Filtered By:
Source: GEO: Gene Expression Omnibus

This page shows you your search results in order of date. This is page number 5.

Order by Relevance | Date

Total 1028 results found since Jan 2013.

GSE229291 Gene expression profiling of Cav1 knock down in murine hepatic stellate cell
Contributors : Yan Zhang ; Yijie Zhang ; Tingting Chen ; Yin Ling ; Jiacheng Gong ; Jun Wang ; Jierui Li ; Qihan Xu ; Ying Meng ; Yang Li ; Xu LiSeries Type : Expression profiling by arrayOrganism : Mus musculusActivated primary murine hepatic stellate cells were transfected with siRNA targeting Caveolin-1 directly after attachment (o/n). Experiment was performed in triplicate using primary cells from 3 donor mice.
Source: GEO: Gene Expression Omnibus - April 15, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

GSE229206 RNA-sequencing analysis of Nrf2 target genes in rat pulmonary arterial smooth muscle cells and endothelial cells
Contributors : Ang Luo ; Haiyang Tang ; Yangfan JiaSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusTo investigate the genes regulated by Nrf2 in rat PASMC and PAEC, Nrf2 was knockdown by using siRNA. 48h after siRNA transfection ， cells were collected for RNA-sequencing.
Source: GEO: Gene Expression Omnibus - April 9, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research

GSE226134 Spatially defined gene signatures uncover the association of extracellular matrix genes with immunotherapy resistance in head and neck squamous cell carcinoma
Contributors : Niki Gavrielatou ; David L RimmSeries Type : OtherOrganism : Homo sapiensBackground: Immune-checkpoint inhibition (ICI) only benefits a subgroup of patients with head and neck squamous cell carcinoma (HNSCC). Several molecular and cellular components of the tumor microenvironment (TME) have been hypothesized to drive either response or resistance. Here, spatially defined whole transcriptome data were analysed in search of associations of compartment-specific gene-signatures with HNSCC immunotherapy outcomes. Methods: Pre-treatment biopsy samples from 50 immunotherapy-treated recurrent or metastatic HNSCC...
Source: GEO: Gene Expression Omnibus - April 7, 2023 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research

GSE223717 Monocyte subpopulations display disease-specific miRNA signatures depending on the subform of Spondyloarthropathy
Contributors : Ma łgorzata Stec ; Marcin Czepiel ; Mariusz Korkosz ; Maciej SiedlarSeries Type : Expression profiling by RT-PCROrganism : Homo sapiensOur data indicate for the first time that in different SpA subtypes, monocyte subpopulations bear disease-specific miRNA signatures that could be relevant for SpA diagnosis/differentiation process and may help to understand SpA etiopathology in the context of already known functions of monocyte subpopulationsThe aim of the study was to investigate the micro-RNA (miRNA) profiles in monocyte subpopulations (classical, intermediate and non-classical subpopulations) acquired fro...
Source: GEO: Gene Expression Omnibus - April 5, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by RT-PCR Homo sapiens Source Type: research

GSE223652 Hepatocyte mARC1 Promotes Fatty Liver Disease
ConclusionsCollectively, our findings from human genetics, and in vitro and in vivo hepatocyte-specific mARC1 knockdown support the potential efficacy of hepatocyte-specific targeting of mARC1 for treatment of NAFLD.
Source: GEO: Gene Expression Omnibus - April 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE227944 FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in meiotic DNA replication and recombination
Contributors : Masaru Ito ; Asako Furukohri ; Kenichiro Matsuzaki ; Yurika Fujita ; Atsushi Toyoda ; Akira ShinoharaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe formation of RAD51/DMC1 filaments on single-stranded (ss)DNAs, which is essential for homology search and strand exchange in DNA double-strand break (DSB) repair and for the protection of stalled DNA replication forks, is tightly regulated in time and space. FIGNL1 AAA+++ ATPase plays positive and negative roles in the RAD51-mediated recombination in human cells. However, the role of FIGNL1 in gametogenesi...
Source: GEO: Gene Expression Omnibus - March 31, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

GSE212883 KRT13 is upregulated in pancreatic cancer stem-like cells and associated with radioresistance
Contributors : Y Yokoyama ; D Okuzaki ; H YamamotoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic cancer is one of the most aggressive cancers and the seventh leading cause of cancer-associated death in the world. Radiation is performed as an adjuvant therapy as well as anti-cancer drugs. Because cancer stem-like cells (CSCs) are considered to be radioresistant and cause recurrence and metastasis, understanding their properties is required for the development of novel therapeutic strategies. To investigate the CSC properties of pancreatic cancer cells, we used a pancreatic ...
Source: GEO: Gene Expression Omnibus - March 29, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE146975 EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer
Contributors : Michael Rose ; Bernd Denecke ; Nadine T GaisaSeries Type : Expression profiling by arrayOrganism :Recent findings suggested a benefit of anti-EGFR therapy for basal-like muscle invasive bladder cancer (MIBC). However, impact on bladder cancer with substantial squamous differentiated (Sq-BLCA) and especially pure squamous cell carcinoma (SCC) remains unknown. Therefore, we comprehensively characterized pure and mixed Sq-BLCA (n=125) on genetic and protein expression level, and performed functional pathway and drug-response analyses with cell line models and isolated primary SCC (p-SCC) cells of the human urin...
Source: GEO: Gene Expression Omnibus - March 12, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research

GSE225459 A heterodimer of α and β hemoglobin chains functions as an innate anticancer agent
Contributors : Maharrish Chelladurai ; Dan Xu ; Sivan Izraely ; Roman Bengaiev ; Orit Sagi-Assif ; Weirong Yuan ; Metsada Pasmanik Chor ; Dave S Hoon ; Wuyuan Lu ; Isaac P WitzSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensMetastatic (as well as tumor) microenvironments contain both cancer-promoting as well as cancer restraining factors. The balance between these opposing forces determines the fate of cancer cells that disseminate to secondary organ sites. In search for microenvironmental drivers or inhibitors of metastasis, we identified, in a previous study, the beta subunit of hemoglobin (HBB) as...
Source: GEO: Gene Expression Omnibus - March 8, 2023 Category: Genetics & Stem Cells Tags: Protein profiling by protein array Homo sapiens Source Type: research

GSE204771 RNA sequencing of CTRL and siFBLN4 HAECs
Contributor : Yoshito YamashiroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFibulin-4 (Fbln4) is an extracellular protein, expressed throughout the aortic wall including endothelial cells (EC), smooth muscle cells (SMC) and fibroblasts. SMC-specific deletion of Fbln4 in mice led to formation of ascending aortic aneurysm with disruption of elastic fibers and Fbln4 is known to play role in elastic fiber formation. However, the function of Fbln4 in EC is unknown. To examine if Fbln4 deletion induces any changes in cellular phenotype of EC, we knocked down FBLN4 in human aortic endothe...
Source: GEO: Gene Expression Omnibus - March 8, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE185232 RNA-seq for siRpl14+siDux/siRpl11
Contributors : Y YI ; Y Y Zeng ; H Li ; Y LohSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBulk RNA-seq were performed on E14 cells knockdown with siRNA; siRpl14+siDux; siRpl14+siRpl11
Source: GEO: Gene Expression Omnibus - March 8, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE179124 RNA-seq for siRNA 48h
Contributors : Yao Yi ; Y Y Zeng ; H Li ; Y LohSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBulk RNA-seq were performed on E14 cells knockdown with siRNA
Source: GEO: Gene Expression Omnibus - March 8, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE167177 ATAC-seq for E14 cells knockdown with siRNA or shRNA
Contributors : Y YI ; Y Y Zeng ; H Li ; Y LohSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusATAC-seq was performed on cells E14 cells knockdown with siRNA or shRNA
Source: GEO: Gene Expression Omnibus - March 8, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

GSE225723 Effect of inhibition of Setdb1 on gene expression in AML12 cells
Contributors : Zhigang Wang ; Yi Zhang ; Yanhui LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the mRNA expression regulated by Setdb1, we established AML12 knockdown cell model by infecting Setdb1 siRNA for 72 hours
Source: GEO: Gene Expression Omnibus - March 5, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE218060 Pre-clinical evaluation of the hypomethylating agent decitabine for the treatment of T-cell acute lymphoblastic lymphoma
In conclusion, we delivered pre-clinical data of the potential of decitabine to act as a new therapeutic agent in T-LBL.
Source: GEO: Gene Expression Omnibus - March 2, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research