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Source: GEO: Gene Expression Omnibus
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Total 1028 results found since Jan 2013.
GSE176315 A genetics screen uncovers the role of RNA-binding protein RBP45D in flowering time under heat and DCL3-independent RNA-directed DNA methylation
Contributor : Tatjana KleineSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaIn the canonical RdDM, small interfering RNAs (siRNAs) are produced through the slicer activity of DICER-LIKE 3 (DCL3). Here, we describe the Arabidopsis thaliana prors1 (LUC) transgenic system in which transcriptional gene silencing (TGS) through RdDM is independent of DLC3. To identify players in the DCL3-independent pathway, a forward genetics screen was performed with the prors1 (LUC) system to identify suppressor mutants in which TGS is released. Among already known components of RdDM, we identifi...
Source: GEO: Gene Expression Omnibus - May 13, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE196499 Gene expression (GeneChip) data from scramble- and CRMP2A siRNA-treated A549 cells.
Contributors : Aristeidis E Boukouris ; Evangelos D MichelakisSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe sought to assess how temporary loss of the microtubule-associated protein CRMP2A could affect global gene expression in the A549 lung cancer cells.We used microarrays to identify differentially regulated genes when CRMP2A is temporarily removed from A549 cells using siRNA.
Source: GEO: Gene Expression Omnibus - May 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE201693 The Role of Quiescent Cells in the Maintenance of the Thyroid Gland
Contributor : Rob P CoppesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe regenerative capacities of an organ rely on the presence of (adult) tissue-specific stem cells. With regards to the thyroid gland, the existence of adult stem cells remains a topic of controversy. Previously, evidence has already suggested the presence of a population of thyroid cells with self-renewal capacity, capable of long-term culturing in vitro. However, the mechanisms that govern these proliferative abilities remain poorly understood. In addition, the slow turnover rate of the tissue-specific cells c...
Source: GEO: Gene Expression Omnibus - April 29, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE179843 Mammalian UPF3A and UPF3B activate NMD independently of their EJC binding
Contributors : Zhongxia Yi ; Rene M Arvola ; Sean Myers ; Corinne N Dilsavor ; Rabab Abu Alhasan ; Bayley N Carter ; Robert D Patton ; Ralf Bundschuh ; Guramrit SinghSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensNonsense-mediated mRNA decay (NMD) can occur independently of some NMD factors such as UPF3B. We have performed total RNA-Seq in HCT116 cells under NMD factor knockout (with CRISPR-Cas9) and/or knockdown (with siRNA transfection) conditions to identify mRNA substrates regulated by different NMD factors. We have also performed RIPiT-Seq to identify the footprints of t...
Source: GEO: Gene Expression Omnibus - April 23, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE200983 Effect of O-GlcNAc Transferase (OGT) siRNA in trophoblastic BeWo cells
Contributors : Stephanie Olivier-Van Stichelen ; Yiwen CuiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEvery year, about 18 million babies are born from mothers with gestational diabetes mellitus (GDM). While diabetic symptoms usually resolve after delivery, lasting complications can occur for both mother and child, including fetal overgrowth, type 2 diabetes (T2D), cardiovascular diseases, and obesity. The rapid progression of GDM is unique to pregnancies, and likely arises from placental dysfunction. Indeed, stress, nutrition and fetal gender are thought to trigger changes in pla...
Source: GEO: Gene Expression Omnibus - April 21, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE197389 RANKL regulates testicular cancer growth and Denosumab has tumor suppressive effects in GCNIS and advanced seminoma
In conclusion, this study shows that the RANKL signaling system is expressed in GCNIS and seminoma where RANKL inhibition suppress tumor growth in vitro and in vivo. Future studies are needed to determine whether RANKL is important for the malignant transformation and the transition from GCNIS to invasive tumors.
Source: GEO: Gene Expression Omnibus - April 19, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE149022 Next generation sequencing quantitatively analyzes transcriptomes of primary CLL cells tranfected with non-specific control (NSC) or ZAP-70 siRNA
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - April 19, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE149021 Next generation sequencing quantitatively analyzes transcriptomes of primary CLL cells tranfected with non-specific control (NSC) or ZAP-70 siRNA (+anti-IgM dataset)
Contributors : Jingyu Chen ; Vijitha Sathiaseelan ; Arash Shahsavari ; Irina Mohorianu ; Ingo RingshausenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA seq profiles of primary CLL cells transfected with non-specific control (NSC) or ZAP-70 siRNA ± anti-IgM. This submission is +anti-IgM.
Source: GEO: Gene Expression Omnibus - April 19, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE149020 Next generation sequencing quantitatively analyzes transcriptomes of primary CLL cells tranfected with non-specific control (NSC) or ZAP-70 siRNA (-anti-IgM dataset)
Contributors : Jingyu Chen ; Vijitha Sathiaseelan ; Arash Shahsavari ; Irina Mohorianu ; Ingo RingshausenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA seq profiles of primary CLL cells transfected with non-specific control (NSC) or ZAP-70 siRNA ± anti-IgM. This submission is -anti-IgM.
Source: GEO: Gene Expression Omnibus - April 19, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE200861 Tumor promoting effect of long non-coding RNA RP11-556E13.1 and its clinical significance as a prognostic factor in hepatocellular carcinoma.
Contributors : Jie Li ; Zhikun Liu ; Jianguo Wang ; Xuyong Wei ; Qiang Wei ; Shusen Zheng ; Xiao XuSeries Type : Expression profiling by arrayOrganism : Homo sapiensObjective: The aim of this study was to reveal the function of the long non-coding RNA (lncRNA) RP11-556E13.1 (RP11) and its clinical significance in hepatocellular carcinoma.Methods: LncRNA and mRNA expression profiling was performed using lncRNA and mRNA microarrays in 5 pairs of HCC and adjacent tissues. 112 paired HCC and adjacent tissue samples were analyzed by semiquantitative real-time polymerase chain reaction (sqRT-PCR) to evaluate the expression of RP...
Source: GEO: Gene Expression Omnibus - April 18, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE200312 Glucocorticoid recptor knockdown in primary amnion epithelial cells treated with MPA and TNFa
Contributors : Sarah J Cunningham ; Terrence K Allen ; Tim E Reddy ; Alejandro BarreraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo analyze the effect of glucocorticoids on primary amnion epthelial cells, we harvested tissue samples from 10 healthy ceseaean section patients. We knocked down the glucocorticoid receptor with an siRNA or used a control siRNA. We treated samples with medroxyprogesterone acetate. Half the cells we subjected to a TNFa challenge
Source: GEO: Gene Expression Omnibus - April 9, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE199944 Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration
In this study, we investigated the functional role of high-mobility group box 2 (HMGB2), a chromatin protein in liver regeneration using wild-type and HMGB2-knockout (KO) mice. Liver tissues were sampled after 70% partial hepatectomy (PHx), and analyzed by immunohistochemistry using various markers of cell proliferation, including Ki-67, PCNA, cyclin D1, cyclin B1, EdU and pH3S10. In WT mice, hepatocyte proliferation was strongly correlated with the spatiotemporal expression of HMGB2; however, cell proliferation was significantly delayed in hepatocytes of HMGB2-KO mice. Quantitative PCR demonstrated that cyclin D1 and cyc...
Source: GEO: Gene Expression Omnibus - April 3, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
GSE194248 Human prostate cancer cells (VCaP and AIVCaP): siAR alone (single siRNA) vs. siAR plus OPRK1 (combo-siRNA)
Contributors : Yuki Makino ; Takashi KobayashiSeries Type : Expression profiling by arrayOrganism : Homo sapiensThrough comparative genomics using PDX models of androgen-dependent (AD) and castration-resistant (CR) tumors, we identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistance. Loss of OPRK1 function delays castration-resistance and inhibits castration-resistant growth of prostate cancer cells in culture and in vivo, suggesting OPRK1 as a therapeutic target.To gain insight with regard to biological function of OPRK1 under androgen-depleted condition, we set up two distinct comparisons us...
Source: GEO: Gene Expression Omnibus - April 3, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE199026 ATF6 is required for the survival of castration-resistant prostate cancer cells
Contributors : Tingting Zhang ; Faming Zhao ; Xia ShengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo gain insight into the global ATF6 target gene profile in prostate cancer cells, we performed RNA-seq analysis in DU145 cells upon either ATF6 siRNA-mediated knockdown (siATF6) or Ceapin-A7-mediated ATF6 α inhibition.
Source: GEO: Gene Expression Omnibus - March 23, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE171974 JMJD6 is a possible epigenetic regulator of PD-L1 expression and an independent favorable prognostic factor of intrahepatic cholangiocarcinoma
Contributors : Yukiko Kosai-Fujimoto ; Daisuke Okuzaki ; Takasuke FukuharaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAssociation of Jumonji domain-containing 6 (JMJD6) with outcomes of various cancers has been shown, however the impact on intrahepatic cholangiocarcinoma (ICC) has never been reported yet. The aim of this study is to clarify the role of JMJD6 in the clinical settings and the impact on the outcomes of ICC. The resected liver specimens of 53 patients who underwent surgery for ICC were analyzed for JMJD6 expression by immunohistochemistry staining. The relationship be...
Source: GEO: Gene Expression Omnibus - March 23, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
