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Tenascins and osteopontin in biological response in cornea
Ocul Surf. 2023 May 18;29:131-149. doi: 10.1016/j.jtos.2023.05.005. Online ahead of print.ABSTRACTThe structural composition, integrity and regular curvature of the cornea contribute to the maintenance of its transparency and vision. Disruption of its integrity caused by injury results in scarring, inflammation and neovascularization followed by losses in transparency. These sight compromising effects is caused by dysfunctional corneal resident cell responses induced by the wound healing process. Upregulation of growth factors/cytokines and neuropeptides affect development of aberrant behavior. These factors trigger kerato...
Source: The Ocular Surface - May 20, 2023 Category: Opthalmology Authors: Takayoshi Sumioka Ken-Ichi Matsumoto Peter Sol Reinach Shizuya Saika Source Type: research
Featured Health IT Job: Procurement Coordinator
We like to regularly feature a healthcare IT job that might be of interest to readers. Today, we’re featuring the Procurement Coordinator position that was recently posted on Healthcare IT Central. This position was posted by New York eHealth Collaborative and is in New York.
Here’s a description of the position:
New York eHealth Collaborative (NYeC) is a not-for-profit organization working in partnership with the New York State Department of Health to improve healthcare by collaboratively leading, connecting, and integrating health information exchange across the State.
Founded in 2006 by healthcare leaders,...
Source: EMR and HIPAA - May 17, 2023 Category: Information Technology Authors: Health IT Jobs Tags: Career and Jobs Healthcare IT Health IT Jobs Health IT Procurement Healthcare IT Jobs Job Seekers New York eHealth Collaborative New York Health IT Jobs NYeC Procurement Coordinator Source Type: blogs
Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database
EClinicalMedicine. 2023 Mar 20;58:101909. doi: 10.1016/j.eclinm.2023.101909. eCollection 2023 Apr.ABSTRACTBACKGROUND: The Prospective Lynch Syndrome Database (PLSD) collates information on carriers of pathogenic or likely pathogenic MMR variants (path_MMR) who are receiving medical follow-up, including colonoscopy surveillance, which aims to the achieve early diagnosis and treatment of cancers. Here we use the most recent PLSD cohort that is larger and has wider geographical representation than previous versions, allowing us to present mortality as an outcome, and median ages at cancer diagnoses for the first time.METHODS:...
Source: Cancer Control - May 14, 2023 Category: Cancer & Oncology Authors: Mev Dominguez-Valentin Saskia Haupt Toni T Sepp älä Julian R Sampson Lone Sunde Inge Bernstein Mark A Jenkins Christoph Engel Stefan Aretz Maartje Nielsen Gabriel Capella Francesc Balaguer Dafydd Gareth Evans John Burn Elke Holinski-Feder Lucio Bertario Source Type: research
P19-derived neuronal cells express H < sub > 1 < /sub > , H < sub > 2 < /sub > , and H < sub > 3 < /sub > histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents
This report aimed to characterize the response of neurons differentiated from mouse P19 embryonal carcinoma cells to histamine treatment, and to investigate the modulation of this response by antihistamine drugs, vegetal diamine oxidase, and catalase. The exposure of P19 neurons to histamine reduced cell viability to 65% maximally. This effect involves specific histamine receptors, since it was prevented by treatment with desloratadine and cimetidine, respectively, H1 and H2 antagonists, but not by the H3 antagonist ciproxifan. RT-PCR analysis showed that P19 neurons express H1 and H2 receptors, and the H3 receptor, althou...
Source: Amino Acids - May 12, 2023 Category: Biochemistry Authors: Mariela Gomez Perez Georgiana Tanasie Armelle Tchoumi Neree Narjara Gonzalez Suarez Clara Lafortune Joanne Paquin Lucia Marcocci Paola Pietrangeli Borhane Annabi Mircea Alexandru Mateescu Source Type: research
Check Out These Public Federal Funding Databases to Learn More About Funding at NIH and Other Federal Agencies
We often recommend NIH RePORT (Research Portfolio Online Reporting Tools) site to applicants & awardees because it publicly provides reports, data, and analyses of NIH research activities, including information on NIH expenditures and the results of NIH-supported research. The RePORT suite includes:
NIH RePORTER (RePORT Expenditures and Results) allows users to search for funded projects, investigators, publications, and patents (see this NIH Open Mike blog for more). REPORTER also includes information on research projects funded by the Centers for Disease Control and Prevention, Food and Drug Administration, Agenc...
Source: NIH Extramural Nexus - May 9, 2023 Category: Research Authors: NIH Staff Tags: Tips Before You Submit Funding data Source Type: funding
Contractile and expansive actin networks in Drosophila: Developmental cell biology controlled by network polarization and higher-order interactions
Curr Top Dev Biol. 2023;154:99-129. doi: 10.1016/bs.ctdb.2023.02.005. Epub 2023 Mar 14.ABSTRACTActin networks are central to shaping and moving cells during animal development. Various spatial cues activate conserved signal transduction pathways to polarize actin network assembly at sub-cellular locations and to elicit specific physical changes. Actomyosin networks contract and Arp2/3 networks expand, and to affect whole cells and tissues they do so within higher-order systems. At the scale of tissues, actomyosin networks of epithelial cells can be coupled via adherens junctions to form supracellular networks. Arp2/3 netwo...
Source: Current Topics in Developmental Biology - April 26, 2023 Category: Biology Authors: Rodrigo Fernandez-Gonzalez Tony J C Harris Source Type: research
