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Source: GEO: Gene Expression Omnibus
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Total 1028 results found since Jan 2013.
GSE231942 MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres
Contributors : Kausika K Malik ; Deepshika Pulimamidi ; Shweta TyagiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of KMT2A and KMT2F in the regulation of gene transcriptiom,siRNA based knock-down of KMT2A and KMT2F was performed in U2OS cells.
Source: GEO: Gene Expression Omnibus - May 15, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE150260 FTO regulated genes in Hepatocellular Carcinoma
Contributor : Shen YinghaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the global genes regulated by FTO high-throughput mRNA sequencing (RNA-Seq) was performed to compare the expression profile between HepG2 cells transfected with control siRNA or FTO siRNA.
Source: GEO: Gene Expression Omnibus - May 10, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE231621 Copy Number Variation data from non-trasformed human fibroblasts
Contributors : Joanna Tobiasz ; Najla Al-Harbi ; Sara Bin Judia ; Salma Majid Wakil ; Joanna Polanska ; Ghazi AlsbeihSeries Type : Genome variation profiling by genome tiling arrayOrganism : Homo sapiensThe search for biomarkers to predict radiosensitivity is important not only to individualize radiotherapy of cancer patients but also to forecast radiation exposure risks. The aim of this study was to devise a machine learning method to stratify radiosensitivity and to investigate its association with copy number variations (CNVs) as markers of sensitivity to ionizing radiation.We used the Affymetrix CytoScan HD microarrays...
Source: GEO: Gene Expression Omnibus - May 8, 2023 Category: Genetics & Stem Cells Tags: Genome variation profiling by genome tiling array Homo sapiens Source Type: research
GSE231670 Targeted suppression of siRNA biogenesis in Arabidopsis pollen
Series Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - May 7, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Expression profiling by high throughput sequencing Methylation profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE231669 Targeted suppression of siRNA biogenesis in Arabidopsis pollen RNA-seq
Contributor : Filipe BorgesSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaWe used the RNaseIII-like protein RTL1 to suppress siRNA biogenesis specifically in Arabidopsis pollen, and found distinct siRNA subsets produced in the sperm and vegetative cell lineages via the RNA polymerase IV (Pol IV).
Source: GEO: Gene Expression Omnibus - May 7, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE231668 Targeted suppression of siRNA biogenesis in Arabidopsis pollen small RNA-seq
Contributor : Filipe BorgesSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Arabidopsis thalianaWe used the RNaseIII-like protein RTL1 to suppress siRNA biogenesis specifically in Arabidopsis pollen, and found distinct siRNA subsets produced in the sperm and vegetative cell lineages via the RNA polymerase IV (Pol IV).
Source: GEO: Gene Expression Omnibus - May 7, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE231667 Targeted suppression of siRNA biogenesis in Arabidopsis pollen bisulfite-seq
Contributor : Filipe BorgesSeries Type : Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaWe used the RNaseIII-like protein RTL1 to suppress siRNA biogenesis specifically in Arabidopsis pollen, and found distinct siRNA subsets produced in the sperm and vegetative cell lineages via the RNA polymerase IV (Pol IV).
Source: GEO: Gene Expression Omnibus - May 7, 2023 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE227774 Differential gene expression profile analysis of parental, Cas9-p15 control, and MELK knockout cells
Contributor : Chandra BartholomeuszSeries Type : Expression profiling by arrayOrganism : Homo sapiensTriple-negative breast cancer (TNBC) has high relapse and metastasis rates and a high proportion of cancer stem-like cells (CSCs), which possess self-renewal and tumor initiation capacity. MELK (maternal embryonic leucine zipper kinase), a protein kinase of the Snf1/AMPK kinase family, is known to promote CSC maintenance and malignant transformation. Our study showed that MELK knockdown using siRNA or MELK inhibition using the MELK inhibitor MELK-In-17 significantly reduced invasiveness, reversed epithelial-to-mesenchymal t...
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE204969 MED12 Mutation Activates Tryptophan-Kynurenine-AHR pathway and Promotes Cell Growth in Human Uterine Leiomyoma RNA-seq
Contributors : Azna Zuberi ; Yongchao Huang ; Ariel J Dotts ; John S Coon V ; Shimeng Liu ; Takashi Lizuka ; Yang Dai ; Ping Yin ; Priyam Patel ; Serdar E BulunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUterine leiomyoma (LM) is the most common tumor in women. Estrogen and progesterone, via their receptors ER α and PR, play essential roles in LM growth. Mediator complex subunit 12 (MED12) mutations occur in 70% of all LM and are thought to drive tumor growth in a steroid hormone-dependent manner; however, the mechanisms remain unclear. Here, we performed ChIP-seq (ERα, PR, and ...
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE204968 MED12 Mutation Activates Tryptophan-Kynurenine-AHR pathway and Promotes Cell Growth in Human Uterine Leiomyoma ChIP-seq
Contributors : Azna Zuberi ; Yongchao Huang ; Ariel J Dotts ; John S Coon V ; Shimeng Liu ; Takashi Lizuka ; Yang Dai ; Ping Yin ; Priyam Patel ; Serdar E BulunSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensUterine leiomyoma (LM) is the most common tumor in women. Estrogen and progesterone, via their receptors ER α and PR, play essential roles in LM growth. Mediator complex subunit 12 (MED12) mutations occur in 70% of all LM and are thought to drive tumor growth in a steroid hormone-dependent manner; however, the mechanisms remain unclear. Here, we performed ChIP-seq (...
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE149867 AHR regulated genes in Colorectal Cancer
Contributor : Yan TingtingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the global genes regulated by AHR, high-throughput mRNA sequencing (RNA-Seq) was performed to compare the expression profile between DLD-1 cells transfected with control siRNA or AHR siRNA.
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE149783 lncSLCC1(RP11-400N13.2)-regulated genes in Colorectal Cancer
Contributor : Yan TingtingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the global genes regulated by lncRNA-SLCC1(RP11-400N13.2), high-throughput mRNA sequencing (RNA-Seq) was performed to compare the expression profile between DLD-1 cells transfected with control siRNA or lncSLCC1 siRNA.
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE222571 Haploinsufficiency of NFKBIA reshapes the epigenome and imparts disease fate in diffuse gliomas
Contributors : Markus Bredel ; Llu ís Espinosa ; Teresa Lobo-JarneSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis dataset used H3K27me3 ChIP-seq profiling of normal immortalized human astrocytes that are wild-type or have been genetically modified to by CRISPR to knockout NFKBIA or by siRNA to mimic a hemizygous NFKBIA loss
Source: GEO: Gene Expression Omnibus - April 28, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE160638 MYC induces immunotherapy and interferon- γ resistance through downregulation of JAK2
Contributors : Ettai Markovits ; Ran Elkon ; Michal J Besser ; Gal MarkelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensImmunotherapy revolutionized the treatment of advanced melanoma. As the pathways mediating resistance to immunotherapy are largely unknown, we conducted transcriptome profiling of pre-immunotherapy tumor biopsies from melanoma patients that received PD-1 blockade (n=36) or adoptive cell therapy with tumor infiltrating lymphocytes (n=37). We identified two melanoma-intrinsic mutually exclusive gene programs, which are controlled by interferon- γ and MYC, and determi...
Source: GEO: Gene Expression Omnibus - April 24, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE219162 MLX siRNA knockdown in primary human hepatocytes
Contributors : Shilpa R Nagarajan ; Eilidh J Livingstone ; Thomas Monfeuga ; Lara C Lewis ; Shahul H Liyakath Ali ; Anandhakumar Chandran ; David J Dearlove ; Matt J Neville ; Lingyan Chen ; Cyrielle Maroteau ; Maxwell Ruby ; Leanne HodsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens3' mRNA-sequencing of primary human hepatocytes treated with either non-targeting (siNT) or targeted siRNA against MLX (siMLX) (3 independent replicates with different PHH donors, n=5 prepared per donor and treatment; one siMLX sample was excluded from analysis due to low quality)
Source: GEO: Gene Expression Omnibus - April 21, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
