:37730460 | DOI:10.1016/j.annpat.2023.08.004
Source: Annales de Pathologie - September 20, 2023 Category: Pathology Authors: Morgane Dubois Aur élien Morini Source Type: research
Pathogenic Th17 cells in autoimmunity with regard to rheumatoid arthritis
Pathol Res Pract. 2023 Sep 15;250:154818. doi: 10.1016/j.prp.2023.154818. Online ahead of print.ABSTRACTTh17 cells contribute the pathobiology of autoimmune diseases, including rheumatoid arthritis (RA). However, it was shown that differentiated Th17 cells display a high degree of plasticity under the influence of inflammatory conditions. In some autoimmune diseases, the majority of Th17 cells, especially at sites of inflammation, have a phenotype that is intermediate between Th17 and Th1. These cells, which are described as Th17.1 or exTh17 cells, are hypothesized to be more pathogenic than classical Th17 cells. In this r...
Source: Pathology, Research and Practice - September 20, 2023 Category: Pathology Authors: Mehdi Toghi Sara Bitarafan Soudeh Ghafouri-Fard Source Type: research
MEK inhibition induces expression of differentiation marker Keratin 10 in human keratinocytes
Pathol Res Pract. 2023 Sep 2;250:154788. doi: 10.1016/j.prp.2023.154788. Online ahead of print.ABSTRACTBRAF mutant metastatic melanoma was regularly treated in the past with a BRAF inhibitor (BRAFi) alone or in combination with inhibitors of the mitogen-activated protein kinase kinase (MEKi), which is still a common treatment. This combination therapy strongly reduced the occurrence of keratoacanthomas and squamous cell carcinoma, which was frequently seen when BRAFi was used as monotherapy. Here we addressed the question whether MEK inhibition counteracts squamous cell carcinoma development in part by promoting keratinocy...
Source: Pathology, Research and Practice - September 20, 2023 Category: Pathology Authors: F Karras M Bonsack S Seifert L Friedrich M Kunz Source Type: research
Major Histocompatibility Class-I (MHC-I) downregulation in glioblastoma is a poor prognostic factor but not a predictive indicator for treatment failure
CONCLUSIONS: Glioblastoma with upregulated MHC-I showed a delayed tumor recurrence in comparison to those with downregulated MHC-I expression. However, downregulated MHC-I may not necessarily be an indicator of poor problems.PMID:37725880 | DOI:10.1016/j.prp.2023.154816
Source: Pathology, Research and Practice - September 19, 2023 Category: Pathology Authors: Nadeem S Butt Maher Kurdi Motaz M Fadul Sahar Hakamy Bassam M J Addas Eyad Faizo Shadi Alkhayyat Ahmed K Bamaga Taghreed Alsinani Yousef Katib Fahad Okel Yazid Maghrabi Abdulrahman J Sabbagh Rana Moshref Sultan Albalawi Alaa Alkhotani Fawaz Mohammed Nasse Source Type: research
Is the automated Elecsys tacrolimus assay on the Roche cobas e 602 analyzer an acceptable replacement for a liquid chromatography-tandem mass spectrometry-based assay?
CONCLUSIONS: The 2 major challenges for implementation of the tacrolimus ECLIA assay are the postextraction sample stability and the significant proportional bias observed compared with the LC-MS/MS reference method. The 30-minute window for analysis of extracted samples is a practical challenge to the routine workflow of the core laboratory. In addition, disagreement between the immunoassay and LC-MS/MS methods can lead to discordant clinical interpretations and ultimately affect patient care.PMID:37724434 | DOI:10.1093/ajcp/aqad114
Source: American Journal of Clinical Pathology - September 19, 2023 Category: Pathology Authors: Anastasia Gant Kanegusuku Kiang-Teck J Yeo Source Type: research
Major Histocompatibility Class-I (MHC-I) downregulation in glioblastoma is a poor prognostic factor but not a predictive indicator for treatment failure
CONCLUSIONS: Glioblastoma with upregulated MHC-I showed a delayed tumor recurrence in comparison to those with downregulated MHC-I expression. However, downregulated MHC-I may not necessarily be an indicator of poor problems.PMID:37725880 | DOI:10.1016/j.prp.2023.154816
Source: Pathology, Research and Practice - September 19, 2023 Category: Pathology Authors: Nadeem S Butt Maher Kurdi Motaz M Fadul Sahar Hakamy Bassam M J Addas Eyad Faizo Shadi Alkhayyat Ahmed K Bamaga Taghreed Alsinani Yousef Katib Fahad Okel Yazid Maghrabi Abdulrahman J Sabbagh Rana Moshref Sultan Albalawi Alaa Alkhotani Fawaz Mohammed Nasse Source Type: research
Is the automated Elecsys tacrolimus assay on the Roche cobas e 602 analyzer an acceptable replacement for a liquid chromatography-tandem mass spectrometry-based assay?
CONCLUSIONS: The 2 major challenges for implementation of the tacrolimus ECLIA assay are the postextraction sample stability and the significant proportional bias observed compared with the LC-MS/MS reference method. The 30-minute window for analysis of extracted samples is a practical challenge to the routine workflow of the core laboratory. In addition, disagreement between the immunoassay and LC-MS/MS methods can lead to discordant clinical interpretations and ultimately affect patient care.PMID:37724434 | DOI:10.1093/ajcp/aqad114
Source: American Journal of Clinical Pathology - September 19, 2023 Category: Pathology Authors: Anastasia Gant Kanegusuku Kiang-Teck J Yeo Source Type: research
The characterization and correlation between the phenotypic and genotypic resistance of < em > Campylobacter < /em > spp < em > . < /em > isolates from commercial broilers and native chickens in the south of Thailand
Avian Pathol. 2023 Sep 18:1-49. doi: 10.1080/03079457.2023.2260322. Online ahead of print.ABSTRACTAbstractChicken is a major reservoir and source of human infections from zoonotic Campylobacter. In southern Thailand, chicken is the most popular meat consumed; however, little is known about the antimicrobial resistance (AMR) of Campylobacter spp. in chicken production systems. We aimed to investigate the prevalence and characteristics of AMR in Campylobacter isolates from commercial broiler and native chicken farms in southern Thailand. A total of 286 Campylobacter isolates (adjusted prevalence: 60.3%, SE ±0.01) were recov...
Source: Avian Pathology - September 18, 2023 Category: Pathology Authors: Doan Hoang Phu Ruethai Narinthorn Nguyen Thi Nhung Niwat Chansiripornchai Patrick J Blackall Conny Turni Juan Carrique-Mas Thotsapol Thomrongsuwannakij Source Type: research
Corrigendum to: "Dihydroartemisinin inhibits the growth and invasion of gastric cancer cells by regulating cyclin D1-CDK4-Rb signaling" Pathol. Res. Pract. 216 (2020) 152795
Pathol Res Pract. 2023 Sep 16:154824. doi: 10.1016/j.prp.2023.154824. Online ahead of print.NO ABSTRACTPMID:37722992 | DOI:10.1016/j.prp.2023.154824
Source: Pathology, Research and Practice - September 18, 2023 Category: Pathology Authors: Hui-Ning Fan Mei-Ying Zhu Shi-Qiao Peng Jin-Shui Zhu Jing Zhang Guo-Qiang Qu Source Type: research
Dynamic Multiplex Tissue Imaging in Inflammation Research
Annu Rev Pathol. 2023 Sep 18. doi: 10.1146/annurev-pathmechdis-070323-124158. Online ahead of print.ABSTRACTInflammation is a highly dynamic process with immune cells that continuously interact with each other and parenchymal components as they migrate through tissue. The dynamic cellular responses and interaction patterns are a function of the complex tissue environment that cannot be fully reconstructed ex vivo, making it necessary to assess cell dynamics and changing spatial patterning in vivo. These dynamics often play out deep within tissues, requiring the optical focus to be placed far below the surface of an opaque ...
Source: Annual Review of Pathology - September 18, 2023 Category: Pathology Authors: Stefan Uderhardt Georgiana Neag Ronald N Germain Source Type: research
Diffuse Pleural Mesothelioma: Advances in Molecular Pathogenesis, Diagnosis and Treatment
Annu Rev Pathol. 2023 Sep 18. doi: 10.1146/annurev-pathol-042420-092719. Online ahead of print.ABSTRACTDiffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidiscip...
Source: Annual Review of Pathology - September 18, 2023 Category: Pathology Authors: Christopher A Febres-Aldana Rachel Fanaroff Michael Offin Marjorie G Zauderer Jennifer L Sauter Soo-Ryum Yang Marc Ladanyi Source Type: research
Corrigendum to: "Dihydroartemisinin inhibits the growth and invasion of gastric cancer cells by regulating cyclin D1-CDK4-Rb signaling" Pathol. Res. Pract. 216 (2020) 152795
Pathol Res Pract. 2023 Sep 16:154824. doi: 10.1016/j.prp.2023.154824. Online ahead of print.NO ABSTRACTPMID:37722992 | DOI:10.1016/j.prp.2023.154824
Source: Pathology, Research and Practice - September 18, 2023 Category: Pathology Authors: Hui-Ning Fan Mei-Ying Zhu Shi-Qiao Peng Jin-Shui Zhu Jing Zhang Guo-Qiang Qu Source Type: research
