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Total 61866 results found since Jan 2013.
Depletion of Bone Marrow Hematopoietic Cells in Ebola Virus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebola Virus Disease
Am J Pathol. 2023 Sep 7:S0002-9440(23)00316-4. doi: 10.1016/j.ajpath.2023.08.010. Online ahead of print.ABSTRACTThe pathophysiology of long-recognized hematological abnormalities in Ebola virus disease (EVD) is unknown. From limited human sampling (of peripheral blood), it has been postulated that emergency hematopoiesis plays a role in severe EVD, but the systematic characterization of the bone marrow (BM) has not occurred in human disease or in nonhuman primate models. In a lethal rhesus macaque (RhM) model of EVD, sternal BMs from eighteen RhMs were characterized after intramuscular exposure to Ebola virus (EBOV) Kikwit...
Source: Am J Pathol - September 9, 2023 Category: Pathology Authors: David X Liu Bapi Pahar Donna L Perry Huanbin Xu Timothy K Cooper Louis M Huzella Randy J Hart Amanda M W Hischak John Bernbaum Marisa St Claire Russell Byrum Richard S Bennett Travis Warren Michael R Holbrook Lisa E Hensley Ian Crozier Connie S Schmaljohn Source Type: research
The Role of Endoplasmic Reticulum in Lipotoxicity during MASLD Pathogenesis
Am J Pathol. 2023 Sep 7:S0002-9440(23)00314-0. doi: 10.1016/j.ajpath.2023.08.007. Online ahead of print.ABSTRACTPerturbations in lipid and protein homeostasis induce endoplasmic reticulum (ER) stress in metabolic-dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD). Lipotoxic and proteotoxic stress can activate the unfolded protein response (UPR) transducers: Inositol Requiring Enzyme1α, PKR-like ER Kinase and Activating Transcription Factor 6α. Collectively, these pathways induce expression of genes that encode functions to resolve the protein folding defect ...
Source: Am J Pathol - September 9, 2023 Category: Pathology Authors: Nanditha Venkatesan Luke C Doskey Harmeet Malhi Source Type: research
Elucidating the morphogenic and signaling roles of defined growth factors controlling human endothelial cell lumen formation versus sprouting behavior
Am J Pathol. 2023 Sep 7:S0002-9440(23)00317-6. doi: 10.1016/j.ajpath.2023.08.009. Online ahead of print.ABSTRACTWe have previously shown that five growth factors (Factors) [i.e. insulin, fibroblast growth factor-2 (FGF-2), stem cell factor (SCF), interleukin-3 (IL-3), and stromal-derived factor-1 alpha (SDF-1α)] in combination are necessary for human ECs to undergo tube morphogenesis, a process requiring both lumen formation and sprouting behavior. Here, we investigate why they are required by subdividing the Factors into 4 separate groups: Insulin only, Insulin + FGF-2, no FGF-2 (all Factors but without FGF-2), and all F...
Source: Am J Pathol - September 9, 2023 Category: Pathology Authors: Prisca K Lin Gretchen M Koller George E Davis Source Type: research
Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
This study verified previous work in which exposure to 5-dihydrotestosterone (DHT) and insulin (INS) in rats during pregnancy resulted in hyperandrogenism, insulin intolerance, and higher foetal mortality. It also found that exposure to DHT and INS dysregulated the expression of angiogenesis-related genes in the uterus and placenta. It also decreased expression of endothelial nitric oxide synthase and matrix metallopeptidases 2 and 9, increased fibrotic collagen deposits in the uterus, and reduced expression of marker genes for SpA-associated trophoblast giant cells. These changes were related to a greater proportion of un...
Source: Am J Pathol - September 9, 2023 Category: Pathology Authors: Min Hu Yuehui Zhang Xu Zhang XiuYing Zhang Xinyue Huang Yaxing Lu Yijia Li Mats Br ännström Amanda Nancy Sferruzzi-Perri Linus R Shao H åkan Billig Source Type: research
Unrevealing the vital role of ncRNAs in Gastric Cancer chemoresistance
Pathol Res Pract. 2023 Aug 10;250:154761. doi: 10.1016/j.prp.2023.154761. Online ahead of print.ABSTRACTThe high incidence of gastric cancer in many nations and poor overall survival rates has remained a serious global health concern. Chemoresistance in gastric cancer is a significant issue that hinders the efficacy of available treatment options. In gastric cancer, non-coding RNAs like microRNAs, long non-coding RNAs, and circular RNAs have become effective regulators of chemoresistance. These non-coding RNAs can influence several mechanisms, including drug efflux transporters, drug metabolism, and detoxification, cancer ...
Source: Pathology, Research and Practice - September 9, 2023 Category: Pathology Authors: Aida Kazemi Masomeh Goodarzi Kosar Daneshipour Hoda Sarabadani Zahra Shahpar Bahareh Salmanian Hajiagha Hadis Kheradjoo Saman Mohammadzadehsaliani Source Type: research
Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
This study verified previous work in which exposure to 5-dihydrotestosterone (DHT) and insulin (INS) in rats during pregnancy resulted in hyperandrogenism, insulin intolerance, and higher foetal mortality. It also found that exposure to DHT and INS dysregulated the expression of angiogenesis-related genes in the uterus and placenta. It also decreased expression of endothelial nitric oxide synthase and matrix metallopeptidases 2 and 9, increased fibrotic collagen deposits in the uterus, and reduced expression of marker genes for SpA-associated trophoblast giant cells. These changes were related to a greater proportion of un...
Source: The American Journal of Pathology - September 9, 2023 Category: Pathology Authors: Min Hu Yuehui Zhang Xu Zhang XiuYing Zhang Xinyue Huang Yaxing Lu Yijia Li Mats Br ännström Amanda Nancy Sferruzzi-Perri Linus R Shao H åkan Billig Source Type: research
Unrevealing the vital role of ncRNAs in Gastric Cancer chemoresistance
Pathol Res Pract. 2023 Aug 10;250:154761. doi: 10.1016/j.prp.2023.154761. Online ahead of print.ABSTRACTThe high incidence of gastric cancer in many nations and poor overall survival rates has remained a serious global health concern. Chemoresistance in gastric cancer is a significant issue that hinders the efficacy of available treatment options. In gastric cancer, non-coding RNAs like microRNAs, long non-coding RNAs, and circular RNAs have become effective regulators of chemoresistance. These non-coding RNAs can influence several mechanisms, including drug efflux transporters, drug metabolism, and detoxification, cancer ...
Source: Pathology, Research and Practice - September 9, 2023 Category: Pathology Authors: Aida Kazemi Masomeh Goodarzi Kosar Daneshipour Hoda Sarabadani Zahra Shahpar Bahareh Salmanian Hajiagha Hadis Kheradjoo Saman Mohammadzadehsaliani Source Type: research
MicroRNA-143 as a potential tumor suppressor in cancer: An insight into molecular targets and signaling pathways
Pathol Res Pract. 2023 Sep 6;250:154792. doi: 10.1016/j.prp.2023.154792. Online ahead of print.ABSTRACTMicroRNAs (MiRNAs), which are highly conserved and small noncoding RNAs, negatively regulate gene expression and influence signaling pathways involved in essential biological activities, including cell proliferation, differentiation, apoptosis, and cell invasion. MiRNAs have received much attention in the past decade due to their significant roles in cancer development. In particular, microRNA-143 (miR-143) is recognized as a tumor suppressor and is downregulated in most cancers. However, it seems that miR-143 is upregula...
Source: Pathology, Research and Practice - September 9, 2023 Category: Pathology Authors: Vahid Asghariazar Mahtab Kadkhodayi Mehdi Sarailoo Amir Ghaffari Jolfayi Behzad Baradaran Source Type: research
Depletion of Bone Marrow Hematopoietic Cells in Ebola Virus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebola Virus Disease
Am J Pathol. 2023 Sep 7:S0002-9440(23)00316-4. doi: 10.1016/j.ajpath.2023.08.010. Online ahead of print.ABSTRACTThe pathophysiology of long-recognized hematological abnormalities in Ebola virus disease (EVD) is unknown. From limited human sampling (of peripheral blood), it has been postulated that emergency hematopoiesis plays a role in severe EVD, but the systematic characterization of the bone marrow (BM) has not occurred in human disease or in nonhuman primate models. In a lethal rhesus macaque (RhM) model of EVD, sternal BMs from eighteen RhMs were characterized after intramuscular exposure to Ebola virus (EBOV) Kikwit...
Source: The American Journal of Pathology - September 9, 2023 Category: Pathology Authors: David X Liu Bapi Pahar Donna L Perry Huanbin Xu Timothy K Cooper Louis M Huzella Randy J Hart Amanda M W Hischak John Bernbaum Marisa St Claire Russell Byrum Richard S Bennett Travis Warren Michael R Holbrook Lisa E Hensley Ian Crozier Connie S Schmaljohn Source Type: research
The Role of Endoplasmic Reticulum in Lipotoxicity during MASLD Pathogenesis
Am J Pathol. 2023 Sep 7:S0002-9440(23)00314-0. doi: 10.1016/j.ajpath.2023.08.007. Online ahead of print.ABSTRACTPerturbations in lipid and protein homeostasis induce endoplasmic reticulum (ER) stress in metabolic-dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD). Lipotoxic and proteotoxic stress can activate the unfolded protein response (UPR) transducers: Inositol Requiring Enzyme1α, PKR-like ER Kinase and Activating Transcription Factor 6α. Collectively, these pathways induce expression of genes that encode functions to resolve the protein folding defect ...
Source: The American Journal of Pathology - September 9, 2023 Category: Pathology Authors: Nanditha Venkatesan Luke C Doskey Harmeet Malhi Source Type: research
Elucidating the morphogenic and signaling roles of defined growth factors controlling human endothelial cell lumen formation versus sprouting behavior
Am J Pathol. 2023 Sep 7:S0002-9440(23)00317-6. doi: 10.1016/j.ajpath.2023.08.009. Online ahead of print.ABSTRACTWe have previously shown that five growth factors (Factors) [i.e. insulin, fibroblast growth factor-2 (FGF-2), stem cell factor (SCF), interleukin-3 (IL-3), and stromal-derived factor-1 alpha (SDF-1α)] in combination are necessary for human ECs to undergo tube morphogenesis, a process requiring both lumen formation and sprouting behavior. Here, we investigate why they are required by subdividing the Factors into 4 separate groups: Insulin only, Insulin + FGF-2, no FGF-2 (all Factors but without FGF-2), and all F...
Source: The American Journal of Pathology - September 9, 2023 Category: Pathology Authors: Prisca K Lin Gretchen M Koller George E Davis Source Type: research
Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
This study verified previous work in which exposure to 5-dihydrotestosterone (DHT) and insulin (INS) in rats during pregnancy resulted in hyperandrogenism, insulin intolerance, and higher foetal mortality. It also found that exposure to DHT and INS dysregulated the expression of angiogenesis-related genes in the uterus and placenta. It also decreased expression of endothelial nitric oxide synthase and matrix metallopeptidases 2 and 9, increased fibrotic collagen deposits in the uterus, and reduced expression of marker genes for SpA-associated trophoblast giant cells. These changes were related to a greater proportion of un...
Source: The American Journal of Pathology - September 9, 2023 Category: Pathology Authors: Min Hu Yuehui Zhang Xu Zhang XiuYing Zhang Xinyue Huang Yaxing Lu Yijia Li Mats Br ännström Amanda Nancy Sferruzzi-Perri Linus R Shao H åkan Billig Source Type: research
Roots remain
Exp Mol Pathol. 2023 Sep 7:104868. doi: 10.1016/j.yexmp.2023.104868. Online ahead of print.NO ABSTRACTPMID:37689097 | DOI:10.1016/j.yexmp.2023.104868
Source: Experimental and Molecular Pathology - September 9, 2023 Category: Pathology Authors: Marco Giudici Source Type: research
L ’essentiel sur la biopsie gastrique tumorale. Cas anatomocliniques n < sup > o < /sup > 3
Ann Pathol. 2023 Sep 7:S0242-6498(23)00163-3. doi: 10.1016/j.annpat.2023.07.005. Online ahead of print.NO ABSTRACTPMID:37689577 | DOI:10.1016/j.annpat.2023.07.005
Source: Annales de Pathologie - September 9, 2023 Category: Pathology Authors: Beno ît Terris Source Type: research
Case no. 2
Ann Pathol. 2023 Sep 7:S0242-6498(23)00165-7. doi: 10.1016/j.annpat.2023.07.007. Online ahead of print.NO ABSTRACTPMID:37689576 | DOI:10.1016/j.annpat.2023.07.007
Source: Annales de Pathologie - September 9, 2023 Category: Pathology Authors: Florence Renaud Source Type: research
